Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 830 for “"pancreatic"”.
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
Pancreatic cancer (PC) is a lethal malignancy characterised by chemoresistance and metastatic spread. This is largely due to the presence of dense stromal fibrosis which distorts tumour vasculature. This limits nutrient, oxygen and chemotherapy perfusion into pancreatic tumours and promotes …
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Cryopreservation of pancreatic islets
Pancreatic islet transplantation is a curative treatment for diabetes but access to this therapy is limited by the availability of islets. Long-term cryopreservation of islets could partially address this limitation but current cryopreservation protocols, which use the toxic cryoprotectant dimethyl …
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3D bioprinting of pancreatic islets
Hintergrund/Ziel: Um Langzeitkomplikationen bei Diabetes mellitus Typ 1 (T1D) zu verhindern, können Spenderinseln transplantiert werden, was allerdings lebenslange rigorose Immunsuppression erfordert. Durch Verkapselung der Inselzellen kann die Immunsuppression umgangen werden, aber Upscaling ist …
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Integrin alpha6beta4 contributions in pancreatic adenocarcinoma
Pancreatic adenocarcinomas are among the most lethal human cancers due to an elevated incidence of tumor cell invasion and metastasis for reasons that are currently unclear. In this dissertation, I determined how the pro-invasive integrin alpha6beta4 expression was related to pancreatic …
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Fibroblast Heterogeneity In Pancreatic Cancer Immunity
… were thought to be a barrier to treatment of pancreatic ductal adenocarcinoma (PDAC). However, general stromal targeting strategies have largely failed in the clinic likely due to the heterogeneity of CAFs in the TME. Therefore, our groups and others have worked to unravel the heterogeneity of …
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
<p>Pancreatic cancer is one of the most lethal type of cancer due to its high metastasis rate and resistance to chemotherapy. Pancreatic fibrosis is a constant pathological feature of chronic pancreatitis and the hyperactive stroma associated with pancreatic cancer. Strong evidence supports an …
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The Mechanism of Tumorigenesis In The Immortalized Human Pancreatic Cell Lines: Cell Culture Models of Human Pancreatic Cancer
… of tumorigenesis in the immortalized human pancreatic cell lines: cell culture models of human pancreatic cancer</strong></p> <p><strong> </strong></p> <p>Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer in the world. The most common genetic lesions identified in PDAC …
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Establishing The Role Of The Pancreatic Transcription Factor Mist1 In Xbp1-Mediated Maintenance Of Pancreatic Acinar Cell Homeostasis
<p>Pancreatic acinar cells (PACs) continuously produce more protein than any other cell type in the human body. As a result, PACs and other specialized secretory cells have a constant demand placed on their protein synthetic and packaging machinery. When demand for secreted products exceeds the …
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Characterising the crosstalk between pancreatic fibroblasts and group 2 innate lymphoid cells in pancreatic homeostasis, inflammation, and neoplasia
… as the importance of fibroblast contributions to pancreatic pathologies, in this thesis I characterised fibroblast and ILC2 populations in the pancreas and defined the mechanisms of their bi-directional communication in homeostatic, inflamed, and neoplastic states. The majority of pancreatic ILC2s …
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Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma
… in high amounts in some cancers, including pancreatic ductal adenocarcinoma (PDAC). There have been several published studies regarding CYP3A5 regulators, but there is still much to be discovered concerning CYP3A5 regulation in cancer. To further understand the regulation of CYP3A5, a …
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Mitochondrial Involvement in Pancreatic Beta Cell Glucolipotoxicity
… free fatty acid (NEFA) levels can cause pancreatic β-cell failure. The molecular mechanisms of this β-cell glucolipotoxicity are yet to be established conclusively. In this thesis by exploring mitochondrial energy metabolism in INS-1E insulinoma cells and isolated pancreatic islets, a …
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T Cell Immunosurveillance in Pancreatic Ductal Adenocarcinoma
ABSTRACT T CELL IMMUNOSURVEILLANCE IN PANCREATIC DUCTAL ADENOCARCINOMA Rebecca A. Evans Robert H. Vonderheide The prevailing theory of cancer immune surveillance, as understood from carcinogen-driven mouse models of highly mutated tumors, states that T cell-mediated immune pressure drives a …
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Transcriptomic analysis of pancreatic cells in zebrafish
… determine the transcriptomic signatures of each pancreatic cell type in zebrafish in order to identify novel cell type-specific regulatory genes that might be crucial for their differentiation and/or physiology. Pancreatic acinar cells, ductal cells as well as the endocrine α-, β- and δ-cells …
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The test meal and exocrine pancreatic function
… to animals, where it was possible to construct a pancreatic fistula and thus collect pure pancreatic juice. In addition, pancreatic tissue from animals was also obtainable relatively easily. Early attempts to study the pancreas in man was restricted to patients with pancreatic fistulae, usually …
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A Predictive Model for Pancreatic Cancer Diagnosis
Pancreatic ductal adenocarcinoma (PDAC), a specific type of pancreatic cancer, has a five-year survival rate of 8.5% and is the third-deadliest cancer in the United States. However, earlier detection can raise survival rates dramatically. In this thesis, we investigate the hypothesis that …
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Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells
… variant signaling on the health and function of pancreatic β-cells. The variants of ERα differ in the presence of two activation function (AF) domains, which regulate transcriptional activities. ERα66 possesses both domains, ERα46 lacks the AF-1 domain, and ERα36 lacks both the AF-1 and AF-2 …
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FUNCTIONAL ANALYSIS OF RABBIT PANCREATIC CELLS IN VITRO.
FUNCTIONAL ANALYSIS OF RABBIT PANCREATIC CELLS IN VITRO.
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iPLA2β, ALTERNATIVE SPLICING AND APOPTOSIS OF PANCREATIC ISLETS
<p>Ceramides are bioactive lipids that can promote splicing of apoptosis-related genes, including caspase 9 and BCL-x. A recent study demonstrated that expression of neutral sphingomyelinase (NSMase), an enzyme that hydrolyzes sphingomyelins to generate ceramide, is regulated by Group VIA …
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