Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"pathogen exposure"”.
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Deciphering Features of Protective or Maladaptive Cellular Immunity in the Airways Following Primary and Repeated Pathogen Exposure
… Infection with viral, microbial, and eukaryotic pathogens can disrupt airway homeostasis, leading to local and systemic inflammation, which can either contribute to the clearance or persistence of the pathogen. Prior antigenic exposure - prophylactically or from a previous infection - can promote …
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Fumarate Inhibits TNF-α Release
… utilize two forms of immunity to combat pathogens. Innate immunity is considered the first line of defense that utilizes immediate action and three barriers. Innate immunity responses typically occur within minutes of pathogen exposure resulting in cellular receptor activation and acute …
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Painting the Past: Uncovering Ancestral Contributions to Complex Human Phenotypes in Western Eurasia
… to higher frequency, likely in response to novel pathogen exposure resulting from lifestyles changes and leading to a heterogeneous risk profile across Europe today. These results demonstrate the power of combining large ancient and modern DNA panels, using local ancestry assignment methods, to …
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The Challenges and Opportunities in Monitoring and Modeling Waterborne Pathogens in Water- and Resource-Restricted Africa: Highlighting the critical need for multidisciplinary research and tool advancement
… across the landscape and can facilitate shared exposure to a community of waterborne pathogens. Despite remarkable global progress in sanitation and hygiene development in the past two decades, infectious diarrhea remains a prominent public health threat in sub-Saharan Africa. This thesis …
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Polycyclic Aromatic Hydrocarbons and the Microbiomes of Two Benthic Species
… This study set out to examine the effects of oil exposure on the microbiome of two benthic species, southern flounder (Paralichthys lethostigma) and eastern oysters (Crassostrea virginica) to further understand the effects of both short- and long-term oil contamination. The bacterial component of …
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Bacteria Prediction For Recreational Waters Through The Use Of Artificial Neural Networks
… Bacteria (FIB) to determine the risk of exposure to pathogens in water. If there is a presence of these indicator bacteria, pathogenic microorganisms may also be present. These bacteria in recreational water bodies pose a health threat to people if ingested during activities such as …
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The Structure and Function of Amphibian Skin Bacterial Communities and Their Role in Susceptibility to a Fungal Pathogen
… manipulation of the skin microbiota and pathogen exposure. Results of this study demonstrated that Bd is a selective force on cutaneous bacterial community structure and function, and suggest that beneficial states of bacterial structure and function may serve to limit infection and …
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Antibody-Mediated Modulation of Polyclonal Immune Responses
<p>Upon pathogen exposure, two main lines of defense are sequentially activated: the innate immune response and the adaptive immune response. The innate immune response is the first line of defense, and consists mainly of myeloid cells that are quickly activated within hours to days to engage in a …
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Effects of inulin or yeast cell wall extract on nutrient digestibility and fecal fermentative end-product concentrations of healthy adult dogs fed raw diets
… Raw meat-based diets have been shown to increase pathogen exposure, contain nutritional imbalances if not carefully formulated and monitored, and may be inconvenient for the pet owner to store or feed. Despite the proposed advantages and risks of feeding raw diets, little research has been …
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Elucidating fecal contamination exposure in low-income countries, the contribution from child feces disposal practices and soil ingestion, and links to child health
Enteric pathogens transmitted via fecal-oral pathways cause enteric infections that have substantial health and human capital consequences, making it critical to reduce child exposure to fecal contamination. Current water, sanitation, and hygiene programs in low-income countries often focus on …
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Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic
… antibiotic resistance even after prolonged pathogen exposure. This resistance evasion is attributed to a dual polyprenyl phosphate binding mechanism. In this thesis, I present discovery and optimization efforts to expand this promising novel class of antibiotic natural products as well as to …
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Losing Connection: Developmental Stress and Synaptic Loss in Caenorhabditis elegans
… that stress from either genetic, proteotoxic, pathogenic, or chemical exposure results in the generation of fewer net synapses. We observed a synergistic developmental loss in animals experiencing combined stress from proteotoxic and pathogenic stress. Together, these results suggest multiple …
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Understanding Osmoregulation and Immunity in Heteromyid Rodents Through Insights Gained from RNA-Seq
… pressure on immune response from increased pathogen diversity and burden in the tropics would fashion sequence evolution and different levels of gene regulation for immunity genes in <em>H. desmarestianus</em>. As in chapter 2, I generated a large amount of sequence data while winnowing down …
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Effect of Oil and Natural Gas Development on Survival and Health of White-tailed Deer in the Western Dakotas
… protein values among study areas during 2014. Pathogens with the highest antibody prevalence included West Nile Virus (85%), epizootic hemorrhagic disease (48%), and malignant catarrhal fever (32%). We speculate that low sodium values and West Nile Virus may be contributing to low neonate …