Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"pain mechanisms"”.
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Behavioral Insights Into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms In Rats
<p>Postsurgical and neuropathic pain are each clinically common, and often associated with ongoing pain. Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors. Preclinical studies using rodent neuropathic models have concentrated on allodynia driven by OA generated in …
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Quantification and Evaluation of the Biomechanical Behaviour of the Trunk During Fundamental Tasks: Should the Thoracic Spine be Considered?
… spine mechanics may provide insight into pain mechanisms in both spine regions. This dissertation quantified and evaluated the biomechanical behaviour of the thoracic spine during fundamental tasks, to determine if monitoring the thoracic spine is necessary in the investigation of spine …
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Statistical Learning Methods for Challenges arised from Self-Reported Data
… methods and analyzing data arised from chronic pain (CP) studies, with a particular emphasis on the unique challenges posed by self-reported (SR) data. Latent class analysis (LCA) is explored in the early stages of this work to cluster patients, and the clusters are compared to find features …
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The role of Substance P and its signaling pathways in central sensitization
… activation in a capsaicin-induced exaggerated pain state in rats. A significant increase of SP in rat dorsal horn was observed after capsaicin injection. Electrophysiological and behavioral results showed that NK-1 activation is required for the development of central sensitization.\r\nRecent …
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Impact of environmental and genetic factors on pain sensitivity and chronic pain development
Chronic pain is a significant clinical burden and available treatments are inadequate. Progress has been made in understanding and targeting underlying pain mechanisms but to target pain efficiently, we must understand why some patients are more vulnerable to developing chronic pain than others. …
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Mechanisms of synovial fluid lipid-mediated neuronal sensitisation in arthritis
… billions to the global economy. Although joint pain is the leading patient-reported symptom of those with arthritis, current analgesics often fail to produce consistent pain relief and, with chronic use, are associated with detrimental side effects. Osteoarthritis (OA) is the most common form of …
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Pain alleviating effects of mesenchymal stem/stromal cells and derived extracellular vesicles in osteoarthritis
… old. It is characterised by debilitating joint pain and stiffness that only partially correlates with joint structural damage. Clinically used OA treatments fail to halt disease progression and yield limited pain relief. During the search for new therapies for OA, mesenchymal stem cells (MSCs) …
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The aetiology of pain in chronic midportion Achilles tendinopathy
… and sedentary individuals, which presents as pain and loss of function in the lower limb. Tendon pathology can exist without pain, but the hallmark of the condition is pain, which is classically of insidious onset, related to loading activity and often resistant to treatment. While the biology …
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The relationship between genes associated with the pain pathways and the development of chronic shoulder pain and disability in South African breast cancer survivors
… healthcare is the frequency of chronic shoulder pain and disability among breast cancer survivors (BCS). Compounding this issue is that a significant number of BCS in South Africa are low-income individuals, exacerbating the economic burden associated with managing chronic pain and disability. …
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Temporal Dynamics of Heat Pain Sensations
The moment-to-moment fluctuations in pain-evoked sensory and emotional qualities, and how the pain experience differs between sexes are not well understood. Therefore, this thesis sought to 1) characterise the temporal profiles of the most prominent noxious heat-evoked sensations, 2) characterise …