Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"parasitophorous vacuole"”.
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Recruitment and function of ORP1L on the Coxiella burnetii parasitophorous vacuole
… intracellular niche, a large, lysosome-like parasitophorous vacuole (PV), is essential for bacterial survival and replication. There is growing evidence that host cell cholesterol trafficking plays a critical role in PV development and maintenance, prompting an examination of the role of …
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A light and electron microscope investigation of the host-parasite relationship in the brains of mice with congenital toxoplasmosis.
… Interior to this layer was a much convoluted parasitophorous vacuole membrane; exterior was the host cell membrane. In most cases, synaptic plates were noted on the outer plasma membrane. In no instance were tissue cysts observed either within neuroglial cells or in the absence of a host cell. …
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Characterization of a glycerophosphodiester phosphodiesterase in the human malaria parasite Plasmodium falciparum
… of PfGDPD within the parasite cytosol, parasitophorous vacuole and food vacuole. To gain insight into the role of PfGDPD, sub-cellular localization was modulated and resulted in a shift in protein distribution, which elicited no growth phenotype. Kinetic analyses suggest PfGDPD activity …
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Toxoplasma gondii-mediated Host Cell Transcriptional Changes Lead to Metabolic Alterations Akin to the Warburg Effect
… its intracellular niche – a membrane-bound parasitophorous vacuole – T. gondii is nevertheless able to subvert a variety of host cell processes to allow its continued survival and replication. This includes modulation of host signalling processes as well as the scavenging of nutrient …
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Structural and functional studies of heme binding proteins toward the understanding of malaria
… malarial ferrous protein, that is found in the parasitophorous vacuole of Plasmodium. The second is mRuby2, a fluorescent probe often utilized in biological work to track the localization of proteins. Herein, we report on the novel heme-binding properties of both proteins. We have identified a …
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Characterization of a Putative Acid Phosphatase in Toxoplasma Gondii and Its Role in Parasite Propagation
… itself with host cell membrane to form a parasitophorous vacuole (PV), within which it freely divides. To endure the intracellular environment of a host cell, Toxoplasma secretes a large repertoire of proteins beyond the PV to manipulate important host cellular functions. How these …
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With No Gly-Loop Family of Kinases
… within a protective organelle called the parasitophorous vacuole (PV). The PV is filled with a network of tubulated membranes, which are thought to facilitate trafficking of effectors and nutrients. Despite being critical to parasite virulence, there is scant mechanistic understanding of the …
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Modulation of innate immune signaling pathways by the intracellular pathogen Toxoplasma gondii
… interface with its cellular target after the parasitophorous vacuole is formed. A deeper knowledge of how and why Toxoplasma modulates these processes will help us to understand more about the basic signaling pathways themselves and to discover clues on how to better treat Toxoplasma …
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Cryptosporidium Uses Its Cspv1 Virus to Activate Host Type I IFN Response and Attenuate IFN-Gamma-Mediated Epithelial Anti-Parasitic Defense
… but extracytoplasmic position inside a parasitophorous vacuole, rendering intestinal epithelial cells the major battleground between parasite and host anti-parasitic defense. Interferon (IFN) family is a group of cytokines that play essential roles in host innate and adaptive immunity …
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The Effects of Synthetic and Naturally Occurring Compounds on Microsporidian Infection in Insects
… sensitivity. Species forming a sporophorous vacuole (envelope of spore origin) are insensitive while species forming a parasitophorous vesicle (envelope of host origin) are susceptible. Among species producing free spores no trend was discernible; both sensitivity and insensitivity were …
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Evasion of interferon-gamma responses by Toxoplasma gondii in murine and human fibroblasts
… the IFN[gamma] response because they disrupt the parasitophorous vacuole (PV). However, Toxoplasma secretes the contents of apical secretory organelles into the host cell during invasion, and some of these proteins strain-specifically promote mouse virulence by inactivating the IRGs. Here, we show …
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Deciphering host-parasite molecular networks mediating resistance to toxoplasma gondii
… rat inhibits proliferation of T. gondii within parasitophorous vacuoles (PV) in peritoneal macrophages, a phenomenon linked to rapid death of both parasites and infected host cells. The resemblance in progression of toxoplasmosis between rats and humans, and the refractoriness of the LEW rat to …
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Molecular Interactions between Apicomplexan Parasites and their Host Cells
… trafficking by rerouting host vesicles to their parasitophorous vacuole, although with differing specificities. Our extensive RNA-Seq analysis throughout the P. berghei liver stage revealed that hundreds of parasite genes, including some coding for putative exported proteins, are differentially …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… investigates the function of interferon gamma in vacuoles, namely Salmonella enterica serovar Typhimurium and Toxoplasma gondii. IFN-γ is a cytokine that functions in both the innate and the adaptive immune responses. IFN-γ is mainly secreted by T cells and natural killer (NK) cells and activates …
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Purine transport in plasmodium falciparum
… render both the erythrocyte membrane and the parasitophorous vacuole membrane permeable to solutes, allowing transport to be measured across the parasite membrane. The data obtained from the uptake assays were analysed using Michaelis Menten plots to obtain the kinetic properties (Km and Vmax) …
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New approaches to understanding the interactions between Plasmodium falciparum merozoites and human erythrocytes during invasion
… which passes around the merozoite, forming the parasitophorous vacuole. This process has been studied in detail for decades and as a result, we know a lot about the molecular components involved. However, dissecting the precise role of individual proteins has, to date, been limited by the …
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Die parasitophore Vakuole des Mikrosporidiums Encephalitozoon cuniculi: Biogenese und Metabolitaustausch
Mikrosporidien besitzen einen einzigartigen Invasionsmechanismus, bei dem ein so genannter Polartubulus explosionsartig aus der Mikrosporidien-Spore geschleudert wird. Das bisherige Infektionsmodell postuliert, dass der Polartubulus beim Herausschleudern die Plasmamembran einer benachbarten …