Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"particle design"”.
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MULTI-SCALE MODELING OF HIGH-SHEAR GRANULATION
High shear wet granulation is a particle design process used to increase the size of a primary powder material through the addition of liquid binder. This thesis focuses on the multi-scale nature of high-shear granulation in order to understand behavior changes due to coupled consolidation and …
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Synthesis of biodegradable hydrogel microparticles for vaccine protein delivery
… example, it has been shown that micro- and nano-particle mediated delivery of protein antigen can use up to 100 times less protein and still produce an effective immune response [1]. In order to use this phenomenon to make vaccines more efficient, we need a biodegradable delivery particle. This …
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Scattering design : absorption enhancement and frequency selective metasurfaces
In this work, we develop frameworks to study and design the scattering properties in two kinds of systems. For the first problem, we find approximate angle/ frequency-averaged limits on absorption enhancement due to multiple scattering from arrays of "metaparticles", applicable to general …
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Measurement, optimisation and control of particle properties in pharmaceutical manufacturing processes
The understanding and optimisation of particle properties connected to their structure and morphology is a common objective for particle engineering applications either to improve materialhandling in the manufacturing process or to influence Critical Quality Attributes (CQAs) linkedto product …
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Antiferromagnetic nanodiscs with perpendicular magnetic anisotropy for biological applications
Abstract Magnetic particles have been widely implemented across research areas in liquid and biological environments, such as cancer therapy, drug delivery and cell sorting. Perpendicularly magnetised (PM) synthetic antiferromagnetic (SAF) particles exhibit a range of desirable properties that make …
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On Applications of Resonances, from One to Infinity
… integration. We then present analytical design criteria for multi-resonant filters in strongly coupled systems where standard approaches (such as coupled mode theory or network synthesis) are not adequate. For this, we develop a quasi-normal mode theory (QNMT) of the scattering matrix …
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Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine
… on polymerase chain reaction (PCR), suspension (particle-based) arrays offer several advantages in the multiplexed detection of biomolecules, including higher rates of sample processing, reduced consumption of sample and reagent, and rapid probe-set modification for customizable assays. This …
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Physics of Hexagonal Limit-Periodic Phases: Thermodynamics, Formation and Vibrational Modes
… exhibit LP phases. The particular 3D models were designed such that next-nearest-neighbor interactions of the TS type are implemented using only nearest-neighbor interactions. For one of the 3D models, we show that the phase transitions are first order, with equilibrium structures that can be more …
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Study of Particle Formation using Supercritical CO2 as an Antisolvent
Particle design using supercritical CO2 has been of great interest in the pharmaceutical, microelectronic, catalytic, and related industries over the past 10 years. There have been numerous papers and patents published on the processes studied in this work. The solubility of most drug compounds in …