Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1844 for “"pathogenic"”.
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Assessing Genetic Counselors' Clinical Approach and Practices Regarding Pathogenic/Likely Pathogenic Variant Downgrades
<p>Although rare, variant downgrades from a pathogenic/likely pathogenic (P/LP) variant to a variant of uncertain significance can have a significant impact on patients and their families in the clinical cancer setting. However, there is a lack of literature about how to approach these potentially …
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Antimalarials from Plant Pathogenic Fungi
… antimalarial compounds from necrotropic plant pathogenic fungi. Various phytotoxins released by necrotropic plant pathogenic fungi may inhibit the plant-like metabolic pathways in the apicoplast, a chloroplast-like organelle, essential for the survival of apicomplexan parasites, such as …
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Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
Pathogenic HIV/SIV infection induces high viral loads, aberrant immune activation, and dysfunction in numerous immunologic cells (including gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via …
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How did Listeria monocytogenes become pathogenic?
… of ascertaining insights into the evolution of pathogenic capability of its members. The phylogeny of Listeriae had not yet been clearly resolved due to a scarcity of phylogenetically informative characters within the 16S and 23S rRNA molecules. The genus Listeria contains six species: L. …
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Investigating Pathogenic Mechanisms and Biomarkers in Alzheimer’s Disease
… in patients. This thesis aims to investigate pathogenic mechanisms associated with AD, including inflammation, metabolic dysfunction, and impaired hormonal signalling, and to propose a novel approach to measure in vivo biomarkers in blood samples from neurodegenerative disease patients. More …
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PATHOGENIC MECHANISMS OF TRUNCATED TITIN IN DILATED CARDIOMYOPATHY
Truncating variations in the gene encoding the essential sarcomeric protein titin (TTNtv) have long been known to cause dilated cardiomyopathy (DCM) and, recently, peripartum cardiomyopathy (PPCM). How these genetic variations lead to the hypocontractility that is characteristic of DCM and PPCM has …
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Molecular Study of the B19 (Human) Pathogenic Parvovirus
<p>The B19 (human) parvovirus is a small single stranded DNA virus of 5.4 kilobases. B19 is specific for erythroid progenitor cells and has been propagated in vitro only with human erythroid bone marrow. Replication of viral DNA and the viral protein products of B19 appear similar to those of other …
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Rheumatoid arthritis and atherosclerosis: common pathogenic mechanisms explored
… Together this body of work identifies shared pathogenic mechanisms between RA and atherosclerosis and identifies potential therapeutic targets for both RA and atherosclerosis.
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Innate immunomodulatory strategies and pathogenic basis for nidoviruses
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Proteolethargy is a pathogenic mechanism in chronic disease
The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent syndromes associated with pathogenic signaling, such as diabetes and chronic inflammation, where our understanding is more limited. Here, I present evidence that pathogenic signaling …
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NOVEL PERSPECTIVES IN THE CONTROL OF PLANT PATHOGENIC OOMYCETES
Plant pathogenic oomycetes pose significant threats to the productivity, quality and sustainability of agricultural production. Traditionally, the control of oomycete-borne diseases is achieved by means of chemical control based on fungicides. However, the negative impact of these molecules on the …
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Consequences of Pathogenic Mitochondrial DNA Mutations in Cancer Progression
… cancer cell lines with defined pathogenic mutations, and secondly, by the establishment of a collection of patient tumor xenograft models with varied mtDNA status. Chapter two details the development of a new cytoplasmic hybrid (cybrid) generation method that simplifies the …
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Virulence and pathogenic mechanisms of <i>Legionella pneumophila</i>
… in an attempt to identify potential virulence or pathogenic factors. <br></br><br></br>Virulent forms multiplied within guinea pig alveolar macrophages maintained in tissue culture over 48 hours and phagosome lysosome fusion was not inhibited in these macrophages. Avirulent strains did not …
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Pathogenic Characterization and Therapeutic Development for Fiblrolamellar Hepatocellular Carcinoma
<p>Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer that primarily affects adolescents and young adults. There are no known successful systemic chemotherapies for this disease, and thus, surgery is the only potential path to a cure in patients with FLC. Once the disease has grown …
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Susceptibility Testing of Pathogenic Fungi With a Radiometric System
A radiomethric method was used to determine the susceptibility of clinical isolates of dimorphic fungi (Histoplasma capsulatum, Blastomyces dermatitidis, Sporothrix schenckii) to selected antifungal agents. Antifungal agents evaluated were Amphotericin B, 5-fluorocytosine, Nystatin, Ketoconazole, …
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