Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"pSTAT3"”.
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The Effects of Aging on EGFR/pSTAT3-Dependent Gliovascular Structural Plasticity
Astrocytes comprise the most abundant cell population in human brain (1). First described by Virchow as being 'glue' of the brain (2), modern research has truly extended our knowledge and understanding regarding the vast array of roles these cells execute under normal physiological conditions. …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… kinase 1/2 (ERK1/2) by 80±7% (Lys-lessSOCS3/pSTAT3) and 74±6% (WT/pSTAT3) (n=3, P<0.05) and similarly inhibited PDGF-mediated STAT3 activation but not ERK1/2 by 67±17% (Lys-less SOCS3/pSTAT3) and 72±18% (WT/pSTAT3) (n=3, P<0.05). Functionally, Lys-less SOCS3 and WT were equivalent in …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… kinase 1/2 (ERK1/2) by 80±7% (Lys-lessSOCS3/pSTAT3) and 74±6% (WT/pSTAT3) (n=3, P<0.05) and similarly inhibited PDGF-mediated STAT3 activation but not ERK1/2 by 67±17% (Lys-less SOCS3/pSTAT3) and 72±18% (WT/pSTAT3) (n=3, P<0.05). Functionally, Lys-less SOCS3 and WT were equivalent in …
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Identification of the presence and activity of the JAK-STAT pathway in canine solid tumors
… tumor types, with expression of JAK1, STAT3, and pSTAT3 being highest overall for all tumor types. Significant associations were seen between JAK1 and survival time in MCT (p = 0.03), pJAK1 and survival time in HSA (p = 0.009) and MCT (p = 0.04), and pSTAT3 and metastasis in MCT (p = 0.0008). …
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Regulation of Astrocyte Functions by a Parkinson's Disease Gene, DJ-1
… roles in astrogliosis by regulating of the pSTAT3 signaling pathway for tissue repair after brain injury 27 1. Repair of brain injury was attenuated in DJ-1 KO mice 27 2. DJ-1 deficiency causes a defect of astrogliosis . 30 3. Reduction of astrocyte derived GDNF expression and attenuated …
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Die Rolle von CNTF und LIF bei glialen Reaktionen nach Läsion des Nervus opticus
… zugleich lässt sich nur sehr viel weniger pSTAT3 nachweisen. Auch nach Läsion kommt es, erstens zu keiner so starken Müllerzellaktivierung, zweitens bleibt die STAT3-Aktivierung auf deutlich niedrigerem Niveau. <br>3. Müllerzellen von LIF-defizienten Tieren sind im Phänotyp sowie in der …
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Prognostic role of tumour associated trypsin inhibitor in colorectal cancer patients
… expression and downstream signalling proteins pSTAT3 and pERK1/2, as well as KRAS mutation status. Apart from a significant association between t-TATI expression and KRAS mutation status, there was no intercorrelation between t-TATI or s-TATI and the investigative markers. Expression of pERK1/2 …
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Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model
… androgen signaling (AR) and inflammation (IL-6, pSTAT3-Y705). No effects were observed by lycopene supplementation. Between tumor phenotypes, there was differential expression of genes related to androgen signaling (srd5a1, srd5a2) and angiogenesis (vegfa). In Chapter 3, we hypothesized that a …
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The Mechanism of the Gastric Epithelial Stem Cell Response to Metaplastic Injury
… macrophages. Once induced, CD44 associates with pSTAT3 to increase Cyclin D1 expression and consequent stem/progenitor cell proliferation. In conclusion, this thesis identifies a marker and pathway for the presumptive stem cell of the gastric epithelium during response to atrophy and during …
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Neural Mechanisms of Homeostatic Need and Reward
… of DIO mice which also showed normalization of pSTAT3 levels after rapamycin treatment. Consistent with an effect on POMC neurons, rapamycin did not alter food intake or adiposity in mice after an ablation of POMC neurons or in MC4R knockout mice. In contrast, a POMC-specific deletion of Tsc1, …
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The role of SOCS3 in nuclear reprogramming and naïve pluripotency network integration
Survival and persistence of live matter requires certain flexibility to allow multiple adaptations, yet it is grounded on orderly and stringent regulation of its important functions. An astounding example of natural planning is given by mammalian embryological development where a sophisticated …