Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"pathogen resistance"”.
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Characterization of Bacterial Metabolites Involved in Host Pathogen Resistance
<p>The intestinal microbiome can mediate host resistance to enteric pathogens by modulating host immunity or by directly inhibiting pathogen growth and virulence. Although the abundance and diversity of bacterial metabolites in the intestine is appreciated, the majority of intestinal bacteria and …
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Genetic analysis of innate immunity in Caenorhabditis elegans
Pathogen resistance in Caenorhabditis elegans is a model for studying innate immunity. Several conserved activators in the p38 PMK-1 pathway have been identified and are required for pathogen resistance to the bacterium Pseudomonas aeroginosa. Thus far, screens have been performed to identify …
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Heme Peroxidase Hpx-2 Protects Caenorhabditis Elegans From Pathogens
… and the dual oxidase, BLI-3, contribute to resistance against the human pathogen<em> Enterococcus faecalis,</em> likely functioning in conjunction with each other. However, the exact mechanism(s) by which peroxidases and NOX/DUOXs contribute to pathogen resistance remain unclear. Here, we …
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Methods to enable the detection of targeted AmphDI glycosyltransferase mutants that transfer GDP-C2’epimycosamine to amphoteronolide
… have important limitations, and the emergence of pathogen resistance is further weakening the clinical efficacy of most of these medicines. Amphotericin B (AmB) remains the last line of defense in treating these infections. Remarkably, this potent and broad-spectrum fungicidal agent has evaded …
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Immune Priming in A. Mellifera
… experience to progeny, producing offspring pathogen resistance and ultimately survival from infections. In colony-forming insects like the honey bee Apis mellifera, TgIP would yield a form of lasting immunity benefiting subsequent generations. TgIP has been demonstrated in multiple social …
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Improving barley for biofuel production – efficient transformation for lignin manipulation
… lignin plays a major role in culm strength and pathogen resistance, the influence of down-regulation of CAD on these features was characterised. The changed physicochemical nature of cell walls in HvCAD2 RNAi lines does not decrease the strength of the straw and does not decrease the resistance …
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Synthesis of Novel Agrochemicals as Potential Plant Immunization Agents.
… for the "immunization" of plants against several pathogens. These compounds induce systemic acquired resistance (SAR) in plants, leading to broad-based, long-lasting resistance to a wide range of pathogens. The salicylic acid binding protein 2 (SABP 2) has been identified as a key enzyme in the …
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Systems View Of The Soybean Genetic Mechanisms Involved In The Response To Plant Pathogen Infection
… geneticists working towards improving traits for pathogen resistance.Results reported here provide a systemic view at both the genetic and biochemical level, and were generated by data-mining gene expression data from soybean cultivars inoculated with plant pathogens and also recombinant inbred …
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Evolutionary and functional study of plant cell wall polysaccharide glucomannan
… factor MYB15 (myeloblastosis family 15) enhances pathogen resistance in *csld5*. These results not only demonstrate the diversity of mannan-modifying enzymes, but also highlight the importance of their physiological roles, which plants have acquired throughout their evolutionary history. …
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Improving Disease Resistance for Shrimp Through Application of Probiotics in Feed
… in shrimp emerged. Shrimp losses attributed to pathogens can be greatly reduced through probiotic use, which are known to act as natural immune enhancers and promote pathogen resistance. However, research on probiotic treatment against EMS disease is lacking. The overall project goal was to …
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Maize β-glucosidase substrate specificity and natural substrates
… DIMBOA levels are associated with increasing resistance to several pests. The highest levels of enzyme activity and hydroxamic acids along K55 and H95 shoot length were found near the node. Tissue distribution of hydroxamic acids and β-glucosidase activity was also determined. In K55, both …
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Computational insights into the ecology of the human microbiota
… the development of the immune system and pathogen resistance, while imbalances among them have been associated with several diseases. In this work, I develop computational methods to gain key insights into the ecological principles that shape these communities. In the first chapter, I …
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Functional analysis of soybean PR-10 genes
… Understanding how soybean responds in defense to pathogens at a molecular level would help produce innovated seeds and plants that can better withstand biological attacks. This research was designed to characterize a soybean gene family that responds to multiple pathogens within a few hours of …
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Transposable Elements and the Evolution of Virus Resistance in Drosophila melanogaster
… shown that there is large genetic variation in pathogen resistance, and that a significant amount of genetic variation to virus resistance can be explained by major-effect polymorphisms in a small number of genes. In this thesis I will explore the role of transposable elements in the evolution …
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A synthesis enabled understanding of Amphotericin B leading to derivatives with improved therapeutic indices
… To lower the impact of invasive fungal pathogens on the global population, more progress must be made in the areas of diagnostic tests and safe and effective new therapies. Although Amphotericin B (AmB) has served as the last line of defense against invasive fungal infections without …
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Mechanisms Of Presynaptic CaV2 Calcium Channel Localization In Caenorhabditis Elegans
… pqn-53 mutants are resistant to killing by pathogenic bacteria, potentially due to constitutive activation of the non-canonical unfolded protein response. pqn-53 couples multipass transmembrane protein biogenesis with endoplasmic reticulum stress, and provides insights into the regulation of …
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Engineering resistance to maize lethal necrosis
… aid the evolution and spread of novel plant pathogens. Limited genetic diversity in commercial crop lines can result in widespread susceptibility to emerging pathogens. Pathogen resistance may be developed through conventional breeding approaches, or a number of transgenic strategies. This …
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Investigating physiological collaborations between a lower termite and its symbionts
… the role of symbionts in protection against pathogens, and 3) identifying gene products that bacterial symbionts contribute to naïve and pathogen-challenged termites. Bioassays coupled with in vitro enzyme assays, gene expression analysis, and symbiont population estimations show that …
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Examining perceived pathogen threat and body weight preferences using experimental priming
… such as disease and the potential existence of pathogens. Furthermore, research has indicated that individuals have a behavioural immune system that causes them to become more vigilant in pathogen heavy environments and implicitly change their behaviour accordingly. However, no research has …
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The development of a transparent soil and its application in imaging root trajectories and root bacteria interactions
… and can act as a biocontrol agent by conveying pathogen resistance to the plant. For this reason, the interaction between lettuce roots and GFP labelled P. fluorescens was studied with the aim of quantifying colonisation patterns along the root and the abundance of bacteria in the substrate …
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