Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"pathogen-associated molecular patterns (PAMPs)"”.
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Regulation of receptor kinase-mediated immune signalling by dynamic phosphorylation
Plants recognize pathogen-associated molecular patterns (PAMPs) via cell surface-localized pattern recognition receptors (PRRs), initiating a broad-spectrum defense response against pathogens, known as PRR-triggered immunity (PTI). However, immunity comes at a cost; and immune responses need to be …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… of RIG-I and MDA5 both in vitro and in vivo in pathogen recognition and control of WNV. Lack of RIG-I or MDA5 alone results in decreased innate immune signaling and virus control in primary cells in vitro and increased mortality in mice. We also generated RIG-I -/- x MDA5 -/- double knockout …
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Periodontal bacterial-DNA initiated immuno-inflammatory responses in human osteoblastic cells
… anaerobic bacteria. These bacteria possess pathogen-associated molecular patterns (PAMPs) that interact with various receptors including Toll like receptors (TLRs). Bacterial DNA (bDNA) is one of the PAMPs mainly recognized by TLR9. Interaction of bDNA and its receptors leads to activation …
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
… are recognized by the innate immune system via pathogen-associated molecular patterns (PAMPs) activating Toll-like receptors (TLRs) on host cells. I investigated the role that PAMPs play in Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS. Both genetic and environmental …
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Investigating the regulation of plant immunity by the N-degron pathway
… al., 2016; Vicente et al., 2018), although the molecular mechanisms underpinning this activity are not fully understood. My project aims to elucidate the contribution of specific N-degron pathway enzymatic components to immunity through complementary approaches in Arabidopsis thaliana. These …
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Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis
… cancerous cells. On the other hand, tumor-associated immune cells can contribute to tumor progression by secreting growth factors as well as immunosuppressive, pro-angiogenic and/or pro-metastatic mediators. In this thesis we identified a factor (Wnt5a) that may be involved in skewing …
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Investigation of the molecular basis of PAMP-induced resistance
… of conserved microbial features termed pathogen-associated molecular patterns (PAMPs) by surface-localized pattern-recognition receptors (PRRs) constitutes the first layer of plant innate immunity. Although details of early immune signaling events are starting to be unveiled, the …
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Mapping PAMP Responses and Disease Resistance in Brassicas
… defence in plants is based on the perception of pathogen-associated molecular patterns (PAMPs) leading to PAMP-triggered immunity (PTI). PTI is increasingly being investigated in crop plants, where it may have potential to provide durable disease resistance in the field. Limiting this work, …
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Controlled release microneedle technologies for the enhanced immunogenicity of subunit vaccines
… typically consist of a protein antigen and a molecular adjuvant, has recently been improved by completing multiple injections of the vaccine with an exponential dosing profile over time. The hypothesis is that as viruses replicate in a host organism, they shed exponentially increasing …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
The innate immune system recognizes pathogens via unique signals present in the invading organism upon infection known as pathogen-associated molecular patterns (PAMPs). Recognition of PAMPs during viral infection requires host molecules capable of interpreting these foreign signals called pattern …
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Characterisation of potential regulators of PAMP-triggered immunity
… of plant innate immunity is the perception of pathogen-associated molecular patterns (PAMPs) through surface-localised pattern-recognition receptors (PRRs). EFR and FLS2 are well characterised PRRs, which recognise the bacterial elongation factor Tu and flagellin, respectively. A variety of …
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Molecular basis of plant cell death suppression by the phytophthora infestans effector AVR3a
Plants actively perceive pathogens and activate their immune system upon pathogen recognition. The first encounter with the pathogen relies on the recognition of highly conserved microbial molecules known as pathogen-associated molecular patterns (PAMPs) by cell surface receptors called …
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Visualisation of innate immune signalling complexes in cells by cryo-electron tomography
… of NLRP3, a sensor protein to various danger-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), induces oligomerisation of adaptor protein ASC into large puncta. Caspase-1 is recruited and then cleaved to initiate caspase-1 dependent pyroptosis and the …
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Expression of inflammasome-related molecules from U87MG cells cocultured with Naegleria fowleri in the non-contact system
… soil, water and sediment, exist as a virulent pathogen causing fetal primary amoebic meningoencephalitis (PAM) in experimental animals and in humam. Inflammasomes are large intracellular multiprotein complexes that play a central role in innate immunity. They detect and respond to a large range …
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Sensing Foreign DNA: The Role of DNA-PKcs in Human Anti-viral Innate Immunity
… (PRRs) are a first line of defence against pathogens and function to generate a productive innate immune response. PRRs sense pathogen-associated molecular patterns (PAMPs), such as viral genomic DNA, which is a major PAMP during DNA virus infection. Viral DNA sensing leads to the activation …
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Mechanisms of phage detection by bacterial innate immune proteins
… detect foreign invaders through conserved pathogen-associated molecular patterns (PAMPs). In addition to the MCPs, I found that CapRel_SJ46 can directly bind to another unrelated and structurally different phage protein, called Gp54. Bas11 phages harbor two trigger proteins, and both are …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… antiviral signaling upon recognizing distinct pathogen associated molecular patterns (PAMPs). TLR3, RIG-I and MDA5, trigger complex intertwined signaling pathways in response to viral dsRNA leading to the activation of interferon regulatory transcription factors IRF3, IRF7 and NF-κB. These …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
Recognition of conserved pathogen-associated molecular patterns (PAMPs) by host pattern recognition receptors (PRRs) results in the activation of innate signaling pathways that drive the innate immune response and ultimately shape the adaptive immune response. RepliVAX WN, a single-cycle flavivirus …
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Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns
… (PRRs) on host cells recognize motifs known as pathogen associated molecular patterns (PAMPs) that are common to groups of microbes. Examples include LPS on Gram-negative bacteria, the structural motif PGN common to all bacteria, MDP the smallest immunostimulatory unit of PGN, and poly I:C the …
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Battling Bacteria: Characterizing the NOD-Like Receptor (NLR) Immune Response to <i>Brucella abortus</i> and <i>Borrelia burgdorferi</i> in Host-pathogen Interactions
… Receptors (PRRs), which sense conserved molecular motifs known as Pathogen-Associated Molecular Patterns (PAMPs), the innate immune system sets a system of checks and balances to regulate inflammation in host defense. In this dissertation, we focus on one class of PRRs known as the …
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