Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"parasite resistance"”.
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The Utilization of the Hmg2 Inducible Promoter to Genetically Engineer Parasite Resistance in Tobacco
… Orobanche aegyptiaca Pers., are obligate root parasites that cause severe yield and quality loss of many important crop hosts. Although these represent two diverse classes of parasites, they have significant similarities in the modes of parasitism and complex interactions with their hosts. …
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The effects of extended-release eprinomectin on heifer performance and fescue toxicity and an evaluation of parasite resistance
… are commonly used by livestock producers. Parasite resistance has been reported in ruminants in multiple macrocyclic lactones, after their use over time. As new versions of anthelmintics are released to the market, evaluations for resistance need to be conducted. In addition, the use of …
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Evolution of major histocompatibility complex genes in New World bats and their functional importance in parasite resistance and life-history decisions in the lesser bulldog bat (Noctilio albiventris)
… immune system and play an essential role in parasite resistance and associated life-history strategies. In addition to pathogen-mediated selection also sexual selection mechanisms have been identified as the main drivers of the typically-observed high levels of polymorphism in functionally …
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Characterizing physiological and genetic differences in the early immune response to Haemonchus contortus in resistant and susceptible sheep
… of immunological events resulting in parasite resistance in St. Croix hair sheep may provide better targets for differential gene expression analysis and eventual discovery of selectable markers for parasite resistance. Antibody levels of hair ewes and composite Dorset x …
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Differential gene expression and immune regulatory mechanisms in parasite-resistant hair and susceptible wool sheep infected with the parasitic nematode, Haemonchus contortus
… wool breeds to this blood-feeding, abomasal parasite. Our objective was to determine differences in the immune response associated with parasite-resistant hair and susceptible wool lambs infected with 10,000 H. contortus and in uninfected controls. Animals were sacrificed and abomasum and …
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Evaluation of terminal sire breeds for hair sheep production systems
… improve growth performance while maintaining parasite resistance have the potential to enhance the profitability of hair sheep enterprises. Katahdin (KT, n = 4), Suffolk (SU, n = 3), and Texel (TX, n = 3) rams were randomly mated to KT ewes over two years (Y1, Y2) at the Virginia Tech …
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Prothonotary Warbler (Protonotaria citrea) Plumage as an Indicator for Infection: the Relationship between Haemosporidia Infection and Breast Feather Reflectance in a Neotropical Migrant Passerine
… may act as an indicator for individual health, parasite resistance, and status. This study describes breast feather reflectance of adult Prothonotary Warblers (Protonotaria citrea) (n=169), insectivorous Neotropical migrant passerines, throughout the Ultraviolet (UV) and human visible light …
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Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype
The blood stage of the malarial parasite life-cycle is a vital stage that is believed to be a target for most antimalarial drugs. It is in this stage that host haemoglobin is degraded to provide nutrients for the survival of the parasite. However, a pathway (known as the haem detoxification …
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Genomic selection studies in sheep using simulation and real data
… data on genotype-by-environment interactions for parasite resistance in U.S. Katahdin sheep. The first study summarizes the status of genetic improvement in Turkey, one of the world's largest sheep producers. Akkaraman and Morkaraman are two local breeds that have adapted well to harsh …
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Genetically Modifying Mosquitoes Without Compromising Fitness: Can It Be Done?
Malaria is a mosquito-borne disease caused by parasites belonging to the genus Plasmodium. Malaria remains one of the most devastating infectious diseases, killing nearly half a million people each year (WHO 2015). 1,2 With the current increase in drug and insecticide resistance, there is an urgent …
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Structure-activity and structure-property relationships of antimalarial pyrimido[1,2-a]benzimidazoles, imidazo[1,2-a]pyridines, and imidazo[1,2-a]pyrimidines
… age of 5 years. Due to the widespread rise of parasite resistance, current treatments may no longer be effective. Furthermore, artemisinin-based combination treatments (ACTs), which are the first-line antimalarial medications currently recommended by the World Health Organization (WHO), are …
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AVALIAÇÃO DA ATIVIDADE ANTILEISHMANIA DA PLA2 Lys49 MjTX-I, ISOLADA DA PEÇONHA DE Bothrops moojeni
… treatment presents high toxicity, high cost, parasite resistance and difficulties in cure. In this sense, snake venoms are a promising source of study, since they have a series of bioactive compounds with therapeutic potential, among these, phospholipases A2 (PLA2) stand out. Thus, the …
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Dendritic cell regulation of immunity to Leishmania donovani
… donovani is an intracellular protozoan parasite of mammalian phagocytes, capable of establishing a persistent and life-threatening infection in man. Associated with profound immunopathology and chronic immune suppression, visceral leishmaniasis is endemic to some of the world’s most …
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Small molecules with anti-trypanosomal and anti-leishmanial activity
… largely based on those that are already in use. Parasite resistance to these drugs is developing, underlining the urgent need for novel anti-parasitic drug therapies. This study focused on the identification of novel small molecular inhibitors with anti-parasitic activities against Trypanosoma …
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Estudo de modelagem molecular de derivados de desoxiuridina como inibidores da dUTPase de Plasmodium falciparum.
… due to its indiscriminat e use for years, parasite resistance to these treatments has become a big pro blem. The enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) of Plasm odium falciparum (EC 3.6.1.23) was chosen as the molecular target for th is study. We produced a complete …
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MHC Class I diversity influences haematozoon infection intensity in the polymorphic black sparrowhawk (Accipiter melanoleucus)
… between MHC class I diversity and blood parasite infection intensity is explored in a population of black sparrowhawks (Accipiter melanoleucus). The species is of particular ecological and evolutionary interest as black sparrowhawks display a discrete polymorphism in plumage pattern …
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Age End-Point Effects on Performance, Carcass Measurements, and Tenderness in Goats
… of birth, and previous treatments (high vs. low parasite resistance) and assigned randomly to slaughter age end-points (135, 180, 225, 270, 315, 360, 405, or 450 d of age). At slaughter, animals were transported 450 km (4.5 h) from Lincoln University’s Carver Farm to the University of Arkansas …
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Coping with Chronic Infection: The Role of Glucocorticoid Hormones in Mediating Resistance and Tolerance to Parasites
… to individual differences in the use of two parasite defense strategies, resistance and tolerance. Resistance entails reducing parasite burden by removing parasites or restricting parasite reproduction. Tolerance involves minimizing the costs associated with a given parasite burden. Genetic …
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Pharmacological effect of MEK inhibitors on plasmodium falciparum
… to kill up to 3 million people each year, and parasite resistance to drugs is a pressing problem. Protein kinases are now prime targets for chemotherapy in a variety of diseases such as cancer and neurodegenerative diseases, and have been proposed as potential targets for antimalarial …
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