Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"pancreas development"”.
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The role of N-cadherin and S1P/S1P1 in pancreas development
… epithelial and mesenchymal tissues. During pancreas development, mesenchyme-derived structures induce specification, growth and differentiation of pancreatic epithelial cells. For instance, notochord, endothelial cells, and pancreatic mesenchyme are essential for the development of the …
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Primate-specific KRAB zinc finger proteins and their targets rewire regulatory networks related to inflammation and pancreas development
… during the early stages of pancreatic development and binds on members of primate conserved MER11 elements leading to their epigenetic silencing. On the other hand, ZNF267 is already highly expressed in monocytes and macrophages but it is further upregulated by inflammatory stimuli. …
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The use of human pluripotent stem cells to model HNF1B-associated diabetes
… However, the mechanisms that underlie development of diabetes in HNF1B mutation carriers are still not fully understood due to lack of an appropriate model system. Human induced pluripotent stem cells (hiPSCs), which are capable of self-renewal and can differentiate into any cell type, …
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Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function
… of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. So far, the most …
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Understanding the Role of Hypusine Biosynthesis in Endocrine-Exocrine Crosstalk
… and endocrine cellular compartments of the pancreas have been considered distinct functional systems. However, recent studies suggest a more intricate relationship between the exocrine and endocrine, which may impact pancreatic growth and health. Additionally, translational control …
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TMEM27: A Cleaved and Shed Plasma Membrane Protein That Stimulates Pancreatic Beta Cell Proliferation
… mice with marked hypertrophy of the endocrine pancreas. Tmem27 is expressed in hormone positive cells at early stages of pancreas development and becomes restricted to pancreatic β cells in the mature pancreas. Biochemical characterization revealed that the Tmem27 exists as a dimer and that its …
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Rab11 Regulates Lumen Formation and Morphogenesis in the Developing Pancreas
… and tissue-level morphogenesis in the pancreas remain elusive despite a decade of studies. Here, I show that deletion of Rab11A and Rab11B (Rab11) in the developing pancreatic epithelium (Rab11pancDKO) disrupts both of these processes. The loss of Rab11 in the pancreas results in ~50% …
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FGF signaling in specification of hESC-derived definitive endoderm
… experimental assay for understanding human pancreas development. Pancreas originates from the definitive endoderm (DE), one of the three germ layers. The path from definitive endoderm to pancreatic progenitor cells and finally the insulin producing beta cells involves sequential cell-fate …
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Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm
… independent and presumably also delay the development of complications. However, the increasing number of diabetic patients would require large amounts of transplantable insulin producing cells. Due to the fact that islet donor material is a limiting factor for transplantations, human …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… transcription factor, which is essential for pancreas development and function. Mice lacking both p48 alleles lack an exocrine pancreas and have a greatly reduced endocrine pancreas. The active form of P48 is the heterotrimeric complex, PTF1. This complex binds and regulates the transcription …
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A TRIM28 centric strategy to efficiently uncover the contribution of KZFPs to the evolution of gene regulatory networks
… as an essential primate-specific regulator of pancreas development via the regulation of MER11 elements which, when derepressed, are able to trigger a liver cell fate program. Here I present a new large-scale strategy to uncover links between KZFPs, TEs and gene regulation. We leverage the …
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The Role of Sox17 in Normal and Pathological Beta Cell
… factor and a key regulator in various developmental and disease contexts. During endoderm development, Sox17 acts, in part, by transcriptionally regulating other important endodermal transcription factors including HNF1β and Foxa2, which are also known regulators of postnatal β cell …
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Transcriptomic analysis of pancreatic cells in zebrafish
Pancreas is a mixed gland composed of endocrine and exocrine tissues and plays a crucial role in the metabolism of all vertebrates. The endocrine cells are mainly grouped into the islets of Langerhans and secrete distinct hormones, such as glucagon (α-cell), insulin (β-cell), somatostatin (δ-cell) …
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Struktur- und Funktionsanalysen des Pax4-Promotors
Pax4 gehört zu einer neunköpftigen Familie von Transkriptionsfaktoren mit einem paired box Sequenzm otiv. Inaktivierung von Pax4 führt zu einem Ausbleiben der Ausreifung von Insulin produzierenden Be ta-Zellen und Somatostatin produzierenden Delta-Zellen. Die vorliegende Arbeit beschreibt die Eingr …