Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"paralogue"”.
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Using sequence data to investigate the functional design of proteins
… which determine the specificity of protein paralogues that have diverged in function. I will show that this can be achieved by investigating evolutionary sequence variation using a probabilistic framework. The new approach to examine the importance of each amino acid in the protein primary …
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Elucidating the functions of RNA helicases DDX3X and DDX3Y in normal and malignant B cells
… as a regulator for translation. Its Y chromosome paralogue, DDX3Y shares 92% amino acid conservation. DDX3X is ubiquitously expressed and considered pan essential. While DDX3Y is widely transcribed, its protein expression is predominantly limited to spermatogonia cells or at least restricted to …
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Characterisation of HP1γ in mammalian cells
… consists of three members: HP1α, β and γ. Each paralogue regulates formation and maintenance of heterochromatin by binding to the repressive chromatin marks H3K9me2/3 with their chromodomains (CDs). Despite high sequence conservation, each HP1 paralogue possesses specific functions, which are …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… the interaction of P48 with either RBP-J, or its paralogue, RBP-L. The exclusive form of PTF1 in mature pancreatic acinar cells is a potent transcriptional activator containing RBP-L; however, RBP-J can form a similar, but low activity, complex. The P48-RBP interaction is primarily through two …
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Regulation of Myo5p function by phosphorylation
… results support a model in which Pkh2p and its paralogue Pkh1p are part of a signalling cascade that leads to TEDS site phosphorylation and thus myosin-I activation for endocytosis. A second important feature of fungal myosins-I is their ability to induce actin polymerization through the Arp2/3 …
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EZH1 variants disrupt neurogenesis in hPSC-derived neuronal models and cause neurodevelopmental disorders
… of the Polycomb Repressive Complex 2 (PRC2). Its paralogue, EZH2, is essential in maintaining transcriptional repression of non-lineage specific genes during development. In neurodevelopment, EZH2 is highly expressed in dividing cells, and its dysfunction leads to defects in neural progenitor …
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Investigation of the immunological differences between granulocytes from healthy donors and breast cancer patients, with respect to the cancer testis antigen, CTCFL
… Of the Regulator of the Imprinting Site) is a paralogue protein to a ubiquitously expressed transcription factor, CTCF. The expression of CTCFL was detected exclusively in the spermatocytes. The role of BORIS was then supposed to be linked to the de novo DNA-methylation and re-establishment of …
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THE EVOLUTION OF BEETLE BIOLUMINESCENCE
… coleopteran SGL clades with species-specific paralogues present in both clades, which suggests early duplication in the Coleoptera and potential functional divergence of SGL enzymes. The highest degree of divergence was found between a subclade of group I (la) containing all the lampyrid LREs …
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Role of the MecA adaptor protein in regulation of the AAA + chaperone ClpC of Bacillus subtilis
… In addition it was demonstrated that the MecA paralogue YpbH, which is not involved in the regulatory proteolysis in B. subtilis, displayed comparable chaperone activities. Therefore MecA and YpbH may have a general and complementary function in protein quality control. These and other …
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Elucidating the role of TM9SF2 in membrane trafficking
… with TM9SF2. Furthermore, as QSOX1, a paralogue of QSOX2, plays a role in regulating the activity of Golgi enzymes, this may suggest an alternative mechanism for TM9SF2 in the regulation of glycosyltransferases, by regulating 4 disulphide bond formation. Our results provide greater …
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Mitochondrial Dysfunction and Stress Responses in CHCHD10 Myopathy and Neurodegeneration
… in the mitochondrial protein CHCHD10 and its paralogue CHCHD2 were shown to cause familial amyotrophic lateral sclerosis and Parkinson’s disease, respectively, with phenotypes that often resemble the idiopathic forms of the diseases. Different mutations in CHCHD10 cause additional …
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The role of <em>Pax7</em> in the formation of the superior colliculus and the vertebrate visual system
… subsequently superior collicular polarity. The paralogue Pax3 is thought responsible for sustaining embryonic development in Pax7 mutant mice, resulting in a less severe phenotype. Therefore, this project explored temporospatial patterns of Pax3 expression relative to Pax7 expression during all …
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… coactivators. The p300 protein and its close paralogue CREB-binding protein (CREBBP, aka CBP) are well-known transcriptional coactivators that have intrinsic lysine acetyltransferase activity. The functions of p300/CBP largely rely on their capabilities to bind to chromatin and to acetylate …
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Analysis of the functions and interactions of RAD51 paralogues in Trypanosoma brucei
… distantly related to RAD51; termed RAD51 paralogues, named RAD51-3, RAD51-4, RAD51-5 and RAD51-6. Two of these RAD51 paralogues, RAD51-3 and RAD51-5, have been shown to function in homologous recombination, DNA repair and RAD51 re-localization into foci following DNA damage. Surprisingly, …
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Expanding the Role of Oxidoreductases in Benzylisoquinoline Alkaloid Metabolism in Opium Poppy
… sequence as a query, we identified a COR paralogue from an opium poppy transcriptome database that was fused and in frame with a CYP. The resulting protein fusion catalyzed the S-to-R epimerization of reticuline via 1,2-dehydroreticuline. The fusion protein, renamed reticuline epimerase …
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Stress-signal recognition in the unfolded protein response
… regulatory mechanisms acting on the two IRE1 paralogues IRE1α and IRE1β to understand their unique physiological function and infer general principles of UPR regulation. For IRE1α, it has been proposed that the Hsp70 chaperone BiP, a major component of the ER protein folding machinery, couples …
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Regulation of human protein kinases and phosphatases by 14-3-3
… protein FAM122A and its paralogue FAM122C form stable stoichiometric complexes with the protein phosphatase 2A (PP2A) heterotrimer (AαB55αC). Moreover, the FAM122A–PP2A complex is active and contains methylated catalytic C subunit. In contrast, a complex comprising the …
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A Practice-Led Inquiry into Collaboration with Landscape within the Expanded Field of Photography
… plate. Tangential to all these plates, the Paralogue, acts as a legend to the rhizomic map in the sense of an extended glossary and context. This practice-led inquiry reveals that collaboration with a non-human agency is not reducible to a single approach, but rather, it is an entangled …
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Application and Development of Advanced Genetic Tools to Study Adult Stem Cells
… remain poorly understood. Rnf43 and its paralogue Znrf3 (RZ) act as tumour suppressors in the intestine, but their role in the gastric epithelium has not been previously investigated. Using a novel unpublished stomach specific CreERT2 expressing mouse line I found that simultaneous …
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Early land plant origins of the MYB-bHLH-WDR complex
A major aim in the field of evolutionary developmental biology (evo-devo) is to identify the mechanisms by which developmental novelties arise. The observation that incited the present study was the identification of a common theme across the differentiation of multiple specialised cell types in …
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