Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"particle engineering"”.
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Combined wet milling crystallisation methods for particle engineering
… dry solids processing facility for adjusting the particle size and shape attributes of crystalline products for downstream processing. An emerging and increasingly applied technology is high shear wet milling in crystalline slurries for inline size and shape modification during particle formation. …
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Particle engineering via surface modification during micronization for pharmaceutical applications
… allow for micronizing the API. In this work, dry particle coating technique is investigated in the context of micronizing API powders and overcoming problems associated with the micronized fine powders due to their strong cohesive forces. Consequently, the main objective of this dissertation is to …
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Particle Engineering via Spray Freeze-Drying for Pulmonary Drug Delivery Applications
L'abstract è presente nell'allegato / the abstract is in the attachment
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EXPLORING HETEROSTRUCTURED UPCONVERSION NANOPARTICLES: FROM RATIONAL PARTICLE ENGINEERING TO BIOMEDICAL APPLICATIONS
Upconversion nanoparticle (UCNP)-based photodynamic therapy (PDT) with unique anti-stokes luminescence features are of great interest. UCNP-based PDT affords greater tissue penetration depths than that of visible lights and serves as suitable nanoplatforms carrying photosensitizers as well. …
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Quality by Design Approach to Advanced Particle Engineering, Process Optimisation and Upscaling of Electrohydrodynamic Atomisation Technology
Particle engineering for drug delivery (DD) has gained enormous research interests in recent years, with continuous development of new technological platforms and improvement of existing ones. Unlike most other technologies, the electrohydrodynamic atomisation (EHDA), has been shown to have more …
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Multiphase, Multicomponent Systems: Divalent Ionic Surfactant Phases and Single-Particle Engineering of Protein and Polymer Glasses
… liquid medium, and can serve as direct single-particle studies of drug delivery systems that are formed using solvent extraction (e.g., protein encapsulated in a biodegradable polymer), and as model systems with which to study the materials and principles that govern particle formation. The …
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Control of crystalline particle properties by spray drying
… manufacturing can offer an extensive array of particle engineering applications. Continuous manufacturing aims to deliver consistent and sustainable drug products of a better and higher quality. Spray drying is a continuous processing technique typically adopted for amorphous solid production. …
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Formation of optimised particles for formulation and processing
… to enhance processing characteristics. Novel particle engineering techniques such as spherical crystallization or spherical agglomeration can be used in order to obtain spherical agglomerates with enhanced properties. Spherical agglomerates are produced through cooling crystallization in …
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Engineering of composite pharmaceuticals with improved physicochemical and mechanical properties
… the granulation techniques, co-processing using particle engineering techniques has recently become the preferred approach to improve powder physicochemical properties for DC to produce high-quality tablets that can serve the intended therapeutic purpose. Therefore, in this project, composite …
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Polymeric Nanocarriers And Their Oral Inhalation Formulations For The Regional Delivery Of Nucleic Acids To The Lungs
… tissue, and formulation challenges - aerodynamic particle size, surface chemistry of the particles, and solvation forces in propellant/co-solvent mixture. In light of the challenges and opportunities described above, we propose in this work: (i) a quantitatively and systematically evaluation of …
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Novel Technology for Crystal Engineering of Pharmaceutical Solids
… Sub-Critical water (MASCW)" technology for particle engineering of active pharmaceutical ingredients and excipients was developed. The present novel technology MASCW process is described as green technology as water is used as the solvent medium and microwave energy as external source of …
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Measurement, optimisation and control of particle properties in pharmaceutical manufacturing processes
The understanding and optimisation of particle properties connected to their structure and morphology is a common objective for particle engineering applications either to improve materialhandling in the manufacturing process or to influence Critical Quality Attributes (CQAs) linkedto product …
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Engineering of Inhalation Aerosols Combining Theophylline and Budesonide
… seems rational to combine both substances in one particle. This type of particle has the advantage over a combination product containing both drugs in a physical mixture which occurs rather randomly deposition leading to API segregation and non-dose-uniformity. Dry powder inhalers (DPIs) is a type …