Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"pathogen-associated molecular patterns"”.
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Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns
… (PRRs) on host cells recognize motifs known as pathogen associated molecular patterns (PAMPs) that are common to groups of microbes. Examples include LPS on Gram-negative bacteria, the structural motif PGN common to all bacteria, MDP the smallest immunostimulatory unit of PGN, and poly I:C the …
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Analysis Of Yscf And Associated Homologs And The Presence Of An Inflammatory Molecular Pattern
<p>Gram-negative pathogen, Yersinia pestis, expresses a type three secretion system to accomplish its virulence. The YscF needle protein provides a conduit of effectors from bacterium to eukaryote and is exposed to the host immune system. This thesis explores YscF and its associated needle homologs …
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Urinary Excretion of (1-3)-Beta-D-Glucans.
… wall of various fungi and bacteria; they are pathogen associated molecular patterns that circulate during infection and modulate immunity. Our laboratory has previously established the pharmacokinetics of intravenously and orally administered glucans; the present studies investigated the renal …
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Regulation of receptor kinase-mediated immune signalling by dynamic phosphorylation
Plants recognize pathogen-associated molecular patterns (PAMPs) via cell surface-localized pattern recognition receptors (PRRs), initiating a broad-spectrum defense response against pathogens, known as PRR-triggered immunity (PTI). However, immunity comes at a cost; and immune responses need to be …
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Quantitative analysis of TLR-4-mediated cell responses in murine macrophages
… bacterial infection. By recognition of specific pathogen-associated molecular patterns such as lipopolysaccharide (LPS), TLR-4 can in tandem initiate a pair of downstream signaling pathways to regulate cytokine/chemokine release, endotoxin tolerance and apoptosis, which have been suggested to …
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The role of PLK1 in NLRP3 inflammasome activation
… in response to a variety of DAMPs (Damage-Associated Molecular Patterns) and PAMPs (Pathogen-Associated Molecular Patterns). Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokines (IL-1 and IL-18) release and pyroptosis, an inflammasome-specific form of cell death. The …
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Regulating Inflammation Through Exercise-Mediated Trained Immunity or Genetic Manipulation of the Interferon Locus
… functions, in virus infection and PAMPs (pathogen-associated molecular patterns) mediated inflammatory responses. To study this, we generated unique knockout (KO) mice of type I interferons (IFN-Is) locus and evaluated viral clearance and other parameters such as cytokine, interferon …
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Mapping the immunological receptors CD14 and macrophage receptor with collagenous structure (MARCO) and their innate recognition potential on trophoblast cells: relevance for human pregnancy
… and surveillance through the immune system. Pathogens are detected through pattern recognition receptors, which have a key role in the innate recognition by transducing signals from pathogen-associated molecular patterns. Lipopolysaccharide, a PAMP of Gram-negative bacterium, is recognized by …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… of RIG-I and MDA5 both in vitro and in vivo in pathogen recognition and control of WNV. Lack of RIG-I or MDA5 alone results in decreased innate immune signaling and virus control in primary cells in vitro and increased mortality in mice. We also generated RIG-I -/- x MDA5 -/- double knockout …
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Periodontal bacterial-DNA initiated immuno-inflammatory responses in human osteoblastic cells
… anaerobic bacteria. These bacteria possess pathogen-associated molecular patterns (PAMPs) that interact with various receptors including Toll like receptors (TLRs). Bacterial DNA (bDNA) is one of the PAMPs mainly recognized by TLR9. Interaction of bDNA and its receptors leads to activation …
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
… are recognized by the innate immune system via pathogen-associated molecular patterns (PAMPs) activating Toll-like receptors (TLRs) on host cells. I investigated the role that PAMPs play in Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS. Both genetic and environmental …
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Investigating the regulation of plant immunity by the N-degron pathway
… al., 2016; Vicente et al., 2018), although the molecular mechanisms underpinning this activity are not fully understood. My project aims to elucidate the contribution of specific N-degron pathway enzymatic components to immunity through complementary approaches in Arabidopsis thaliana. These …
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Analysis of the role of Pellino2 in the Activation of the NLRP3 Inflammasome.
… is the first line of defence against invading pathogens and is responsible for both initial pathogen recognition and mounting an effective immunological response. The recognition of conserved pathogen-associated molecular patterns can be carried out by a number of families of innate immune …
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Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis
… cancerous cells. On the other hand, tumor-associated immune cells can contribute to tumor progression by secreting growth factors as well as immunosuppressive, pro-angiogenic and/or pro-metastatic mediators. In this thesis we identified a factor (Wnt5a) that may be involved in skewing …
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Investigation of the molecular basis of PAMP-induced resistance
… of conserved microbial features termed pathogen-associated molecular patterns (PAMPs) by surface-localized pattern-recognition receptors (PRRs) constitutes the first layer of plant innate immunity. Although details of early immune signaling events are starting to be unveiled, the …
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Mapping PAMP Responses and Disease Resistance in Brassicas
… defence in plants is based on the perception of pathogen-associated molecular patterns (PAMPs) leading to PAMP-triggered immunity (PTI). PTI is increasingly being investigated in crop plants, where it may have potential to provide durable disease resistance in the field. Limiting this work, …
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Controlled release microneedle technologies for the enhanced immunogenicity of subunit vaccines
… typically consist of a protein antigen and a molecular adjuvant, has recently been improved by completing multiple injections of the vaccine with an exponential dosing profile over time. The hypothesis is that as viruses replicate in a host organism, they shed exponentially increasing …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
The innate immune system recognizes pathogens via unique signals present in the invading organism upon infection known as pathogen-associated molecular patterns (PAMPs). Recognition of PAMPs during viral infection requires host molecules capable of interpreting these foreign signals called pattern …
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Characterisation of potential regulators of PAMP-triggered immunity
… of plant innate immunity is the perception of pathogen-associated molecular patterns (PAMPs) through surface-localised pattern-recognition receptors (PRRs). EFR and FLS2 are well characterised PRRs, which recognise the bacterial elongation factor Tu and flagellin, respectively. A variety of …
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Molecular basis of plant cell death suppression by the phytophthora infestans effector AVR3a
Plants actively perceive pathogens and activate their immune system upon pathogen recognition. The first encounter with the pathogen relies on the recognition of highly conserved microbial molecules known as pathogen-associated molecular patterns (PAMPs) by cell surface receptors called …
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