Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"pathobiology"”.
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Pathobiology of glomerular alpha-dystroglycan
Contains fulltext : 89847.pdf (Publisher’s version ) (Open Access)
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Pathobiology of neuroinflammation and basal ganglia circuitry in Parkinson’s Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and the most common movement disorder. A defining pathologic feature of PD is the progressive death of dopaminergic neurons in a basal ganglia nucleus termed the substantia nigra (SN). Another hallmark feature of …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis (TB), is the leading cause of death in people living with Human Immunodeficiency Virus (HIV). Treatment of co-infected persons is challenging due to the aggressive course of both individual diseases, and often is further …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis (TB), is the leading cause of death in people living with Human Immunodeficiency Virus (HIV). Treatment of co-infected persons is challenging due to the aggressive course of both individual diseases, and often is further …
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The Contribution of Spleen Tyrosine Kinase to the Pathobiology of Alzheimer’s Disease
… of the spleen tyrosine kinase (SYK) in AD pathobiology. Syk is wellknown for its involvement in B-cell receptor (BCR) signaling but our previous data have demonstrated that SYK is also involved in tau yperphosphorylation and A-beta production, therefore suggesting that SYK could contribute …
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From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies
Vestibular schwannomas (VSs), the most common tumors of the cerebellopontine angle, arise from Schwann cells of the vestibular nerve. VSs can lead to sensorineural hearing loss (SNHL), disequilibrium, facial nerve paralysis, and brainstem compression. Treatment options available today are …
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Contribution of Causal Aquaporin-1 Mutations to the Pathobiology of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare and debilitating disease characterised by elevated pulmonary arterial pressure and extensive vascular remodelling in the lungs, with a lack of effective curative options. The identification of genetic variations in genes encoding components of the …
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Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide and Cytoskeletal Assembly Dynamics and the Pathobiology of Pulmonary Arterial Hypertension
Background: The regulation of intracellular trafficking between the trans-Golgi network (TGN) and plasma membrane (PM) is vital for protein secretion and growth factor signaling, which involves recycling and PM localization of cell surface receptors. These processes depend on the cytoskeleton and …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… for CTEPH would provide important insights into pathobiology and might allow risk-stratification following PE. A genome-wide association study (GWAS) was performed in 1250 CTEPH patients, 1492 healthy controls and ~7 million single-nucleotide polymorphisms to identify novel disease loci. The ABO …
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NEUROPROTECTIVE THERAPIES CENTRED ON POST-TRANSLATIONAL MODIFICATIONS BY SUMOYLATION
… investment demands a re-evaluation of the pathobiology of ischemic brain injury and a subsequent adjustment of therapeutic approaches. While reductionist methods (e.g. the targeting of single proteins/pathways) have done much to enhance our understanding of ischemic brain injury, …
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A Comparative Study of the Pathology and Pathophysiology of Severe Malaria in a Non-Human Primate Model
… characterize and describe the pathology and pathobiology of the P. coatneyi/Rhesus macaque model. This included a thorough examination of the parasite host interaction, clinical symptomology, hematology and clinical pathology, gross pathology, histopathology, immunohistochemistry, …
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Characterising ATP13A3 biological function and its role in pulmonary arterial hypertension
… uncover additional fundamental mechanisms of PAH pathobiology, our group undertook whole genome sequencing in 1038 idiopathic or heritable PAH patients and identified disease-associated heterozygous mutations in ATP13A3, a P5B-type ATPase. P5 ATPases, namely ATP13A1-5, are putative transmembrane …
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Uncovering functional mechanisms in cancer through integrative genomics
… at extracting new fundamental insights into the pathobiology of cancer. Our genome-centric strategies and resulting cancer discoveries are presented.
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Ultrastructural damages in the brain induced by low-intensity primary blast wave : a transmission electron microscopy study on mild traumatic brain injury
… of primary low-intensity blast (LIB)-mediated pathobiology on neurological deficits requires further investigation. Our prior considerations of blast physics predicted ultrastructural injuries at nanoscale levels. Here, using transmission electron microscopy, we examined the fine structure of …
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Implicación de igf1r en inflamación pulmonar aguda y en alergia inducida por ácaros del polvo doméstico en ratones
… study the implication of IGF1R in chronic asthma pathobiology. On the other hand, inbred C57BL/6 and CreERT2 mice were given daily consecutive doses of HDM extract to study the acute allergic profile and the implication of IGF1R in acute asthma pathobiology. Finally, IGF1R deficiency was …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
… crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small molecule …
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Mining the Medulloblastoma Genome and Transcriptome
… approach, to further our understanding of the pathobiology of medulloblastoma. Finally, we propose rationale therapeutic targets that may improve the treatment of aggressive variants of this disease.
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An Examination of the Roles of CX3CR1 and Microglia in a Mouse Model of Degenerative Cervical Myelopathy
… Moreover, by increasing understanding of DCM pathobiology, this work highlights potential therapeutic targets and may aid in the surgical and peri-operative management of DCM.
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Magnetic Resonance Imaging of Atherosclerosis
… in providing detailed information about plaque pathobiology besides luminal stenosis. Using a special contrast medium called ultrasmall superparamagnetic particles of iron oxide (USPIO), MR imaging can also help in the assessment of carotid plaque inflammation. In this dissertation, I explore …
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