Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"packaging efficiency"”.
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Investigating the mechanism of RNA packaging in Rift Valley Fever phlebovirus
… recognition and recruitment of viral RNPs for packaging into RVFV particles is valuable for understanding the regulation of virus replication, virus evolution, and genetic reassortment. However, the mechanisms of viral RNA packaging in RVFV and other bunyaviruses are largely unknown. To study …
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Towards Optimising Lentiviral Vectors Through Structure Informed Genome Modification
… elements that drive its expression including the packaging signal (psi). Lentiviral vector particles carry two copies of transfer vector RNA that become linked via a process known as dimerisation. I focused on improving the infectivity of vectors by targeting their dimerisation and packaging …