Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"pan-cancer analysis"”.
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Pan-Cancer Analysis of Non-Coding Driver Mutations
Cancers are caused by genomic alterations known as drivers. As drivers have broad applications in precision oncology, their discovery has become one of the central motivations for cancer genomics. At present, the majority of drivers have been found in the ~2% protein-coding regions. Despite an …
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Pan-Cancer Analysis of RNA Dysregulation, Somatic Mutations, and Matrix Stiffness using Bioinformatics Approaches
Cancer is a complex disease driven by genetic mutations, epigenetic modifications, and alterations in the tumor microenvironment. Understanding these intricate molecular mechanisms is crucial for advancing cancer diagnosis, prognosis, and treatment. RNA sequencing (RNA-seq) has emerged as a …
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Systems biology of deregulated splicing in cancer. A pan-cancer analysis of dysfunctional splicing machinery and alternative splicing events.
… this project, we set out to perform a systematic analysis of aberrant splicing events in cancer cell lines from two perspectives: deregulated splicing because of dysfunctional splicing factors and the appearance of de novo splicing events because of splice-disruption mutations in the DNA sequence. …
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Investigation of Genetic Alterations In Emt Suppressor, Dear1, Through Pan-Cancer Analysis and Ultra-Deep Targeted Sequencing In Ductal Carcinoma In Situ
… predictive and prognostic biomarkers for breast cancers with a heightened risk of progression from DCIS to IDC. Our laboratory has previously discovered a novel TRIM family member, <em>DEAR1</em> (<em>Ductal Epithelium Associated Ring Chromosome 1, annotated as TRIM62)</em> within chromosome …
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TimiGP: A Computational Framework to Determine the Tumor Immune Microenvironment Associated with Prognosis and Immunotherapy Response
… microenvironment (TIME) drastically impacts cancer patients’ clinical outcomes, including prognosis and immunotherapy response. However, understanding TIME remains challenging due to its complexity and heterogeneity. In this dissertation, we introduce TimiGP (Tumor Immune Microenvironment …
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The Intra-Tumour Heterogeneity Landscape of Human Cancers
… a selective advantage and can induce clonal expansions. Incomplete clonal expansions give rise to intra-tumour heterogeneity. Somatic mutations can be measured through massively parallel sequencing, where mutations that are supporting incomplete expansions will appear as subclonal. These …
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Patterns of somatic genome rearrangement in human cancer
Cancer development is driven by somatic genome alterations, ranging from single point mutations to larger structural variants (SV) affecting kilobases to megabases of one or more chromosomes. Studies of somatic rearrangement have previously been limited by a paucity of whole genome sequencing data, …
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Integrative network modeling of large multidimensional cancer datasets
… containing measurements from thousands of cancer tumors. To harness the potential of the amassing data sets, we introduce new modeling techniques and generalise existing methods for large-scale integration of cancer data. These methods aim to construct network models that link genetic, …
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Signatures of chromosomal instability in human cancers
… molecular characteristics to be described in cancer. Since its detection by light microscopy in the late 19th century, technological advances have facilitated the observation of CIN at increasing resolution, revealing an extreme genomic complexity which we are only beginning to understand. As …