Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"paromomycin"”.
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Studies using luciferase-expressing Leishmania donovani parasites
… stibogluconate, amphotericin B, miltefosine and paromomycin. Intraperitoneal or bone marrow derived macrophages infected with L. donovani were incubated with different concentrations of each drug (sodium stibogluconate, 4-0.02mg/ml; amphotericin B, 4-0.02μg/ml: miltefosine, 4-0.02μg/ml; …
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Trans-Acting Factors Affecting Retroviral Recoding
… the MoMLV gag-pol junction. We show that G418, paromomycin and PTC124 increase readthrough of our MoMLV reporter in a dose dependent manner in 293A cells. These drugs reduce viral replication, as measured by a recombinant transducing virus assay. We further examine G418 and paromomycin in an …
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Cloning of a <i>CHLAMYDOMONAS REINHARDTII</i> Marker into a RNA Interference Construct to Test Whether the Photoreceptor Chlamyrhodopsin Is Involved in Circadian Clock Resetting
… marker conferring resistance to the antibiotic paromomycin was cloned into a COP RNAi construct obtained from another lab. Firstly, the COP RNAi construct was restriction digested to linearize it. The linearized plasmid was then blunt ended with T4 DNA polymerase and dephosphorylated with …
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Cryptosporidium and Giardia in calves in Belgium
… experimental study to evaluate the efficacy of paromomycin sulphate, and in a field efficacy study to evaluate a combination of treatment with fenbendazole and environmental measures. Both paromomycin and fenbendazole significantly reduce cyst excretion, although in natural conditions …
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30S Ribosomal Subunit Assembly is a Target for Inhibition by Aminoglycoside Antibiotics in <em>Escherichia coli</em>.
… effect. I used the aminoglycoside antibiotics paromomycin and neomycin, which bind specifically to the 30S ribosomal subunit. Both antibiotics inhibited the growth rate, viable cell number, and protein synthesis. I used a <sup>3</sup>H-uridine pulse and chase assay to examine the kinetics of …
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Exploring conformational variability of an rna domain in the ribosome: from structure and function to potential antibiotic targeting
… of aminoglycoside antibiotics neomycin and paromomycin also show conformational variability in H69. These results indicate that H69 exists in multiple conformational states, which could be related to the function of the ribosome in the cell.</p>
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An Investigation of Bacterial Ribonucleases as an Antibiotic Target
… an increased sensitivity to neomycin and paromomycin antibiotics. My research has also shown that an inhibitor of RNases, vanadyl ribonucleoside complex, potentiated the effects of an aminoglycoside and a macrolide antibiotic in wild type <em>Escherichia coli</em>, methicillin sensitive …
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Investigating the molecular basis of vitamin B12 uptake in Chlamydomonas reinhardtii
… mutagenesis. A reporter line was made with a paromomycin-resistance marker under control of a B12-repressible promoter, so that it showed repression of growth in paromomycin under high media vitamin B12 concentrations (+P+B12). As this line was thought to respond to intracellular B12 only, the …
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Method Development And Applications To Screening And Characterization Of Rrna-Targeting Small Molecules
… has a similar binding site as the antibiotic paromomycin. DMS chemical probing results also suggest that the binding of DHR23 to the A site leads to stabilization of the stacked-in conformation of A1492 and A1493.</p> <p>To aid in the ligand identification process, a modified FID assay for …
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Investigation towards the role of LmxOSM3.1 phosphorylation and the identification of its interaction partners using an improved method of proximity labelling
… antimonials, amphotericin B, miltefosine, paromomycin, and pentamidine. Unfortunately, they do not come without limitations, hence, more effective treatments are needed. Kinases and kinesins have been shown to be promising drug targets.;LmxOSM3.1 is expected to be a plus end-directed …
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Evaluation of hops essential oil cytotoxicity and anti-cryptosporidium activity
… activity compared to other drugs used such as paromomycin (IC50= 277 µg/mL) and nitazoxanide (IC50= 10 µg/mL) as shown in the literature. The encapsulation efficiency of HEO was 78.1%. The particle sizes of HEO and myrcene in β-CD complexes were lower than uncomplexed β-CD. Significance. HEO …
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An in-vitro study investigating current and novel antimicrobial agents as potential topical treatments for cutaneous infections caused by bacteria, fungi and Leishmania
… membranes of each organism. Chlorhexidine and paromomycin were encapsulated in Lipodisq®, a specialised lipid nanoparticle. The efficacy of these compound-Lipodisq® formulations was assessed using MIC, MBC, time-kill, and EC50 assays. Results Polyhexamethylene biguanide (PHMB) is a widely used …