Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"pancreatic acinar cells"”.
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Tumour suppression mediated through DPC4, p53 and APC
… suppressor genes SMAD4 (or DPC4, deleted in pancreatic cancer locus 4), APC (adenomatous polyposis coli) and p53 have been implicated in pancreatic cancer in humans. This thesis firstly documents the in vivo effects of mutations in these genes singly and in combination through spontaneous and …
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Molecular mechanism of magnesium transport in epithelial cells
… acid (HCI) secretion and Ca 2 homeostasis in the pancreatic acinar cells and parietal cells and (b) to characterise the molecular mechanism of Mg 2 transport using fluorimetric and spectroscopic studies. The results have shown that application of either cholecystokinin-octapeptide (CCK-8) or …
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The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels
Pancreatic acinar cell exocytosis requires precise calcium (Ca2+) signals. When cytosolic Ca2+ levels remain high, cellular functions are disrupted, which is associated with initiation of pancreatitis. Ca2+ signals are achieved through regulating endoplasmic reticulum (ER) stores, Ca2+ATPases, and …
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Establishing The Role Of The Pancreatic Transcription Factor Mist1 In Xbp1-Mediated Maintenance Of Pancreatic Acinar Cell Homeostasis
<p>Pancreatic acinar cells (PACs) continuously produce more protein than any other cell type in the human body. As a result, PACs and other specialized secretory cells have a constant demand placed on their protein synthetic and packaging machinery. When demand for secreted products exceeds the …
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LINEAGE TRACING ANALYSIS OF PANCREATIC ACINAR CELL DE DIFFERENTIATION AND TRANS-DIFFERENTIATION IN VITRO AND IN VIVO IN THE ABSENCE OF MIST 1
Previous studies suggest that mature pancreatic acinar cells can trans- differentiate into duct and islet cells in vitro; however, the intrinsic factors regulating this process have not been defined. The acinar specific transcription factor MIST1 is required for acinar cell maturation and targeted …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
The decision of pancreatic precursor cells to differentiate into acinar or endocrine cells is regulated by a complex network of signaling and transcription factor pathways. P48 is a tissue-specific basic-helix-loop-helix (bHLH) transcription factor, which is essential for pancreas development and …
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Prevention of Acute Pancreatitis by Broccoli Components
… and refractory inflammatory disease affecting pancreatic acinar cells. Annually 300,000 patients are hospitalized. Attempts to halt the progression of the disease with anti-inflammatory drugs once pancreatitis has developed have been inconsistent. One promising area of research is preventive …
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Cellular Mechanism of Exocrine Pancreatic Insufficiency in Diabetes Mellitus
… This complication is described as exocrine pancreatic insufficiency. Whilst this causes malnutrition in patients and contributes to diabetic morbidity, the physiology and molecular biology leading to this state is not well defined. This disease-induced inability to digest foodstuffs could …
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Transcriptomic analysis of pancreatic cells in zebrafish
… the metabolism of all vertebrates. The endocrine cells are mainly grouped into the islets of Langerhans and secrete distinct hormones, such as glucagon (α-cell), insulin (β-cell), somatostatin (δ-cell) and ghrelin (ε-cell). Diabetes occurs when insulin production by the β-cells is unable to …
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Connective Tissue Growth Factor in Pancreatitis
… inflammatory condition of the pancreas in which pancreatic acinar cells (PAC) become injured by noxious agents and produce pro-inflammatory mediators. Excessive alcohol consumption is a major cause of pancreatitis in the West. Acute pancreatitis (AP) can be recurrent and severe, leading to …
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Mechanism of exocrine pancreatic insufficiency during diabetes mellitus
… free magnesium concentration ([Mg2 ]) and pancreatic juice secretion in the isolated pancreatic segments and the anaesthetised rat preparations of diabetic and age-matched control rats. Alter 6-8 weeks of diabetes induction, diabetic rats in all the experimental groups weighed significantly …