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Showing 1 to 20 of 32 for “"parathyroid hormone (PTH)"”.
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Role of Vitamin D receptor and vitamin D binding protein restriction fragment length polymorphisms in determining dose response to vitamin D: a randomized double blind placebo controlled trial
… to vitamin D in terms of serum 25OHD and serum parathyroid hormone (PTH). | We used specimens from an ongoing study (ViDOS - vitamin D supplementation in older subjects) - a double blind randomized placebo-controlled trial that enrolled 160 healthy Caucasian postmenopausal women, with vitamin D …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… 4 (Nmp4) attenuates the response to intermittent parathyroid hormone (PTH) in healthy and ovariectomized (OVX) female mice using a global knockout of the Nmp4 gene. Additionally, these mice have increased bone marrow osteoprogenitors and CD8+ T-cells which support osteoblast differentiation. The …
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Structural Analysis of Dna Complementary to Bovine Parathyroid Hormone Messenger-Rna and Restriction Endonuclease Mapping of the Parathyroid Hormone Gene
… and regulated expression of the gene for parathyroid hormone (PTH), full length single and double stranded DNA complementary (cDNA) to bovine PTH mRNA was synthesized by reverse transcriptase and E. coli DNA polymerase I. Single stranded cDNA migrated as a single discrete band of 750 …
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The effect of continuous infusion of human parathyroid hormone on bone architecture in female mice
… to create an animal model of secondary hyperparathyroidism through continuous infusion of parathyroid hormone (PTH) in adult female mice, and to subsequently study the catabolic effects of PTH. Osmotic pumps were implanted subcutaneously and infused either vehicle, 40 pg/kg/day of PTH or 80 …
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Parathyroid hormone, calcitonin, serum and milk minerals in the periparturient dairy cow
… 21 days prepartum through 21 days postpartum for parathyroid hormone (PTH), calcitonin (CT), Ca, magnesium (Mg), and phosphorus (P) analysis. Heifers and cows receiving the high Ca ration prepartum tended to have higher prepartum serum Ca. Cows fed the high Ca ration prepartum (hi-Ca cows) …
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Calcium metabolism and breast cancer risk
… suggests that calcium and its regulating hormones, i.e. vitamin D and parathyroid hormone (PTH), affect breast cancer risk. The associations between serum calcium levels and breast cancer risk, between serum calcium levels and known risk factors of breast cancer, and between serum calcium …
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Model-Guided Transdermal Formulation of 1α,25-Dihydroxyvitamin D3 for Improved Safety and Efficacy
… effects in the suppression of the parathyroid hormone (PTH) in CKD mice in vivo for the correction of secondary hyperthyroidism (SHPT) without notable toxicity. In conclusion, our transdermal 1,25(OH)2D3 delivery system provides a safe and effective way for the delivery of …
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Modulation Of Renin Secretion By Renal Cortical Interstitial Calcium
… bordered by the renal cortical interstitium, and parathyroid hormone (PTH) positively regulates the concentration of calcium in the renal interstitium. Thus, we hypothesized that hypercalcemia inhibits PRA via PTH-mediated increases in renal cortical interstitial Ca that act on the CaSR triggering …
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Interactions Between Aging and Chronic Kidney Disease on the Skeleton
… both suppression of CKD-induced elevations in parathyroid hormone (PTH) and anabolic therapy to infill cortical pores. Romosozumab, a humanized monoclonal sclerostin antibody, uses PTH-independent mechanisms to increase osteoblast activity, making it an attractive therapeutic for CKD. CKD was …
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Wnt signaling in zebrafish fin regeneration : chemical biology using a GSK3β inhibitor
… such as osteoporosis. Currently, intermittent parathyroid hormone (PTH) treatment is the only approved therapy in the United States for anabolic bone growth in osteoporosis patients. The anabolic effects of PTH treatment are due, at least in part, to modulation of the Wnt/β-catenin pathway. …
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Parallel effects of signal peptide hydrophobic core modifications on cotranslational translocation and posttranslational cleavage by purified signal peptidase
… in nature. The hydrophobic core of the parathyroid hormone (PTH) signal peptide is composed of 12 contiguous hydrophobic amino acids. Although the exact role of the core in signal peptide function is not well defined, particularly in mammalian systems, its length and hydrophobicity have …
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Characterizing the Development of Secondary Hyperparathyroidism and Vitamin D Resistance in Experimental Chronic Kidney Disease
The parathyroid gland (PTG) responds to alterations in calcium and phosphate via secretion of parathyroid hormone (PTH) that acts on kidneys and bone to regulate mineral homeostasis. Hallmarks of chronic kidney disease (CKD) include increased retention of phosphate (PO4) and decreased renal …
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Approaches to Improve the Structure and Function of the Skeleton in Chronic Kidney Disease
… is largely driven by chronically high levels of parathyroid hormone (PTH), which alters the balance of bone remodeling in favor of rampant osteoclast activity and bone resorption. Restricting cortical bone deterioration and the development of cortical pores is likely essential to improve CKD …
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Molecular and Pharmacological Characterization of the Rat RAMP2B Splice Variant
… cyclase activating peptide (VPAC) receptor 1, parathyroid hormone (PTH) receptor 1 and glucagon receptor. An adrenomedullin receptor (AM2) is also formed by the RAMP3 and CL complex. A partial sequence of a rat RAMP2 splice variant was previously identified in our laboratory. I hypothesized …
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Influência da variação sazonal no status de 25-hidroxivitamina D de adultos com síndrome metabólica de uma região do Brasil com elevados índices de radiação ultravioleta
… waist-hip ratio (WHR), waist circumference (WC), parathyroid hormone (PTH) level, total serum calcium level, and diet levels of calcium and vitamin D. The potential predictors for the 25OHD levels were investigated using 16 univariate linear regression models and seven multiple regression models. …
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Parathyroid hormone and calcium interactions in the periparturient mare
… to responses of serum concentrations of Ca and parathyroid hormone (PTH) that may be influenced by dietary Ca. Eight light mares from Farm A and eight Thoroughbred mares from Farm B were bled and milked 10 d pre-foaling, and eight mares (four from each farm) were bled and milked 5 d …
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Osteoporosis in elderly women; Bone traits, fracture and the PTH gene complex
… factors account for approximately 70-80%. Parathyroid hormone (PTH) is the key regulator of calcium homeostasis in the human organism and in addition a powerful skeletal anabolic agent when administered as a drug. Dual energy X-ray absorptiometry (DXA) is the standard method for assessing …
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Changes of parathyroid hormone and vitamin D metabolites according to glomerular filtration rate in chronic kidney disease patients
… are addressed and treated. While secondary hyperparathyroidism develops during the early stages of chronic kidney disease, few patients are evaluated for elevations in serum parathyroid hormone (PTH) before they become frankly hypocalcemic. Quantification of the prevalence of these abnormalities …
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Pre-operative localization and surgical outcomes for primary hyperparathyroidism (PHPT): An 11-year review at a South African hospital
Introduction: Primary Hyperparathyroidism (PHPT) is characterized by hypersecretion of PTH leading to hypercalcaemia with successful surgery being the only definitive cure. Broadly, three techniques of parathyroidectomy exist: open bilateral neck exploration and minimally invasive …
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Control of Hepatitis B and C virus infection in chronic haemodialysis patients
… and B cell inhibition by elevated levels of parathyroid hormone (PTH) as possible mechanisms for the reduced response in dialysis patients. Other factors which have been associated with this poor response include increased age, male gender, specific human leukocyte antigens, shorter time on a …
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