Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"pancreatic adenocarcinoma"”.
-
Integrin alpha6beta4 contributions in pancreatic adenocarcinoma
Pancreatic adenocarcinomas are among the most lethal human cancers due to an elevated incidence of tumor cell invasion and metastasis for reasons that are currently unclear. In this dissertation, I determined how the pro-invasive integrin alpha6beta4 expression was related to pancreatic …
-
Liquid Chromatography – Mass Spectrometry for Protein Biomarker Discovery in Pancreatic Adenocarcinoma
Pancreatic cancer has one of the lowest survival rates of all cancers, partly due to the difficulty of detection in its early stages. Recent developments in liquid chromatography – mass spectrometry (LC-MS) technology have made it possible to profile proteins associated with disease in a …
-
Clinical Relevance of Immune Cells in Pancreatic Adenocarcinoma and their Implication in Immunotherapy
… focused on the immune microenvironment of pancreatic adenocarcinoma (PDAC). The aim was to delineate key features of immunologic and tumour components shaping the biology of pancreatic cancer. Immunotherapy has been largely explored as a promising anticancer approach but not convincingly …
-
Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
… a more physiological spontaneous murine model of pancreatic ductal adenocarcinoma (PDA). CD8+ T cells from PDA bearing mice show reactivity against thei.r own tumour cells in ELISpot assays, indicating an ongoing response to tumour antigens. Relieving immune suppression by depletion of FAP+ cells …
-
Development of a prognostic and predictive tool for chemotherapy response in patients with locally advanced and metastatic pancreatic adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most formidable challenges in modern oncology, marked by its asymptomatic progression, late diagnosis, limited therapeutic options, and dismal prognosis. In Spain, PDAC ranks as the eighth leading cause of cancer-related mortality, with the …
-
Synergistic Effects Of Garcinol And Gemcitabine In Enhancing Therapeutic Efficacy In Pancreatic Adenocarcinoma Cells And Its Effect On Microrna Profile
… GEMCITABINE IN ENHANCING THERAPEUTIC EFFICACY IN PANCREATIC ADENOCARCINOMA CELLS AND ITS EFFECT ON MICRORNA PROFILE</p> <p>By</p> <p>MANSI PARASRAMKA</p> <p>ADVISOR: DR. SMITI V. GUPTA</p> <p>MAJOR: NUTRITION AND FOOD SCIENCE</p> <p>DEGREE: DOCTOR OF PHILOSPHY</p> <p>Human Pancreatic Cancer (PaCa) …
-
Descriptive epidemiology and outcome of patients with intraductal papillary mucinous neoplasm (IPMN): a population-based comparison to pancreatic adenocarcinoma and review of literature.
… do better than patients with invasive IPMNs and adenocarcinoma, it is not clear if, once invasive, IPMNs have a more favorable prognosis than adenocarcinoma not associated with IPMNs. Our goal was to evaluate a large population-based cohort of patients with invasive IPMN and compare their …
-
Determining the Oncological and Immunological Effects of Histotripsy for Tumor Ablation
… and can withstand mechanical ablation, including pancreatic adenocarcinoma, osteosarcomas, and soft tissue sarcomas. Pigs share many similarities with human anatomy and physiology, making them an ideal model organism for testing new medical devices and regimes for treating new targets. Using pigs, …
-
Nanomaterials and Block Copolymers for Overcoming Multidrug Resistance in Cancer
… known chemosensitive and chemoresistant pancreatic adenocarcinoma cell lines MiaPaCa-2 and PANC-1, an in vitro analysis of the synergistic effect using 5-fluorouracil in conjugation with Pluronic® F127 was performed. By monitoring cell viability and regulation of cell cycle, we were able …
-
Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. Our current research uses an improved Modified Vaccinia Ankara poxvirus …
-
Trends in Receipt and Timing of Multimodality Therapy in Early-Stage Pancreatic Cancer
Introduction Pancreatic cancer is considered a systemic disease at presentation. Therefore, multimodality therapy with surgical resection and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regard to age and treatment center in the …
-
Trends in Receipt and Timing of Multimodality Therapy in Early-Stage Pancreatic Cancer
Introduction Pancreatic cancer is considered a systemic disease at presentation. Therefore, multimodality therapy with surgical resection and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regard to age and treatment center in the …
-
Trends in Receipt and Timing of Multimodality Therapy in Early Stage Pancreatic
INTRODUCTION: Pancreatic cancer is considered a systemic disease at presentation. Therefore, multimodality therapy with surgical resection and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regards to age and treatment center in …
-
Rational drug combinations to selectively target 9p21-deleted bladder cancer
… the efficacy of these combinations in pancreatic adenocarcinoma and pleural mesothelioma cells with 9p21 loss, suggesting that other tumor types may benefit from these treatments. We recognize that while this study is limited by the lack of validation in more complex cancer models the …
-
Investigation of pancreatic beta cell differentiation and function, and global profiling analysis of diabetes serum for the identification of disease biomarkers
… a possible route for generation of human pancreatic beta cells for the study of regulated insulin secretion. Attempts were made to generate iPS cells from the MiaPaCa2 pancreatic adenocarcinoma cell-line, normal human epidermal keratinocytes, and normal human limbal epithelial cells. …
-
Stability and Robustness of Radiomic Features Due to Volumetric Uncertainty in Pancreatic Cancer
… highly depends on the tumor site, and pancreatic adenocarcinoma (PDAC) is among the most difficult to delineate and therefore more likely to be affected. No studies to date have investigated the impact of interobserver variability on the stability and robustness of CT derived radiomic …
-
The Role and Mechanism of Enhanced Met Expression in Pancreatic Cancer
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States annually and little progress has been made in the past 30 years to improve patient survival. Therefore, it is imperative the signaling pathways that drive pancreatic cancer growth and progression be identified and …
-
Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy
… Castration resistant prostate cancer (CRPC) and pancreatic adenocarcinoma (PDAC) are two common lethal cancers that remain refractory to checkpoint blockade, requiring development of new therapeutic approaches to promote responsivity in patients with these diseases. Both CRPC and PDAC are …
-
Prognostic Significance of Xct Polymorphisms and Expression In Patients With Advanced Pancreatic Cancer Treated With Chemotherapy
… glutamate and is highly expressed by pancreatic cancer cells. The <em>xCT</em> gene, encoding the cystine-specific xCT protein subunit of x<sub>c</sub><sup>-</sup>, is important in regulating intracellular glutathione (GSH) levels, critical for cancer cell protection against oxidative …
-
Hypoxia Activated Prodrug and Anti-Angiogenic Therapy Cooperate to Treat Pancreatic Cancer But Elicit Immune Suppressive G-Mdsc Infiltration
… (KPC) derived model of pancreatic adenocarcinoma (PDAC) to examine the tumor response to and adaptive resistance mechanisms engaged by therapy with two established methods of hypoxia-reducing therapy: the hypoxia-activated prodrug TH-302 and vascular endothelial growth …
Page 1 of 2