Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"pathogen virulence"”.
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Exploiting crosstalk between growth and immunity in plants : the role of the <i>Phytophthora infestans</i> effector AVR2 in potato late blight
… biggest challenges being the control of plant pathogens to ensure a healthy crop.<br/><br/>The interaction between plant and pathogen is complex, with subtleties at the molecular level dictating the boundary between health and disease. This is exemplified by pathogen effectors; secreted …
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Arousal patterns, fungal loads, and wing damage in a surviving population of little brown bats (Myotis lucifugus)
… of environment (temperature and moisture), pathogen virulence, and host susceptibility on survival. Host response was assessed using temperature-sensitive radio transmitters (<em>n</em> = 37) and ultraviolet photography (<em>n</em> = 57), while fungal load (<em>n</em> = 56) was evaluated …
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Control of Salmonella Virulence by Microbiota-Derived and Dietary Fatty Acids
… host immunity to defend against invading pathogens, how microbiota directly antagonizes pathogen virulence is less studied. In particular, gut microbiota produces large amounts and varieties of small molecules that may impact both host immunity and pathogen virulence. In this thesis, I …
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Evolutionary Trade-offs Between Antimicrobial Resistance and Virulence in Pseudomonas aeruginosa
… efficacy, yet its evolutionary consequences for pathogen virulence and growth remain poorly resolved. This thesis addresses this gap using Pseudomonas aeruginosa, a multidrug-resistant pathogen capable of both acute toxin-mediated and chronic colonization-based infections. From independently …
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Nutrition modulates the interaction between the bacterium Xenorhadbus nematophila and its lepidopteran host Spodoptera littoralis
… the characteristics of communities. Host-pathogen relationships are unique in ecological communities since hosts can also be considered as an ecosystem in which commensal microorganisms, parasites and host tissues compete for resources. At all ecosystem levels, resource availability …
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Chemical Reporters for Bacterial Pathogenesis and Beyond
… and dynamic interplay of host defense and pathogen virulence pathways that requires new methods for mechanistic investigation. Towards this goal, I have developed chemical reporters of nucleic acid and protein synthesis and posttranslational modifications to explore their functions in …
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Creation of Bioinformatics Approaches to Understand Host-Pathogen Molecular Mimicry
… some it is the key to survival. Across phyla, pathogens imitating aspects of their host is crucial to their continued survival and proliferation. Also called molecular mimicry, imitation of host biomolecules has been observed to target a wide range of processes, including host signaling …
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Host-pathogen interactions in the innate immune response of the nematode Caenorhabditis elegans
… to investigate the biology of a number of human pathogens. This work continues to uncover mechanisms of host immunity and pathogen virulence that are either analogous to those involved during pathogenesis in alternative animal hosts or mechanisms which are, thus far, unique to the worm. In this …
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Jautienoje aptiktų Šiga toksiną išskiriančių Escherichia coli identifikavimas ir genominė analizė /
… coli (STEC) is one of the most common foodborne pathogens, characterized by the synthesis of Stx1 and/or Stx2 toxins. STEC is associated with numerous human diseases worldwide, ranging from mild diarrhea to hemorrhagic colitis (HC), hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic …
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Characterizing the Innate Immunity in the Hawaiian Coral Montipora capitata
… North and South Bay were exposed to a bacterial pathogen associated with MWS in a laboratory challenge experiment. Overall, constitutive immune activity varied, with corals from the North Bay exhibiting higher levels than the South Bay. In the infection experiments, several orange colonies …
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Understanding the Evolution of Emerging Bacterial Pathogens in Response to Host Resistance
… of emerging infectious diseases. Microbial pathogenesis and virulence are remarkably complex traits, and only by considering them in the context of their hosts can we begin to unravel key questions as to how and why disease emerges and persists. The period immediately following a host-shift …
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Exposure heterogeneity, host immunity and virulence evolution in a wild bird-bacterium system
… creating a diverse and challenging landscape for pathogens to replicate and transmit. This dissertation work sought to determine sources of immunological heterogeneity, as well as the consequences of this heterogeneity on pathogen fitness and evolution. A major source of heterogeneity in …
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Understanding the Impact of Plant Nutrition on Plant-Oomycete Interactions
… by various threats from the environment such as pathogens, abiotic stresses, and animal attacks. Nutrient content and distribution are essential for plant growth and development as well as plant immunity. Pathogens extract nutrients from host plants to benefit their own growth and reproduction. …
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Characterisation of the G. mellonella cellular innate immune response and a comparison with the human neutrophil
… model organisms in areas of research such as pathogen virulence studies, the development of novel therapeutics and the screening of microorganism strains are increasing. Some of the reasons for this are the lower cost of insects, results are often acquired very quickly with insect experiments …
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Host-pathogen interactions and conservation implications of snake fungal disease over broad geographical scales
… complete species extinction. Among emerging pathogens, pathogenic fungi have been responsible for drastic declines in several high-profile vertebrate taxa, such as Batrachochytrium dendrobatidis causing chytridiomycosis in many species of amphibians worldwide. Recently, an emerging infectious …
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Characterization of Pyrenophora Tritici-Repentis in Wheat and Rye to Study Tan Spot Susceptibility and Insights Into Its Relationship with Stem Rust Resistance
… tan spot susceptibility in 1970’s, to know the pathogen virulence profile, and explore the sources of tan spot resistance, we recovered isolates from wheat and rye and evaluated wheat and rye lines with different Ptr isolates. To determine the reaction of 247 prestem rust-epidemic wheat …
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Applying effectoromics and genomics to identify resistance against <i>Rhynchosporium commune</i> in barley
… is one of the most destructive fungal pathogens of barley worldwide. It causes scald, responsible for reduced grain quality and yield losses of up to 40%. This project aimed to identify genetic resistance in barley using two different approaches: an effector approach through the …
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Shifting disease dynamics following the invasion of an emerging wildlife pathogen
The introduction of pathogens to new regions can have significant impacts to human, agricultural and wildlife health. Introduced pathogens can change and adapt to new hosts (i.e. the species that they infect) and to new habitats. These factors can ultimately influence their impact on host …
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Genetic characterization of Rpp1-mediated Asian soybean rust resistance using in-depth transcriptomic and genomic analyses
… RNA loci that are involved in increasing either pathogen virulence or host resistance. To possibly identify and clone the Rpp1 allele(s) in PI 594760B and PI 561356, and to uncover the mechanism of the dominant susceptible phenotype, fosmid libraries were constructed, screened and sequenced, and …