Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"paracrine signaling"”.
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
… understood. To study microenvironment signaling and its impact on therapy response, I have used mouse models of B-cell leukemia and lymphoma. I find that the chemotherapeutic doxorubicin promotes endothelial IL-6 release through reactive oxygen species-mediated p38 signaling and use …
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Engineering polymer biomaterial interfaces for promoting cellular morphogenesis
… and nutrient exchange, as well as facilitating paracrine signaling with surrounding epithelial cells. Fully-defined and tunable synthetic ECMs that support the generation of vascular network structures in dense tissue environments represent a path towards overcoming the limitations of existing …
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Quantitative studies of EGFR autocrine induced cell signaling and migration
… growth factor (EGF) receptor autocrine and/or paracrine signaling plays an important role in normal epithelial cell proliferation, survival, adhesion and migration. Aberrant expression of the EGF receptor and its cognate ligands have been implicated in various types of cancers, hence EGF …
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… tightness of the BBB, and the juxtacrine and paracrine signaling events occurring between brain endothelial cells and stromal cells during vasculogenesis. To integrate these features into a physiologically relevant blood-brain barrier model, we designed an in vitro microvascular network …
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Engineered Liver and Intestine Platforms for Modeling Physiology and Disease
… non-pregnant as a control) to elucidate how paracrine signaling contributes to dramatic changes in liver functions during pregnancy; translation of these findings to human hepatocytes is also explored. In conclusion, engineered models of the intestine and liver are useful for modeling changes …
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Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle
… activity stimulate vascular wall angiotensin signaling, resulting in smooth muscle contraction which directly increases peripheral resistance. Calcium influx through voltage-gated L-type calcium channels underlies vascular smooth muscle contraction. Roughly half of calcium influx in these …
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GATA Like Protein-1: A Somatic Cell Factor Required for Normal Ovarian Development and Function
… and precisely timed communication through paracrine and endocrine signals of neighboring tissues. Deviations in the cross talk between ovarian cells, or aberrant gene expression within one of the cell populations, can lead to germ cell loss and infertility in the adult female. Expression of …
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Cardiac organoid technology and computational processing of cardiac physiology for advanced drug screening applications
… endoderm tissue, which is seen in vivo through paracrine signaling between the liver and heart. We then implemented computational tools based on nonlinear mathematical analysis to evaluate the cardiac physiological drug response of stem cell-derived cardiomyocytes. This dissertation discusses in …
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The role of prostate cancer microvesicles in epithelial mesenchymal transition
… and transcriptional factors, which can mediate paracrine signaling in the tumor microenvironment, and that they are thus highly capable of altering the function of the recipient cells. MVs released from tumour cells are thought to play an important role in cancer metastasis. Most carcinomas are …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… of a local antiviral state through autocrine and paracrine signaling. However, despite these protective measures, IAV continues to cause significant annual morbidity and mortality across the globe. Therefore, we sought to further investigate how specific mucin molecules interact with IAV, and how …
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HOW MICROVESICLES ARE "BUDDING" INTO THE CANCER CONVERSATION: THE ROLE OF GLYCOCALYX-INDUCED MEMBRANE BENDING
… by direct cell-to-cell contact as well as local paracrine signaling between cancer and normal cells. However, tumor-derived extracellular vesicles (EVs), which are lipid bilayer vesicles released from cancer cells, can travel long distances in the body and cytosolically deliver oncogenic cargos, …
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Dissecting mechanisms and consequences of oncogenic RTK fusion signaling
… broader implications of their activity for cell signaling and how these largely cytoplasmic proteins activate downstream pathways that originate at the plasma membrane. Here, we use optogenetics and live-cell imaging to find that EML4-ALK, an oncogenic fusion present in 5-7% of non-small cell …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… both of which participate in autocrine and paracrine signaling that perpetuates pancreatitis.
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Engineering the tumor microenvironment using microfluidics : effects of cell-cell interactions and endothelial barrier function on tumor cell intravasation
… low expression of basement membrane proteins and signaling with macrophages. Under all these conditions, tumor cell intravasation rates increased and we confirmed these results for multiple tumor cell types. Characterization of macrophage secreted factors and M1/M2 polarization status, identified …
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A three-dimensional in vitro tumor model representative of the in vivo tumor microenvironment
… "bioengineered tumors." It was hypothesized that paracrine signaling between tumor and endothelial cells co-cultured within this system would be sufficient for inducing an angiogenic response in the absence of exogenous pro-angiogenic growth factors. Endothelial cells in the co-culture group were …
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Mechanisms of Calcium Wave Initiation and Propagation in Astrocytes
… plasticity. Not surprisingly, aberrant Ca signaling is thought to play a featured role in the pathophysiologies associated with dysfunction of these processes. This suggests that elucidation of the mechanism of Ca<sup>2+</sup> waves will lead to rational therapeutic modalities for a variety …
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Nutrient Sensing in Immune Function: A Systems Biology Approach
… proteins or metabolites, through putative paracrine signaling, confer these effects on innate and adaptive immune cell functioning. We hypothesize that circulating metabolites play a pivotal role in regulating nutrient-dependent immune function. To identify these metabolites and elucidate …
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New Therapeutic Strategies for Amyotrophic Lateral Sclerosis Treatment
… beneficial effects on host neural cells through paracrine signaling for extended period of time. Our findings strongly suggest potential benefits of neural induction of MSCs to develop successful stem cell therapy for the treatment of ALS. Glial cell line-derived neurotrophic factor (GDNF), which …
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Mechanical modulation of indirect repair mechanisms for improved hematopoietic recovery
… vivo. VEC-mediated angiogenesis and angiocrine signaling are known to support hematopoietic recovery in vivo. In this thesis, we first explored how the biophysical cue of macromolecular crowding (MMC) and the mechanical cue of strain can regulate angiogenesis. The addition of synthetic MMC to in …
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