Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"pancreatic development"”.
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The Adar-Mavs Pathway Is A Critical Mediator of The Innate Immune System In Pancreatic Development and Cancer
… aberrations in Adar expression are implicated in developmental deformities and carcinogenesis. The work presented in this thesis explores the yet undefined role of Adar in pancreatic development and tumor biology. Through genetic mouse models, we conclusively show that the primary function of Adar …
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From Bud to Organ: An In Depth Analysis of the Development of the Pancreas.
… a careful analysis of different aspects of pancreatic development was conducted in order to expand our understating of the biology of this organ. This thesis encompasses an in depth description of pancreas macro morphology throughout development as well as the analysis of the role of …
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BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality
Pancreatic development begins in the mouse, at embryonic day 8.5, as two patches within the gut tube that are located between the stomach and the duodenum. These patches begin to bud, proliferate, and differentiate to become the dorsal and ventral pancreas. During pancreatic bud development several …
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The role of transcription factor GATA6 in the development of the human pancreas
… been in mice. The paucity of research in the development of the human pancreas has led to diminished knowledge in the area, compared to other species. Recent discoveries provide growing evidence for discrepancies between mouse and human pancreatic development and diseases and highlight the …
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Primate-specific KRAB zinc finger proteins and their targets rewire regulatory networks related to inflammation and pancreas development
… homozygous knock out in patients diagnosed with pancreatic agenesis, presenting neonatal diabetes with insufficient pancreatic exocrine function. Expression and ChIP data for ZNF808 show that it is upregulated during the early stages of pancreatic development and binds on members of primate …
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Isolation and characterization of CEABF-1, the ABF-1 homolog in C. elegans
… transcription factors is important in many developmental and regulatory pathways such as cellular proliferation and differentiation, lineage commitment, sex determination, neurogenesis, myogenesis, hematopoeisis and pancreatic development. The free-living nematode Caenorhabdits elegans is an …
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Stem cell-based regenerative pharmacology for the treatment of diabetes mellitus
… are an attractive starting source for producing pancreatic lineage derivatives to be used in treatment of DM as a form of cell replacement therapy, immunotherapy and in attempts to model diabetic disease phenotypes in vitro for identification of novel drug targets. Amniotic fluid stem (AFS) cells …
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The endoplasmic reticulum chaperone ERdj4 is required for survival, glucose metabolism and B cell development
… gene trap neonates exhibited signs of delayed pancreatic development, including abnormal distribution of pancreatic α- and β-cells and reduced insulin and glucagon in the pancreas. Surviving adult ERdj4 gene trap mice were glucose intolerant, resulting from hypoinsulinemia rather than insulin …
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Encapsulation as a 3D model for human embryonic stem cell propagation and differentiation
… ontogenic approach which mimics the in vivo pancreatic development. This approach requires a three dimensional (3D) culture system that can induce cell-cell and cell-matrix interactions which are essential for functional maturation. This project investigated the use of cell encapsulation …