Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"pancreatic cell line"”.
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Studies on intracellular calcium pools in a pancreatic cell line
… (IP₃) can release Ca²⁺ from intracellular stores, the phosphatidylinositol signal transduction system has been recognized as a major transduction pathway in most cell types. However, IP₃ is not the only intracellular Ca²⁺ mediator. In some cells, guanosine 5'-triphosphate (GTP) and …
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Development of monoclonal antibodies for the identification of novel invasion associated targets in human cancer.
… against the highly invasive MiaPaCa-2 clone 3 pancreatic cell line, and the MDA-MB-435-SF breast cancer cell line. Two MAbs were identified that could successfully block cancer invasion in vitro. MAb 7B7 G5 (2) significantly reduced invasion in the MiaPaCa-2 clone 3 pancreatic cell line; the …
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Characterisation of RNA modifications in human cancer cells
… the enzymes that catalyse its deposition. Using pancreatic ductal adenocarcinoma cancer (PDAC) cells as a model system, I discovered that m1G methylation is present on mRNA where it is catalysed by TRMT5, an enzyme previously identified as a tRNA methyltransferase (TRMT). Utilising ribosome …
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Oncogene-induced reprogramming of heterotypic cellular interactions
… signalling hub that orchestrates fundamental cellular decisions such as cell survival, proliferation and differentiation. Activating mutations in KRAS are among the most frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., colorectal, …
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Photoactivatable Organic and Inorganic Nanoparticles in Cancer Therapeutics and Biosensing
… (ROS). These ROS react with biomolecules in cells leading to cell damage and cell death. PDT has interested many researchers because of its non-invasiveness as compared to surgery, it leaves little to no scars, it is time and cost effective, it has potential for targeted treatment, and can be …
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Investigation of insulin releasing and glucose lowering effects of extract of selected plants used in African traditional medicinal practice
… of insulin secretion and in the absence of extracellular calcium were also investigated. Cytotoxicity and effects of extracts on cell viability and cell proliferation were assessed in cells treated with the various plant extracts. Protein glycation and antioxidant properties of the extracts were …