Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"paralogs"”.
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Interactions of human and drosophila Rad 51 paralogs
… of a subset of these proteins known as the Rad51 paralogs.</p> <p>The goal of this study is to determine if the putative Rad51 paralogs in Drosophila melanogaster are sufficiently conserved as to function in the same manner as their human counterparts. This research is part of a larger project to …
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Investigating the effect of paralogs on microarray gene-set analysis
… genes are expressed independently. We show that paralogs, which typically have high sequence identity and similar molecular functions also exhibit high correlation in their expression patterns. This, together with the fact that the calculation of gene-set significance by all GSA methods is …
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Expanding cancer therapy options through genome-scale identification of synthetic lethal paralogs
… mapping (pgPEN). pgPEN targets over 2,000 human paralogs, or duplicated genes. We applied pgPEN to lung and cervical cancer cell lines and found that 12% (n = 122) of paralog pairs exhibited synthetic lethality in at least one context. These synthetic lethal paralogs represent new potential …
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A functional study of the<em> Phytophthora infestans</em> Avr3a alleles and paralogs
… of this thesis, which also include the Avr3a paralogs Pex147-2 and Pex147-3. <br/><br/>By examining the amino acid changes in relation to the established protein structure, it was determined that all alterations within the Avr3a variants occur at surface exposed amino acids. The change R124G …
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Role of subfunctionalized MYB paralogs in the evolution of pigmentation patterning in Clarkia
… pigments, always involves subfunctionalized MYB paralogs that each control the initiation of pigmentation in a specific pattern element. These early studies have mostly focused on the mechanism for patterning, though, and few have looked at the evolution and diversification of this complex …
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Insights into the rice and Arabidopsis genomes: intron fates, paralogs, and lineage-specific genes
<p>With the availability of near-complete rice genome sequence,</p> <p>high-quality annotation data, and large expression profile datasets, we examined</p> <p>segmental duplication, intron turnover, and paralogous protein family</p> <p>composition in rice. These data suggest a large percentage of …
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Dissecting the regulatory roles and cellular functions of mammalian ZSCAN5B and primate-specific paralogs
… founding member, ZSCAN5B, and clustered paralogs that arose early in primate history, and this clustered subfamily has been the subject of my thesis work. I have shown that three of the primate paralogs, ZSCAN5A, B, and D, are expressed in different tissues and cell types while ZSCAN5C is …
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The behavior of RAD51D and XRCC2 in response to drug induced DNA damage and a continuing study of the fly RAD51 paralogs
… of this experiment followed two Drosophila Rad51 paralogs, dmRad51D and dmXRRC2, and using constructs tagged with GFP, found that they entered the nucleus in response to drug induced DNA damage. Approximately one hour after the induction of DNA damage via bleomycin, dmRad51D and dmXRCC2 entered …
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The Role of TNRC6 in RNA Interference
… in many different processes. There are three paralogs in mammalian cells, TNRC6A, TNRC6B, and TNRC6C. These paralogs share approximately 40% amino acid sequence identity. Whether the paralogs have unique or redundant functions is unclear. Much is known about the mechanisms of cytoplasmic RNAi …
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The Evolution of the Deubiquitinating Enzyme Superfamily
… within molecular systems as gene duplicates (paralogs) and alternatively spliced isoforms. Proteins related in this manner often serve redundant roles, though they can be selectively or randomly prescribed unique functions. The present collection of three manuscripts details the evolution of …
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INVESTIGATION OF THE NOVEL ANTITERMINATION MECHANISM OF LOAP, A NUSG SPECIALIZED PARALOG
… operons, and CRISPR arrays. Specialized NusG paralogs, such as LoaP, RfaH, or UpxY, are widespread in bacteria and likely form their own unique antitermination complexes. RfaH, the only well-studied paralog, binds to a paused TEC via a specific non-template DNA sequence, then prevents Rho …
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DROSOPHILA CLASS-I MYOSINS THAT CAN IMPACT LEFT-RIGHT ASYMMETRY HAVE DISTINCT ATPASE KINETICS
… the molecular mechanisms of two class-I myosin paralogs, myosin-1C (myo1C) and myosin-1D (myo1D), that can impact Drosophila Left-Right asymmetry. De novo overexpression of either paralog in symmetric tissues results in opposing tissue rotation, dependent on the paralog. De novo overexpression …
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Homeobox gene and microRNA duplication in Chelicerata
… Furthermore, the expression patterns of homeobox paralogs have diverged during embryogenesis and may represent cases of sub- and neo-functionalisation. Additionally, the mir-3791 family in P. tepidariorum has expanded due to the proposed WGD and further tandem duplications. This family has …
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Subunit Compositions of Arabidopsis DNA-Dependent RNA Polymerases and the Roles of the Plant-Specific RNA Polymerases IV and V in Gene Silencing
… of Pol IV are distinct from their Pol II paralogs, six subunits of Pol V are distinct from their Pol II paralogs, and four subunits differ between Pol IV and Pol V. Importantly, the subunit differences occur in key positions relative to the template entry and RNA exit paths. My findings …
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Incomplete paralog compensation and splicing regulation by TRA2A and TRA2B in cancer
… synthetic lethality, where co-disruption of both paralogs results in cell death. This dissertation explores the functional relationship between the splicing factor paralogs TRA2A and TRA2B, members of the serine/arginine-rich (SR) protein family. In a subset of cancer cell lines, TRA2A emerges as …
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Quantitative modeling of 5' splice site subclass regulation and evolution
… 5→ SS in exons affected by the three human LUC7 paralogs: LUC7L2 and LUC7L enhance splicing of “right-handed” 5→ SS that exhibit stronger consensus matching on the intron side of the nearly-invariant / GU, while LUC7L3 boosts splicing of “left-handed” 5→ SS with stronger consensus matching …
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Flowering Gene Homologs Regulate Seasonal Growth Changes in Poplar
… complete functional equivalency. Among the three paralogs, only FDL2.2 promoted precocious flowering, whereas FDL1 and FDL3 appear to have distinct roles in vegetative growth and phenology. Whereas overexpression of any FDL gene delays short day-induced growth cessation and bud set, only FDL3 …
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Engineering orthogonal signaling pathways to probe sequence space capacity
… become insulated from each other, and from other paralogs, to prevent unwanted cross-talk. A similar challenge arises when new sensors or synthetic signaling pathways are engineered within cells or transferred between genomes. How easily new pathways can be introduced into cells depends on the …
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Nucleoid-Associated Proteins of Streptomyces coelicolor: Discovery and Functions
… The mutant phenotypes of both S. coelicolor paralogs of HU (HupA and HupS) were examined and showed opposite effects on growth, spore formation and actinorhodin production. The mutant phenotypes of both S. coelicolor paralogs of the H-NS-like proteins Lsr2 (SCO3375 and SCO4076) were milder …
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Evolution of the Proteasome
… cerevisiae DNA, which encodes seven paralogs. Although several novel gene fragments were found, the method was insufficient to determine the precise number of paralogs in the eukaryotic genomes tested. Next, publicly available full genome sequences were mined to perform phylogenomic …
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