Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"partial hepatectomy."”.
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Albumin metabolism following partial hepatectomy in the rat
… five aspects of albumin metabolism following partial hepatectomy in the rat. 1. The plasma albumin levels following partial hepatectomy. 2. The effect of partial hepatectomy on the albumin synthesis rate. 3. The effect of supplementary amino acids on the albumin synthesis rate following …
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PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
… response of the liver following resection. After partial hepatectomy in mice, there is an increase in PI3K activity; total PI3K blockade with wortmannin, and selective inhibition of p85ƒÑ or p110ƒÑ with siRNA resulted in a significant decrease in hepatocyte proliferation, especially at the …
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Manipulating macrophages to enhance liver regeneration
… use of mouse models of liver injury including partial hepatectomy, partial hepatectomy plus chronic liver injury and paracetamol intoxication. I show the development of liver function assays in these models including quantification of hepatic clearance of indocyanine green by fluorescent …
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A review of living donor liver transplantation: why is regeneration more rapid in the recipient compared to the donor?
… the remnant donor liver and the transplanted partial liver to undergo liver regeneration. However it has been demonstrated that liver regeneration in the recipient is rapid, whereas restoration of liver mass in the donor is delayed. This discrepancy in the rate of regeneration could be due to …
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Role of the IKK complex during liver regeneration
… complex in the context of liver regeneration. Partial hepatectomy (PH) in IKK2dhepa mice led to a delayed and reduced NF-kB activation. Consequently, the proinflammatory cytokine TNF-alpha was strongly induced earlier in IKK2dhepa mice and the Acute Phase Response marker SAA showed an early and …
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Cellular and molecular mechanisms of liver regeneration
… hepatocyte proliferation and liver regeneration. Partial hepatectomy was used as an experimental model of liver injury and regeneration. It was performed in mice, in which one or more αv integrins had been genetically depleted from specific cell types in the liver, namely hepatocytes, hepatic …
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Genregulation des Zellzyklusmediators Cyclin E2 in humanen und murinen Hepatomzellen
… vivo-samples of mice segregated before and after partial hepatectomy showed furthermore that at least five protein-complexes bind cell cycle-dependent this highly-regulated sequence. In vitro-mutagenesis of the detected E2F-binding site surprisingly caused a higher promotor activity, which …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
… that hepatocyte proliferation following partial hepatectomy (PH) can be attenuated by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that is involved in hepatic organogenesis and cell cycle control. This growth suppression suggests that AhR modulates critical …
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P53 Maintains Hepatic Cell Identity During Liver Regeneration
… surgery-induced liver regeneration. Two-thirds partial hepatectomy (PH) of mouse liver offers a unique model to compare p53 functions in regenerating versus sham (control) cells. My <strong>hypothesis</strong> is that intersection of global expression analyses (microarray and RNA sequencing) and …
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Cell cycle regulation in the liver : differential functions of E-type cyclins E1 and E2 for G1/S-phase transition and endoreplication in mice
… cells into the cell cycle in vivo. In the partial hepatectomy (PH) model it was shown that cyclin E1-/- deletion results in normal liver regeneration with slight delay of G1/S-phase transition but absent endoreplication in hepatocytes. In contrast, cyclin E2-/- mice showed over-expression …
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Molecular analysis of the role of Caspase-8 during liver regeneration and tumorigenesis
… priming phase of liver regeneration following partial hepatectomy (PH) which directly contributes to gene activation of Cyclin D via NF-kappaB, c-Jun/ AP-1 and E2F1. The aim of the present study was to investigate the consequences of Caspase-8 deletion for TNF signaling during liver …
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Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
… (TCDD) following 70% partial hepatectomy (PH). One reported target of the AhR that may account for suppression of the regenerative response is plasminogen activator inhibitor-1 (PAI-1), which negatively regulates the cleavage and activation of hepatocyte growth factor …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… to surgical removal of ~2/3 of liver mass (partial hepatectomy, PH), the remaining hepatocytes exit G0 of cell cycle and undergo proliferation to reestablish liver mass. The hypothesis tested in this work is that p53/p73 functions in cell cycle arrest, apoptosis and senescence are repressed …
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The role of neurofilament-light polipeptide (NEFL) in the onset and progression of hepatocellular carcinoma
… liver regeneration occurring following two/third partial hepatectomy (PH), suggesting that NEFL expression in the liver is a specific feature of cancer onset and development. The ectopic expression of NEFL at all stages of rat carcinogenesis implies that NEFL may function as an oncogene in the …
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Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation
… in hepatocytes. After liver resection by partial hepatectomy (PH) the deletion of gp130-dependent signalling had major impact on acute phase gene (APG) regulation. APG expression was blocked in gp130-STAT animals. In contrast, gp130-Ras mice showed an enhanced APG response and a stronger …
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Serial Analysis of Gene Expression of Rat Liver Regeneration by Oval Hepatic Stem Cells
Die Leber besitzt die einzigartige Fähigkeit der Selbstregeneration nach Schädigung. Adulte Hepatozyten sind in der Lage, in der normalen Leber, ein perfektes Gleichgewicht zwischen Zellzuwachs und Zelluntergang aufrecht zu erhalten. Bei Schädigung des Lebergewebes können sie durch ihre Fähigkeit …