Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"particle fabrication"”.
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Porcine islet encapsulation for treatment of type-1 diabetes using precision particle fabrication method
… second part of the thesis presents single-step fabrication of core/shell alginate microcapsules using precision particle fabrication (PPF) system to demonstrate the feasibility of successful clinical xenotransplantation. PPF system has following capabilities: precise control of capsule size, …
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Uniform double wall microspheres/microcapsules for protein delivery
… (PLG) and poly (lactic acid) (PLA) microparticles such as double-wall/single-wall microspheres and microcapsules were heavily investigated for controlled delivery of small molecule drugs as well as proteins and DNA. The size distribution of protein-loaded biodegradable polymer …
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Modeling of fluids and waves with analytics and numerics
… as multimaterial fiber drawing and multilayer particle fabrication. Motivated by complex multi-fluid geometries currently being explored in these applications, we theoretically and computationally studied capillary instabilities in concentric cylindrical flows of N fluids with arbitrary …
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Uniform biodegradable microparticle systems for protein delivery
… (PLG) and poly(lactic acid) (PLA) microparticles such as double-wall/monolithic microspheres and microcapsules have been heavily investigated for controlled delivery of small-molecule drugs as well as peptides, proteins and DNA. The size distribution of protein-loaded biodegradable …
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Microfluidic synthesis and properties of bio-inspired colloids
Today, custom-tailored polymeric hydrogel microparticles are routinely used for drug delivery, medical diagnostics, as well as many fundamental studies in colloidal science. There is growing consensus that physical attributes, such as size, shape, internal structure, and mechanical deformability, …
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Advanced flow lithography and barcoded particles
Anisotropic multifunctional particles have drawn much attention, leading to wide ranges of applications from biomedical areas to electronics. Despite their enormous potentials, particles with geometrically and chemically complex patterns are not widely used because existing methodologies have …
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Coaxial double-walled microspheres for drug and gene delivery applications
… atomization (CEHDA) and precision particle fabrication (PPF) techniques. Here, we focus on double-walled microspheres consisting of a poly(D,L-lactic-co-glycolic acid) (PLGA) core surrounded by a poly(D,L-lactic acid) (PDLLA) or poly(L-lactic acid) (PLLA) shell layer. The first …
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Investigation of cell-based therapies employing microcapsules and microspheres: encapsulation and controlled release
… for various applications. Novel precision particle fabrication (PPF) was employed to prepare MSs and MCs with controlled size and uniformity which are critical parameters in the release kinetics of drugs including therapeutic proteins and cells. Furthermore, core/shell MCs containing …
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Study of drug delivery and cell encapsulation using biocompatible hydrogel
Hydrogel particles encapsulating biomolecules or living cells are becoming an attractive means to mediate drug delivery or facilitate cell-based treatment of diseases. These particles are capable of maintaining drug stability/cell viability and providing specific drug release profiles. The …
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Engineering translational multi-therapeutic targeted delivery vehicles for disease management
… to coat materials atop drug-loaded PLGA nanoparticle substrates that control drug release and nanoparticle pharmacokinetics in a systemic environment. In Chapter 3, we incorporate ligand-functionalized materials atop a drug-loaded liposomal core to promote tissue-level specificity for …
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Impact and melting dynamics of micron-sized particles on a liquid pool
… impact and subsequent melting of paraffin wax particles (melting point: ≈60°C, diameter: 200-800 μm, impact velocity: 0.3-1.9 m/s) onto a pool of liquid paraffin with temperatures 100-130<sup>o</sup>C was investigated. The micron-sized paraffin particles were created using a bulk emulsion …