Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"pathogen detection"”.
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High sensitivity pathogen detection assays from crude samples
Detection of pathogens for diagnosis of disease is very important for advancing healthcare, especially in resource-scarce settings with minimal access to laboratory equipment or techniques. Culture being the gold standard for bacterial and fungal detection and immunoassay or nucleic acid-based …
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Label-free sensor for selective pathogen detection using carbon nanoparticles
… platform for rapid and reliable bacterial detection. However, critical requirements i.e. limit of detection (LOD), fast time of response (TOR), ultra-sensitivity with high reproducibility and ability to distinguish between bacterial strains have yet to be met within a single sensing …
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Differential Interactions of Lipopolysaccharides with Lipid Bilayers: Applications for Pathogen Detection
… of new tailored methods for the discriminative detection of amphiphilic lipopolysaccharide (LPS) antigens, so as to improve screening methodologies for food-safety applications, and detection of amphiphiles in general. LPS is associated with the outer membrane of Gram-negative bacteria, and is a …
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Digital amplification for pathogen detection in bloodstream infections from whole blood
Sensitive and specific detection of bacteria is essential for control and treatment of bloodstream infections. Sepsis, a diagnostic challenge of blood stream infections, causes thousands of deaths each year. The gold standard for detection and identification of microorganisms is blood culture, …
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Development of low-cost and easy-to-use tools for multiplex pathogen detection
Thesis (Ph. D.)--Michigan State University. Environmental Engineering, 2010
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CRISPR-integrated Biosensors for Human Health: Novel strategies for pathogen detection and cancer screening
Rapid and accurate detection of pathogens and genetic mutations is essential for improving public health, guiding clinical decisions, and ensuring food safety. CRISPR-based biosensors offer a promising solution due to their programmability, sensitivity, and versatility. This dissertation focuses on …
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Use of Bioinformatics to Investigate Abiotic Stress in Arabidopsis and to Design Primers for Pathogen Detection
… and in-silico testing of primers for PCR-based pathogen detection will be discussed. Phospholipase D (PLD) has been implicated in a variety of stresses including osmotic stress and wounding. PLDα 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and promotes abscisic acid signaling. …
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Surface Directed Monoclonal Antibodies against STEC Aid in the Reduction of Pathogen Detection Times from Food and Water
… at the Canadian Food Inspection Agency for the detection of Shiga toxin producing E. coli (STEC) are time consuming and tedious, taking up to 5 days before a positive sample can be confirmed. The goal of this project was to streamline the detection procedure for serogroup O157 and 6 important …
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Aster Yellows Phytoplasma, Aster Leafhopper And Canola: Development And Application Of Improved Molecular Methods For Pathogen Detection And Genetic Characterization Provide Increased Understanding Of Aster Yellows Disease
… insect-vectored, difficult-to-culture bacterial pathogens that infect a wide variety of plants. They are associated with diseases connected with severe yield losses in global agricultural production, including Aster Yellows (AY). Aster Yellows phytoplasma (AYp) is primarily transmitted by the …
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Utilization of ferrioxamine microarrays for the rapid detection of pathogenic bacteria
… factors, due to their prominent role in pathogenicity. The work presented here focuses on ferrioxamine (FOx) as an “immutable” ligand for pathogen detection. A number of bacterial strains expressing high-affinity FOx receptors were identified by a proteomic BLAST search, and screened …
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AI-assisted Development of Energy Harvesters for POCT
… neural network optimization to enhance design of pathogen detection and energy harvesting in biomedical applications. The work is centered on the design and validation of impedance spectroscopy-based biosensors that offer sensitive, and specific pathogen detection, crucial for timely healthcare …
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Surface Enhanced Raman Spectroscopy as a Tool for Waterborne Pathogen Testing
The development of a waterborne pathogen detection method that is rapid, multiplex, sensitive, and specific, would be of great assistance for water treatment facilities and would help protect water consumers from harmful pathogens. Here we have utilized surface enhanced Raman spectroscopy (SERS) in …
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Empowering vision machine perception for robust telehealth applications
… validated for clinical relevance and abnormality detection and documentation. Additionally, the smartphone-based viral pathogen detection system, PathTracker, is presented for rapid point-of-care diagnosis through innovative image processing techniques. In the second focus, although test-time …
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A combined microfluidic/dielectrophoretic microorganism concentrator
… microfluidic microorganism concentrator for pathogen detection applications. Interdigitated electrodes lining the bottom of the channel use positive dielectrophoretic forces to trap particles. A passive mixer is used to circulate the liquid in the channel, transporting particles to within the …
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Design methods for sensitive and comprehensive microbial surveillance
… infectious disease diagnostics, proactive pathogen detection and characterization, and microbiome studies. New genomic technologies are transforming microbial surveillance, but face challenges stemming from low concentrations in collected samples and extensive, ever-changing diversity. In …
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Surface enhanced Raman scattering based assays for DNA detection by
… (SERS) based molecular diagnostic assays for the detection of specific DNA sequences have been developed in recent years to compete with the more common fluorescence based approaches. Current SERS assays require either time consuming separation steps that increase assay cost and can also increase …
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Quantitative assessment of methods for bacterial and viral purification and concentration
From water pathogen detection, SARS-CoV-2 detection, to biological weapon detection, the samples we analyze include much more than our target organism. To accurately detect our targets of choice, the use of various labor intensive, and at times costly techniques, have been used to purify and …
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A microfabricated dielectrophoretic micro-organism concentrator
… development of a micro-organism concentrator. Pathogen detection, particularly MEMS based detection, is often limited by sample concentration. The proposed concentrator will interface with a pathogen detector. This type of pathogen concentrator can be useful for many kinds of applications …
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Callus Culture as a Prospective Biosensor: Examining Fusarium graminearum Infection and Exploring the Use of RUBY as a Pathogen-Inducible Reporter
… diseases and a reliance on visual symptoms for detection, agriculturalists face continual challenges in identifying the presence of pathogens with enough lead time for effective mitigation, highlighting a need for novel early plant pathogen detection technologies. This thesis introduces an …
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Coliforms, Salmonella, and Shigella in the James River Basin
… assessed using routine monitoring methods and pathogen detection techniques. Samples were collected from 10 different locations, once per month for 6 months, and analyzed for fecal coliforms, E. coli and total phosphorous. The location, date, flow rate, air temperature, precipitation, water …
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