Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"pain modulation"”.
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Functional MRI Investigation of the Neural Basis of Human Pain Processing in the Brainstem and Spinal Cord; Descending Regulation and Chronic Pain
Pain is a complex experience that includes sensory components, descending pain modulation, and cognitive and emotional effects. A combination of any or all of these effects may be altered in chronic pain conditions. The objective of this thesis was to investigate how network connectivity is altered …
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The effect of a muscle energy stretch on suboccipital tenderness
… of manual therapy as a means of treating spinal pain and dysfunction, but there is little evidence of its role in pain modulation. This controlled and single blinded study aimed to investigate the effect of MET on pressure pain thresholds (PPT) in the suboccipital musculature in an asymptomatic …
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Role of Rostromedial Tegmental Nucleus Afferents in Symptoms of Withdrawal from Chronic Ethanol Exposure
… of withdrawal symptoms including heightened pain sensitivity. Although common, the precise neural mechanisms underlying nociceptive symptoms of withdrawal are not well understood. The rostromedial tegmental nucleus (RMTg) is a GABAergic region that plays a critical role in avoidance behavior, …
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Central and peripheral mechanisms of pain modulationthe role of the Locus coeruleus and pupillary dynamics in neuropathic and inflammatory pain
Pain is a complex sensory and emotional experience that results from the interaction between peripheral nociceptive input and central processing in the nervous system. Despite its clinical relevance and social impact, the management of pain, particularly chronic pain remains a significant …
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Régulation du récepteur aux opioïdes de type delta par les protéines Homer1
… a promising therapeutic target for chronic pain management. However, DOP mainly localizes to intracellular compartments whereas its analgesic effects occur when translocated to the plasma membrane. The mechanisms involved in its trafficking remain also poorly known. Recently, liquid …
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The Relationship Between Psychosocial Functioning and Diffuse Noxious Inhibitory Control Function in Women With Provoked Vestibulodynia and Pain Free Controls
… (PVD) is the most common form of chronic vulvar pain, affecting 12% of women in the general population. PVD is characterized by a severe burning pain in response to pressure localized to the vaginal entrance. Research examining the pain component of PVD indicates that it has much in common with …
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The Effects of Cannabidiol and Analgesic Expectancies on Experimental Pain Reactivity in Healthy Adults: A Balanced Placebo Design Trial
<p>Experimental pain trials have been unable to determine whether cannabinoid analgesia is attributable to intoxication, analgesic expectancies, and/or pharmacological action. One approach to resolving this issue involves testing the effects of analgesic expectancies and cannabidiol (CBD), a …
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Effects of Music on the Pain Response in the Central Nervous System Using Functional Magnetic Resonance Imaging
The oldest procedure for pain relief has been music. There is abundant behavioural evidence to support music’s pain relieving properties, however, studies to date have yet to investigate music-induced analgesia via imaging. Our first imaging study used thermal stimulation just below pain threshold …
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The computational modelling of the spinal cord neurons involved in the pain process
Pain is a personal subjective experience with physiological and psychological components and involves many complex processes. In 1965 Melzack and Wall proposed the influential gate control theory (GCT) of pain and, in general, this has been supported by subsequent research. This theory postulates …
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Cyclodextrins as a suitable carrier for the induction of feeding and analgesia by Delta-9 THC: a preclinical study in the female rat
… analyses quantified dopamine (DA) levels in pain- and reward-related brain regions (periaqueductal gray, ventral tegmental area, nucleus accumbens, and prefrontal cortex). Additionally, hepatic concentrations of THC, its principal metabolites (11-OH-THC and 11-COOH-THC), and fatty acid …
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Creation of a Virtual Interface for Stress-Trauma Investigations through Open World Navigation: An Exploration of Tolerability and Physiological Reactions
… (MVC). In Chapter 2, we evaluated conditioned pain modulation (CPM) in reaction to the cold pressor task and measured associations with indices of sympathetic and hypothalamic-pituitary-adrenal function. It was found that only 30% of participants experienced inhibitory CPM. Within this group, …
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Effects of dry needling and therapeutic exercise on sleep in individuals with chronic neck pain and sleep disturbance: A pilot randomized clinical trial
… a bidirectional relationship between sleep and pain, non-pharmacological interventions are lacking to address both sleep dysfunction and pain together. Therefore, research that investigates the effects of non-pharmacological interventions not only on pain but also on sleep dysfunction is …
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Characterizing Effects of Sphingosine-1-Phosphate Receptor 1 Activation in Subtypes of Central Amygdala Neurons and Effects of Prenatal Methadone Exposure on Motor Cortex Neurons in Mice
… sclerosis and studied as a treatment for pain. The primary cellular response to S1P is thought to be elicited through S1PR type 1 (S1PR1). My first goal was to understand how S1PR1 signaling affects neuronal excitability in the central amygdala (CeA), a supraspinal node of the descending …
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The aetiology of pain in chronic midportion Achilles tendinopathy
… and sedentary individuals, which presents as pain and loss of function in the lower limb. Tendon pathology can exist without pain, but the hallmark of the condition is pain, which is classically of insidious onset, related to loading activity and often resistant to treatment. While the biology …
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Utilisation des mécanismes endogènes de modulation de la douleur en contexte clinique : élaboration de valeurs normatives, mesure de la fidélité test-retest et développement et validation d’un modèle de prédiction
Introduction : Les mécanismes de modulation de la douleur sont des processus physiologiques qui régulent la perception de la douleur. La sommation temporelle (ST - mécanismes excitateurs) et les CPM (mécanismes inhibiteurs) ont particulièrement été étudiés à cet égard. D'une part, ils apparaissent …
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A TALE OF TWO STRESS MODULATORS: EFFECT OF DELTA OPIOID RECEPTOR AGONISM AND FKBP5 INHIBITION ON GENE EXPRESSION AND BEHAVIOR DURING COCAINE WITHDRAWAL
… Delta opioid receptors (DOR) are involved in pain modulation and further play a role in the regulation of mood. Delta opioid agonists can reduce stress-induced and cocaine withdrawal-induced negative affect in rodents. Although the mechanism underlying this effect is unclear, DOR and CRF are …
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Temporal Dynamics of Heat Pain Sensations
The moment-to-moment fluctuations in pain-evoked sensory and emotional qualities, and how the pain experience differs between sexes are not well understood. Therefore, this thesis sought to 1) characterise the temporal profiles of the most prominent noxious heat-evoked sensations, 2) characterise …