Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"parkinsonism"”.
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Neuronal and Mitochondrial Protection in Chronic Parkinsonism
Among the several plausible neuropathological hypotheses underlying the progression of aging and neurodegenerative diseases such as Parkinson’s disease (PD), oxidative stress and mitochondrial damage have emerged as one of the attractive biochemical mechanisms. However, most of the past studies …
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Imaging and fluid biomarkers in uncertain cases of parkinsonism
Contains fulltext : 292988.pdf (Publisher’s version ) (Open Access)
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Structure-function studies of the Parkinsonism-linked protein DJ-1
… we sought to determine the impact of a Parkinsonism-linked A107P mutation on DJ-1 structure and glyoxalase activity. The A107P variant abrogates the ability of DJ-1 to protect against glyoxal-induced cytotoxicity and carboxymethyllysine protein modification. A crystal structure of DJ-1 …
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Signalling pathway of FBXO7 and its role in hereditary Parkinsonism
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s and old age is the strongest risk factor for developing PD. PD has traditionally been seen as a motor disorder, but its non-motor symptoms such as dysautonomia, sensory dysfunction, sleeping problems and …
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Patterns and biomarkers of X-linked dystonia parkinsonism disease progression
X-linked dystonia parkinsonism is a neurodegenerative movement disorder that originate from the island of Panay, Philippines. Though this is a relatively novel disease, efforts have been directed towards solving the etiology, which currently points to an expansion in the TAF1 gene. This gene plays …
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Parkinson's disease and degenerative parkinsonism: relationship between clinical and neurobiological aspects
Il neurovascula coupling indica il processo mediante il quale l unità neuro vascolare modula la complessa relazione tra attività neuronale, fattori emodinamici e segnali intracellulari. Recenti studi individuano la possibile associazione tra alterazioni dell emodinamica cerebrale e il decadimento …
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Synthetic and Natural Environmental Compounds as Potential Facilitators of Mptp-Induced Parkinsonism
Parkinson's disease (PD) is a neurodegenerative Lewy body disorder characterized by severe motor deficits, followed by cognitive dysfunction with progression of the disease. Environmental exposure has been suggested as a possible contributor to the development of PD and this view is linked to the …
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Role And Impact Of The Gut Microbiota In A Drosophila Model For Parkinsonism
… axis in Drosophila models of autosomal recessive parkinsonism and observed a five-fold increase in the gut microbial load of aged parkin animals. The microbial load of pink1 animals was unchanged, suggesting a Pink1-independent role for parkin in maintaining microbial load numbers within normal …
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Comparative merits of stramonium, belladonna, genoscopolamine, and hyoscine, in the treatment of post-encephalitic Parkinsonism
The following thesis is based on a series of researches carried out by the author at the London County Mental Hospital, West Park, Epsom, on the drug treatment of the post -encephalitic Parkinsonian state, in a series of 65 cases.
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A study of the response of two patients with Parkinsonism to doses of ascorbic acid and thiamine
Thesis (M.S.)--Michigan State University of Agriculture and Applied Science. Dept. of Food and Nutrition, 1956
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Examining the relationship between mitochondrial dysfunction and Parkinson's disease pathology: a review on potential risk factors and treatments for parkinsonism
… association between defective mitochondria and parkinsonism. With a focus on improving mitochondrial function and reducing Parkinson’s disease pathology, a number of potential drug treatments and therapies have proven to be of interest. While there is currently no cure for Parkinson’s disease, …
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Heredity in Parkinson's disease. From rare mutations to common genetic risk factors.
… genetic causes of Parkinson's disease (PD) and parkinsonism in southern Sweden. The extensive Lister Family with parkinsonism caused by duplications and triplications of the gene for alpha-synuclein (SNCA) was studied. Clinical, genetic and genealogical data were compiled and evaluated. …
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Behaviour of single motor units in human skeletal muscle
… in voluntary contraction. In hypertonie Parkinsonism, however, increments of voluntary contraction are presumably largely dependent on recruitment of extra units. Certainly the units recorded in the present study showed a very marked tendency to fire at unusually slow rates. They did so …
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Beans, roots and leaves
… review of the pharmacological therapy of parkinsonism from ancient times until the near present (1980). It is not clear whether parkinsonism as it is now defined – a progressive neurodegenerative disorder of the basal ganglia characterized by sharply reduced striatal dopamine levels, …
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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
… (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model. In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria of dopaminergic neurons, resulting in …
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Effects of MPTP, MPP(+) and Adreno-Medullin on Dopamine Metabolism in the Rat Corpus Striatum
… a contaminant on illicit narcotic drugs, causes parkinsonism symptoms in drug addicts. Also, systemic injections of very low doses of MPTP in non-human primates produces selective destruction of the nigrostriatal dopamine neuron and severe motor impairments. That peripheral administration of a …
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Functional and Pathophysiological-morphological Correlates of Neurodegenerative Diseases
… optical coherence tomogra- phy; parkinsonism; respiratory chain complex; retinal nerve fiber layer thickness
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Cell death of reelin secreting nNOS positive GABAergic interneurons in the hippocampus of P301L trangenic mice
… 본 연구에서는, FTDP-17 (Frontotemporal dementia and parkinsonism linked to chromosome 17) 질환 모델로서 Tau 단백질의 과인산화를 유도한 P301L 생쥐를 이용하여 해마 (hippocampus)에서 reelin과 nNOS를 공동으로 발현하는 GABA성 신경세포의 세포사멸에 대해서 알아보고자 했다. 이중면역조직화학법을 이용하여 P301L 생쥐의 해마에서 nNOS를 발현하는 신경세포가 GABA성 신경세포의 한 종류라는 것을 GABA의 마커인 GAD67을 통하여 …
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