Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"papillary thyroid carcinoma"”.
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Differentiating follicular thyroid carcinoma from the follicular variant of papillary thyroid carcinoma
… follicular adenoma (FA), follicular thyroid carcinoma (FTC) and follicular variant of papillary thyroid carcinoma (FVPTC) remain a diagnostic challenge in some cases. This is as a result of the assessment of nuclear features being highly subjective, and the threshold for confirming …
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Risk of cervical lymph node metastasis in papillary thyroid carcinoma: Correlations with lymphangiogenesis and ultrasound features
… for cervical lymph node metastasis (LNM) in thyroid papillary carcinoma is important for providing standards for post-operative adjuvant radio-iodine therapy and for predicting patient prognosis. We investigated pathological factors based on the lymphatic vessel system and ultrasound features …
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FROM NUCLEUS TO MITOCHONDRIA: INSIGHTS INTO THE ROLE OF TERT IN THE PROGRESSION OF PAPILLARY THYROID CARCINOMA
… and therapy-induced oxidative stress (OS). Papillary thyroid cancers (PTCs) have a generally good prognosis but a small subset of cases can dedifferentiate and become more resistant to radioiodine used as a first-line treatment in cases of metastatic PTCs, a trait often found in TERT …
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Mechanistic Study of Fragile Site Breakage by Investigating RET/PTC Rearrangements, a Common Cause of Papillary Thyroid Carcinoma
Chromosomal fragile sites are non-random regions of the genome with a predisposition to the formation of DNA breaks. Common fragile sites, which are found in all individuals, often coincide with regions mutated in cancer, and therefore are believed to play a role in carcinogenesis. However, there …
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LOTS OF AWFUL THINGS: INTERSECTIONS OF QUEERNESS AND CANCER THROUGH AUTOETHNOGRAPHY
… between my experiences through the treatment of papillary thyroid carcinoma and crip-queer theory. This dissertation seeks to bridge queer theory, disability studies, and medical discourse through personal experience. Additionally, by employing autoethnography, this study creates nuanced …
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DNA FRAGILE SITE BREAKAGE AS A MEASURE OF CHEMICAL EXPOSURE AND PREDICTOR OF THE SUSCEPTIBILITY TO FORM CHROMOSOMAL REARRANGEMENTS
… we focused on RET/PTC rearrangements in papillary thyroid carcinoma. All genes participating in the two most common types of RET/PTC rearrangements, RET/PTC1 and RET/PTC3, are located within common fragile sites. Fragile sites are sensitive to a variety of environmental chemicals and …
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From genotype to phenotype: novel methodologies for the discovery of new pathological biomarkers in human
… analysis techniques related to microRNAs in Papillary Thyroid Carcinoma and to long non-coding RNAs in Diffuse Large B-cell Lymphoma. Chapter 3 explains the debated competing endogenous RNA mechanism of post-transcriptional regulation and presents CERNIA, a machine learning framework for …
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Skydliaukės vėžio gydymas lazerine abliacija: galimybių tyrimas /
… effect of laser ablation in patients with papillary thyroid carcinoma. Subjects and methods. Adult patients with a thyroid node up to 4 cm, cytologically suspected or confirmed thyroid carcinoma (Bethesda V-VI), and evidence of thyroid node malignancy on ultrasound examination (EU-TIRADS …
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
… constitutively active forms of RET can lead to thyroid neoplasia. Missense mutations are causative agents in multiple endocrine neoplasia type 2 (MEN 2), featuring medullary thyroid carcinoma (MTC), whereas RET fusion oncoproteins generated by gene rearrangements are associated with papillary …
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Optimization of BRAF V600 Assay as A 2-Step Real-time PCR Protocol
… lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even prostate cancer. Currently, the established qPCR protocol for the QClamp® BRAF Mutation Detection Assay is comprised of a 4-step procedure: <em>Denaturation, XNA …
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Investigation of microRNA expression in thyroid carcinoma among South Africa patients
Objective: Thyroid cancer affects approximately 298 million people worldwide and the major challenge is reliably distinguishing patients who present with poor prognosis from those who do not. There are genetic markers that have been shown to be associated with poor clinical outcome in thyroid …
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Expression of X-linked Inhibitor of Apoptosis Protein in Neoplastic Thyroid Disorder
… patterns of XIAP in various neoplastic thyroid disorders and determine the association between XIAP expression and clinicopathologic factors. We additionally evaluated the association of XIAP expression and the BRAFV600E mutation and analyzed the association of XIAP expression and tumor …
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RET Mediated Gene Expression and Cell-Migration
… RET mutations are associated with several thyroid cancers. Papillary thyroid carcinoma is frequently associated with sporadic translocations between RET and other genes, known collectively as RET/PTC. A variety of heritable RET missense mutations lead to Multiple Endocrine Neoplasia type 2, …
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Genomic Characterization of Adolescent and Young Adult Cancers: Investigation of Ewing Sarcoma Susceptibility and Chornobyl Thyroid Tumors
… AYA cancer types: Ewing Sarcoma (EwS) and papillary thyroid carcinoma (PTC). In the EwS study, we describe the interplay between a somatic driver, EWSR1- FLI1, and a highly polymorphic GGAA microsatellite in the 6p25.1 EwS GWAS susceptibility locus, employing third generation long-read …
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Variation-aware algorithms for cancer genome analysis
… where radionuclides were deposited developed thyroid cancer. The excess relative risk of thyroid cancer has been estimated to be between fifteen and thirty fold higher following $^{131}I$ exposure. In Chapter 2, I analyze more than 300 thyroid cancer cases from children and young adults …