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Showing 1 to 11 of 11 for “"pVHL"”.
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Μελέτη των μοριακών μηχανισμών ανάπτυξης του οφθαλμικού πτερυγίου στον άνθρωπο : ο ρόλος του μεταγραφικού παράγοντα HIF-1α, της πρωτεΐνης pVHL και των πρωτεΐνών θερμικού σοκ
… συνθήκες οξυγόνου η πρωτεΐνη von Hippel Lindau (pVHL) διατηρεί τα επίπεδα της δραστικότητας του HIF-1α χαμηλά. Επιπλέον, πολλά είναι τα ερευνητικά δεδομένα που αποκαλύπτουν τη συνεργασία των οδών ρύθμισης των επιπέδων του οξυγόνου και της έκφρασης των πρωτεϊνών θερμικού σοκ (Heat shock proteins), …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
… cancer syndrome. The *VHL* protein product, pVHL, is the substrate recognition component of an E3 ubiquitin ligase complex responsible for targeting Hypoxia Inducible Factors (HIFs) for proteasomal degradation. Accumulation of the HIF-2α isoform, in particular, drives renal tumourigenesis. …
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Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases
… Rbx1, Elongin B (EloB), Elongin C (EloC) and pVHL. The structure presents a closed state of full-length Cul2 and a new conformation of Rbx1, thought to be in a trajectory from inactive to active state. The thermodynamic signature of the interaction between Cul2 and pVHL-EloBC (VBC) was …
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The Role of Von Hippel-Lindau Protein in the Glomerulus
… RPGN. The Vhlh gene encodes VHL protein (pVHL, product of the Von Hippel-Lindau gene) that functions as the substrate recognition component of an E3 ubiquitin ligase. Although HIFα subunits are the best characterized substrates for pVHL, additional non-HIF mediated targets have been …
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Cibler la vulnérabilité lysosomale dans le cancer du rein héréditaire comme nouvelle approche thérapeutique
… aussi évalué l’expression et la stabilité de pVHL dans les cellules traitées au STF-62247. La physiologie des lysosomes a été étudiée par immunofluorescence pour LAMP-1 à l’aide de la microscopie confocale, tandis que l’expression de protéines reliées à l’autophagie, les lysosomes et de …
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Caracterización de MYBBP como un nuevo gen supresor de tumores
… que la degradación de MYBBP1A está regulada por pVHL, que se pierde frecuentemente en tumores renales, hemos utilizado líneas celulares de carcinoma renal para estudiar la posible función de MYBBP1A como supresor tumoral. Para estudiar el mecanismo molecular a través del cual MYBBP1A participaría …
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Genetic basis of inherited kidney and related tumours
… a somatic hotspot mutation in RCC and disrupts pVHL-ELOC interaction mimicking the effects of pVHL inactivation on expression of hypoxia response elements. *ELOC* functions as a tumour suppressor gene and chromosome 8 deletion was demonstrated in the RCC tissue from the proband and other …
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Molecular mecanisms involved in the pathogenesis of head and neck paragangliomas
… mostraban silenciamiento o niveles más bajos de pVHL. Esto se observó en HNPGLs con y sin mutación en SDH. A diferencia de los resultados de expresión génica hallados en pHx-HNPGLs con mutaciones en VHL, los tumores con deleción del gen o expresión baja de proteína no presentaban sobre-expresión …
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Regulation of C. elegans behavior and physiology by the hypoxia-response pathway
… E3 ubiquitin ligase complex recognition subunit pVHL. HIF drives transcription of hundreds of targets that promote hypoxia adaptation. Recent work has also described important and broad roles for HIF outside of the traditional hypoxia response, including functions in immunity, oxidative and other …
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Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)
… E3-Ubiquitin-Ligase von-Hippel Lindau Faktor (pVHL) konnte ausgeschlossen werden. Daher sind weitere Studien sind notwendig, um die Ubiquitin-E3-Ligase zu identifizieren, welche für die normoxische Degradation von ATF-4 verantwortlich ist. In weiteren Versuchen konnten durch Untersuchung der …
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Hypoxia regulated pathways in urological malignancies
… expressed in many clear-cell RCCs due to loss of pVHL tumour<br/>suppressor function within the tumour. In vitro, HIF-1 and HIF-2 regulate a differential set of<br/>target genes, although their expression in primary ccRCC clinical samples and their effects on<br/>patient prognosis has yet to be …