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Showing 1 to 3 of 3 for “"paraneoplastic cerebellar degeneration (PCD)"”.
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Characterization of the Paraneoplastic Cerebellar Degeneration Antigen Cdr2
<p>Paraneoplastic cerebellar degeneration (PCD) is a remote effect of breast and ovarian cancer on the nervous system. It is believed to arise when these tumors ectopically express a neuron-specific protein, thereby initiating an anti-tumor immune response that subsequently develops into a neuronal …
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From Naturally Occurring Tumor Immunity to Supernatural T Cells: Isolation and Characterization of a Murine T Cell Receptor Specific for Human Breast and Ovarian Tumor Antigen Cdr2
<p>Patients with paraneoplastic cerebellar degeneration (PCD), a form of neuronal autoimmunity, have a co-occurring natural immune response against a protein called cdr2 in their breast and ovarian carcinomas, and thus provide an innovative starting point for understanding how to harness the immune …
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The Hu Syndrome: At the Intersection of Cancer and Autoimmunity
<p>Paraneoplastic neurologic diseases (PNDs) arise when systemic malignancies express proteins normally restricted to neurons. Abnormal expression of a neuronal protein by tumor cells in the periphery results in an autoimmune response that then targets both the tumor and the nervous system. These …