Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"pamam"”.
-
Pamam dendrimer-based therapeutic and diagnostic nanodevices
… Hydroxyl terminated poly(amidoamine) dendrimer (PAMAM-OH) was modified with a linker having amine group at the end and conjugated to two drugs, erythromycin (EM) and allopregnanonolne, respectively and evaluated in vitro. Both drugs were provided with a linker having carboxylic group required for …
-
Synthesis and modification of pamam dendrimers as histone replacement molecules
… synthesise and structurally modify a series of PAMAM dendrimers with a view to investigating and controlling their complexation with, and compaction of, DNA. The Introduction gives an overview to the origins of polymer and dendrimer science, and describes the synthetic approaches and resulting …
-
Molecular simulations of dendritic molecules : a study of PAMAM and phenyl-acetylene dendrimers
Dendrimers are branched molecules that often have chemical properties similar to proteins and other large organic molecules. Dendrimers presently have applications as reactive surfaces for catalysis, and as hosts for drug delivery. Computer simulations of dendritic molecules are difficult due to …
-
Surface Tethered PAMAM Dendrimers On Controlled Pore Glass As Color Release Sensors For Phosphates
<p>Poly(amidoamine) dendrimer (PAMAM) are highly branched macromolecules with reactive amine groups in their interior and exterior. PAMAM dendrimers were attached to controlled pore glass (CPG) surfaces in order to create new functionalized surfaces and used as platforms for UV-vis and fluorescent …
-
Synthesis and characterization of polyamidoamine dendrons
… of this study is to synthesize Poly AMido AMine (PAMAM) dendrons using silica gel as support and characterize them. PAMAM dendron, a hyperbranch of the PAMAM dendrimer, was divergently synthesized on solid support. Prior to the propagation through (1) Michael addition of acryl ester to an amino …
-
Determination of permeability-surface area products of GD-DTPA and PAMAM-TU-DTPA G = 4 magnetic resonance imaging contrast agents in mammary tumors
Open Restriction set for Item 97290 on 2016-12-14T22:51:35Z with date null by astein@illinois.edu.
-
An Investigation of The Use of Dendrimer-Based Carrier to Cross Cellular Barrier
… investigated the ability of polyamidoamine (PAMAM) dendrimer-based drug delivery systems to enhance the permeability of a drug that is a substrate of P-glycoprotein (P-gp) efflux transporter with low water solubility. This thesis described the syntheses, characterisations and biological …
-
Design Of Functional Dendrimer Nanocarriers And Their Formulations In Propellant-Based Inhalers For Pulmonary Drug Delivery
… ratio. </p> <p>The second challenge is to design PAMAM functional dendrimer nanocarriers for the delivery of therapeutics to and through the lungs. Using molecular dynamics simulations, we investigate the microstructures of PAMAM dendrimers as a function of generation, PEGylation density, …
-
Development of Dendritic Polymers as a Modular Drug Delivery Platform for Avascular Tissues
… modified with poly(ethylene glycol) chains (PEG-PAMAM conjugates) have shown promise in electrostatic based drug delivery to articular cartilage to treat osteoarthritis (OA), a debilitating disease of synovial joints affecting millions of people. Currently, there are no cures for OA. Though …
-
Weak intermolecular interactions as binding probes and analytical tools
… supramolecular chemistry. Poly(amidoamine), or PAMAM, dendrimers are hyperbranched polyelectrolytes that can bind to small charged molecules through non-covalent interactions. These supramolecular structures are often involved in cooperative binding events to guest molecules in which they …
-
PFG-NMR Untersuchungen zu Skalenverhalten, effektiver Größe und Lösungsverhalten von Dendrimeren
… konnte abgeleitet werden, dass das Verhalten der PAMAM-Dendrimere dem von Proteinen ähnelt, die Dendrimere also starr und globulär sind. Um die Abhängigkeit des hydrodynamischen Radius von der Molmasse zu untersuchen, kamen Lösungen von mehreren Generationen PAMAM-Dendrimeren mit verschiedenen …
-
Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
… first direct examination of the polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimer core cavities was reported by a previous research group member. This previous work revealed the need to further understand the sequestering abilities and host-guest properties of these materials. …
-
Influence on molecular geometry and chain conformation on properties of polyelectrolyte multilayers
… imine) (BPEI), or poly(amidoamine) (PAMAM) dendrimer, generation four, amine surface. Various properties of these films are compared; including film thickness, chemical functional group availability, and film composition. Carboxylic acid group ionization is found to increase with …
-
Synthesis and Activation of Nanoscale Dendrimer-Derived Supported Noble Metal Catalysts
<p>In recent years, PAMAM dendrimers have been used as templates for the preparation of supported metal catalysts. This approach takes advantage of several unique characteristics of these dendrimers such as the ability to complex metal cations in solution and to protect them from aggregation until …
-
Effect of combinations of drugs on glioma chemotherapy
… of novel generation 3 (03) polyamidoamine (PAMAM) dendrimer to chemotherapeutic agent, Paclitaxel. The cytotoxicity results showed that paclitaxel, when conjugated to the 03 PAMAM dendrimer, was significantly more toxic then when used alone. P-glycoprotein (Pgp) is the major hurdle in the …
-
Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
… this work, we desgined polyamidoamine dendrimer (PAMAM) conjugates which can only release DOX intracellularly, while being stable in physiological environment. We observed the PAMAM-DOX conjugates upon local delivery to the lungs can significantly inhibit tumor growth both in vitro and in vivo. We …
-
Sensitive Detection of Foodborne E. coli O157:H7 by Dendrimer-aptamer Modified Microchannels - with RCA Signal Intensifications
… the proposed detection system, poly(amidoamine (PAMAM) dendrimers are immobilized onto inner surfaces of polydimethyl siloxane (PDMS) microchannels to avoid non-specific binding and to provide more binding sites to subsequently conjugate capturing aptamers as recognition elements. Surface …
-
Amphiphilic linear-dendritic block copolymers for drug delivery
… block copolymer consisting of poly(amidoamine) (PAMAM) and poly(propylene oxide) (PPO) was synthesized. In order to determine the viability of the linear-dendritic block copolymer as a drug delivery vehicle, the solution-phase self-assembly behavior and the self-assembled structures were …
-
Quell- und Transportverhalten von thermosensitiven Hydrogelen
… die Diffusion von synthetischen Makromolekülen, PAMAM-Dendrimeren, im Gelnetzwerk mit Hilfe der Holographischen Relaxationsspektroskopie (HRS) gemessen. Durch die Verwendung von Dendrimeren unterschiedlicher Größe können Rückschlüsse auf die innere dynamische Porenstruktur der Gele gezogen werden.
-
Self-assembly of linear-dendritic diblock copolymers
… polyethylene oxide (PEO) with a polyamidoamine (PAMAM) dendron covalently bonded to one chain end. Specular neutron reflectivity has been used to investigate the structure of monolayers formed at an air-water interface. The dendritic end groups were functionalized with deuterated stearic acid to …
Page 1 of 2