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Showing 1 to 14 of 14 for “"pamam dendrimers"”.
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Synthesis and modification of pamam dendrimers as histone replacement molecules
… synthesise and structurally modify a series of PAMAM dendrimers with a view to investigating and controlling their complexation with, and compaction of, DNA. The Introduction gives an overview to the origins of polymer and dendrimer science, and describes the synthetic approaches and resulting …
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Surface Tethered PAMAM Dendrimers On Controlled Pore Glass As Color Release Sensors For Phosphates
<p>Poly(amidoamine) dendrimer (PAMAM) are highly branched macromolecules with reactive amine groups in their interior and exterior. PAMAM dendrimers were attached to controlled pore glass (CPG) surfaces in order to create new functionalized surfaces and used as platforms for UV-vis and fluorescent …
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Design Of Functional Dendrimer Nanocarriers And Their Formulations In Propellant-Based Inhalers For Pulmonary Drug Delivery
… ratio. </p> <p>The second challenge is to design PAMAM functional dendrimer nanocarriers for the delivery of therapeutics to and through the lungs. Using molecular dynamics simulations, we investigate the microstructures of PAMAM dendrimers as a function of generation, PEGylation density, …
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Sensitive Detection of Foodborne E. coli O157:H7 by Dendrimer-aptamer Modified Microchannels - with RCA Signal Intensifications
… the proposed detection system, poly(amidoamine (PAMAM) dendrimers are immobilized onto inner surfaces of polydimethyl siloxane (PDMS) microchannels to avoid non-specific binding and to provide more binding sites to subsequently conjugate capturing aptamers as recognition elements. Surface …
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Studies of multicomponent assemblies
… is divided into three major sections (one on dendrimers, one on tripodal metal ligands and one on a research oriented chemistry curricula) with a primary focus on different types of multicomponent assemblies. In the first chapter, a system is described that used a multicomponent assembly of …
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An Investigation of The Use of Dendrimer-Based Carrier to Cross Cellular Barrier
Dendrimers are a novel class of highly branched polymers with a high degree of uniformity and monodispersity. As a result of the unique properties and characteristics of dendrimers, they have found a wide range of pharmaceutical applications. This study investigated the ability of polyamidoamine …
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Dendrimer Modified Silica Nanoparticles as Fluorescent Chemosensors for the Detection of Copper and Cyanide Ions
… were modified with branching polyamidoamine (PAMAM) dendrimers, which function as selective turn-off Cu<sup>2+ </sup>ion chelators and platforms for the attachment of rhodamine isothiocyanate (RITC) or fluorescein isothiocyanate (FITC) fluorescent dyes. In the presence of Cu<sup>2+ </sup>ions, …
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Stabilization of transition states of organic reactions by cyclodextrins, micelles, and dendrimers
… the substrate. Amino- and carboxylate-terminated dendrimers modestly catalyze the basic cleavage of p-nitrophenyl alkanoates. Both substrate and transition state binding are independent on the ester acyl chain length, but were found to be a function of the dendrimer generation number. …
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Molecular Modeling Studies of Dendrimers and Hyperbranched Polymers
… the conformational and rheological dynamics of dendrimers and hyperbranched polymers is investigated. Non-Equilibrium Brownian Dynamics (NEBD) simulations are utilized to investigate the single-molecule behavior in the dilute solution and the Tube Model is utilized to investigate the dynamics in …
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Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
<p>PAMAM dendrimers are a class of well-defined, hyperbranched polymeric nanocarriers that are being investigated for ocular drug and gene delivery. Their favorable properties such as small size, multivalency and water solubility can provide significant opportunities for many biologically unstable …
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Weak intermolecular interactions as binding probes and analytical tools
… supramolecular chemistry. Poly(amidoamine), or PAMAM, dendrimers are hyperbranched polyelectrolytes that can bind to small charged molecules through non-covalent interactions. These supramolecular structures are often involved in cooperative binding events to guest molecules in which they …
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Synthesis and Activation of Nanoscale Dendrimer-Derived Supported Noble Metal Catalysts
<p>In recent years, PAMAM dendrimers have been used as templates for the preparation of supported metal catalysts. This approach takes advantage of several unique characteristics of these dendrimers such as the ability to complex metal cations in solution and to protect them from aggregation until …
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Polyphosphate is a novel modulator of coagulation and inflammation and is a therapeutic target
… such as polyethylenimine, polyamidoamine (PAMAM) dendrimers and polymyxin B, while attenuating thrombosis, all had significant toxicity in vivo, likely due to the presence of multiple primary amines responsible for their polyP binding ability. In collaboration with the Kizhakkedathu lab at …