Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"parasitic disease"”.
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Pathological and physiological relationships of parasitic disease in a select cottontail rabbit population
Forty-seven cottontail rabbits, Sylvilagu floridanus, were used in a 2 x 2 factorial experiment to determine the effects of parasite reduction on host physiology. Rabbits were treated with insecticide-generating collars (Sergeant's Sentry Dog Collar) and a broad spectrum antihelminth drug …
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Movements, Resource Selection, And Risk Analyses For Parasitic Disease In An Expanding Moose Population In The Northern Great Plains
… of moose, including the potential effects of parasitic disease. I used global positioning system collars to estimate home ranges and habitat selection and collected fecal samples for diet estimates. I reviewed historical data and examined livers moose for evidence of <em>F. magna</em> …
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Purification and characterisation of plasmodium falciparum Hypoxanthine phosphoribosyltransferase
Malaria remains the most important parasitic disease worldwide. It is estimated that over 500 million infections and more that 2.7 million deaths arising from malaria occur each year. Most (90%) of the infections occur in Africa with the most affected groups being children of less than five years …
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Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity
Malaria remains one of the largest parasitic disease burdens worldwide, with the vast majority of that burden occurring on the African continent. The ongoing high number of malaria cases and deaths is in part attributable to the emergence and spread of resistance to most clinical chemotherapeutics. …
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Design and synthesis of novel P. fulciparum GDH inhibitors for use as potential antimalarial agents
Malaria is a potentially fatal parasitic disease that is endemic in 109 countries and threatens over 2.4 billion people, representing 40% of the global population. While there has been a gradual decrease in the number of fatalities resulting from the disease in recent decades, this progress is now …
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Antileishmania Compounds From An Unidentified Endophytic Fungus And Biotransformation Of 5,7,2`,4`,5`-Pentahydroxyflavonol
Leishmaniasis is a parasitic disease remaining a major public health problem. It causes illness and death especially in developing countries. Comchemotherapeutic agents currently used are often inadequate, requiring long courses of parenteral administration, having toxic side effects or becoming …
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Impact of Dietary Beta-glucan Supplementation on Performance and Immune Response of Broiler Chickens During Challenge
Coccidiosis is a costly parasitic disease to the poultry industry with multiple prevention methods being explored to control its impact. One approach under development is the use of -glucans, which are carbohydrates from cell walls of various plant species. The first study evaluated the feeding …
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Towards the development of an RT-PCR protocol for malaria parasite genes
Malaria is a life-threatening parasitic disease, which is becoming increasingly problematic in Sub-Saharan Africa due to the spread of drug-resistant parasite strains. Novel therapeutic targets and drugs are thus required to successfully treat and/or prevent malaria. The aim of this study was the …
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Estudo de modelagem molecular de derivados de desoxiuridina como inibidores da dUTPase de Plasmodium falciparum.
Malaria is a parasitic disease that continues to b e responsible for a huge number of deaths around the world. The disease is p resent in 99 countries with the alarming number of deaths per year reaching 655,000 ; about 3.3 billion people are at risk areas. Among the agents that cause malaria, …
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The relevance of red blood cell deformability in the pathophysiology of blood disorders
… blood transfusion. Malaria is the most deadly parasitic disease affecting hundred millions of people worldwide. Infected RBCs are found to be less deformable and therefore more susceptible to splenic RBC clearance. In this thesis, we identified several clinically used anti-malarial drugs that …
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A schistosomiasis health education intervention among rural Malawian school children : lessons learned
… the prevalence of schistosomiasis (Bilharzia), a parasitic disease, among school children in a rural area of11angochi District, Malawi between 1996 and 1998. The question this thesis addresses as its focus is, which degree of health education input is the most efficient in controlling …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
… with current drug treatments for this resurgent parasitic disease. Delivery of drugs into cells is an important determinant of therapeutic efficacy of drugs. An effective means of selective drug delivery is to use plasma membrane transport systems to mediate the entry of drugs into the cell. Some …
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Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle
Parasitic disease causes major health problems in humans and animals globally. Diseases in tropical and remote areas, sometimes known as neglected tropical diseases, pose some of the greater problems due to the difficulty in collecting and analysing samples. Collecting samples from remote and …
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Part A: Antimalarial agents modified at the C-16 position of artemisinin; Part B: Lead optimization of falcipain-2 and falcipain-3 inhibitors
… Malaria is a widespread tropical and subtropical parasitic disease which is caused by malarial parasites and transmitted by the infected anopheles mosquitoe. The natural product artemisinin and its derivatives are currently considered the most effective drugs against drug resistant plasmodium …
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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs
… world, tropical and subtropical regions. It is a parasitic disease spread through the bite of an infected Anopheles mosquito. In humans, malaria can be caused by several Plasmodium species that include: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae and Plasmodium …
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Mobile genetic element contribution to the genome architecture of the human parasitic flatworm Schistosoma mansoni
Schistosomiasis is a parasitic disease that affects approximately 250 million individuals worldwide, resulting in an estimated loss of more than 20 million disability-adjusted life years. Around 700 million people, predominantly in developing countries, live in at-risk areas. Schistosomiasis is …
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An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
… is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk in sub-Saharan Africa and up to 50,000 deaths per year caused by trypanosomiasis. Current …
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Inhibitors of human cathepsin L and cruzain as therapeutic agents.
… derivatives as potential inhibitors of this parasitic cysteine protease. Cruzain is the major cysteine protease of Trypanosoma cruzi organism and is a validated therapeutic target for the development of new chemotherapy. Chagas disease, a result of Trypanosoma cruzi infection, is the third …
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Cyst morphology and serological variation in cystic echinococcosis patients from Turkana, Kenya
Cystic echinococcosis (CE) is parasitic disease caused by cestode E. granulosus. Turkana in Northern Kenya carries one of the highest CE burdens in the world. Between 1983 and 2015 a control programme implemented there by African Medical Research Foundation (AMREF) using ultrasound screening for …
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Heterologous overexpression, purification, and characteristion of the Plasmodium falciparum vacuolar iron transporter, PfVIT
Malaria is a serious parasitic disease, caused by unicellular protozoa of the genus Plasmodium, which is responsible for high morbidity and mortality rates among those infected. Only in 2013, 198 million clinical cases of malaria infection and more than 0.5 million deaths were …
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