Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"pathogen clearance"”.
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Metabolic Regulation of Mast Cell Regranulation
… degranulation. MCs have beneficial roles in pathogen clearance and wound healing but are most widely associated with their deleterious effects in allergic diseases. Importantly, MCs have been shown to reform granules following degranulation in vitro. This capacity for multiple cycles of …
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Antigen-specific memory T cell distribution in non-lymphoid tissue
… system cell type responding to intracellular pathogens, particularly viruses, and tumor antigens. In the case of influenza, activated T cells migrate from the mediastinal (draining) lymph nodes to the lung where they perform their cytolytic function. After pathogen clearance, memory CD8+ T …
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Influenza A Virus Induced Programmed Cell Death
… of the lower lung is most correlated with pathogenesis. The mammalian lung has multiple structural cell types, of which two classes are considered most important for IAV pathogenesis. These are (1) alveolar unit cells and (2) cells of the conducting airways, primarily those of the bronchi …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… balancing the need for activation to achieve pathogen clearance with the establishment and maintenance of long-term memory or exhausted T cell responses.
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Behavioral change in response to low-grade non-infectious stimuli: findings and potential neuroimmune mechanisms
Individuals afflicted with a pathogenic infection exhibit symptoms including lethargy, malaise, listlessness, loss of interest in social and environmental surroundings, and anorexia. Together, these symptoms comprise what is recognized as “sickness behavior.” Sickness behavior represents a …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… the protective type 2 immune response, eliciting pathogen clearance, and promoting tissue repair. However, IL-25 and ILC2s have also been associated with inappropriate allergic reactions and autoimmune diseases, while their roles in immune responses to cancer are more poorly understood. Colorectal …
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Neutrophil interactions with Leishmania amastigotes: implications for chronic leishmaniasis
… parasites must be fine-tuned to promote pathogen clearance without triggering excess inflammation, and this requires the concerted efforts of numerous innate and adaptive immune cell types. Neutrophils are a prevalent component of the inflammatory infiltrate during the acute phase (caused …
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Cell Biology of Foxp3+ Regulatory T Cells
… role in the immune response to fight against pathogens and orchestrate other immune cells. An overreactive immune response can lead to autoimmune diseases, therefore the immune system must possess negative regulation mechanisms. In the periphery, naturally arising regulatory T cells (nTregs) …
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Effects of Spaceflight on Phagocytic Function and Immune-Neural Interaction
… of low-dose radiation on the response to a live pathogen. Mice were exposed to 3 Gray (Gy) whole-body proton radiation and were inoculated with <em>Escherichia coli (E. coli)</em>. Changes in leukocyte populations, cytokine secretions, phagocytic activity, bacteria clearance, Major …
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Regulation of Host Immune Responses by Toll-Interacting Protein During Citrobacter rodentium Infection
… can be caused by attaching/effacing (A/E) pathogens like enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC). Citrobacter rodentium (CR), a murine A/E pathogen, mimics EPEC and EHEC infections, causing goblet cell depletion, crypt hyperplasia, and leukocyte infiltration …
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A Mathematical-Experimental Strategy to Decode the Complex Molecular Basis for Neutrophil Migratory Decision-Making
… is crucial for resolution of inflammation and pathogen clearance. It has been recently shown that when pre-conditioned with bacterial endotoxin (LPS), innate immune function can become dysregulated. Neutrophils start to display altered antimicrobial response as well as dysfunctional migration …
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Investigating the role of the Dendritic Cell Immunoactivating Receptor in the Immune Response during Pneumocystis murina
… is initiated by receptors that recognize pathogen associated molecular patterns on the surface of pathogenic fungi. Specifically, C-type lectin receptors (CLRs) have been shown to be the principal initiators of innate immune response during fungal infection. Limited studies have focused on …
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Hybrid Particle-Nonwoven Membrane Materials for Bioseparations
… the initial protein capture and host cell clearance steps; however, many of the currently available methods have shown little efficacy at large-scale. Additionally, interest in the clearance of pathogenic activity, most importantly infectious prions, from blood and blood derived products …
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Elucidating Mechanisms Involved In Host Microbial-Tumor Interactions
… neutrophils into the TME which undergo a pathogen clearance mechanism called Neutrophil Extracellular Trap formation (NETosis) that spatially excluded cytotoxic CD8 T cells. Blockade of IL-17/IL-17RA signaling, neutrophils or NETosis synergized with immunotherapy to reduce advanced PDAC …
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… system is able to detect and respond to invading pathogens. PRRs bind conserved microbial components and subsequently initiate pro-inflammatory defense programs. While effective at eliminating pathogens, these inflammatory responses can have deleterious effects; excessive inflammation can result …
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Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
… Defective neutrophil recruitment can inhibit pathogen clearance, while impaired neutrophil resolution can lead to chronic inflammation. Therefore, it is essential that neutrophil migration is tightly controlled and self-resolving. It was originally thought that neutrophilic inflammation was …
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Antibody-Mediated Modulation of Polyclonal Immune Responses
<p>Upon pathogen exposure, two main lines of defense are sequentially activated: the innate immune response and the adaptive immune response. The innate immune response is the first line of defense, and consists mainly of myeloid cells that are quickly activated within hours to days to engage in a …
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Immunomodulation in Adenovirus-Induced Viral Hepatitis
… in viral hepatitis can range from complete pathogen clearance and recovery of liver function to failure to contain the infection and loss of liver function. Because hepatotropic viruses are one of the major etiologic causes of morbidity and mortality worldwide, there is great interest in …
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The Role of Drak2 in T Cell Function and Autoimmunity
… and ensure that immune cells target foreign pathogens and not healthy cells of the body. However, some immune cells can escape these checkpoints and attack the body’s healthy cells, leading to tissue destruction and devastating autoimmune disorders. For example, multiple sclerosis (MS) occurs …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… into effector T cells which mediate pathogen elimination. During the aftermath of pathogen clearance, a subset of effector T cells revert back to quiescence and differentiate into memory T cells. The Forkhead box O transcription factors FOXO1 and FOXO3 (to lesser extent) are essential …
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