Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"pRB"”.
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VALUTAZIONE DI MATERIALI INNOVATIVI PER L ALLESTIMENTO DI BARRIERE REATTIVE PERMEABILI (PRB)
Le barriere reattive permeabili, che rappresentano un mezzo per prevenire e/o annulare l'inquinamento delle falde, sono oggetto di studio e continuo perfezionamento soprattutto per quanto riguarda la natura dei materiali reattivi. Secondo le nuove teorie, il materiale più efficiente è quello che …
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Molecular analysis of the role of E2F proteins in the pRB pathway
… by cell cycle-dependent interactions with the pRB-related proteins p107 and p130. Unlike pRB, mutations in p107 or p130 are not associated with cancer. The different properties of the pRB family may result from the manner in which each protein regulates E2F. To determine how individual E2Fs …
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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
… progression. The retinoblastoma protein (pRB) is the prototypic tumor suppressor. Its tumor suppressive properties are linked to its ability to negatively regulate proliferation by inhibiting E2F target gene transcription. Using a gene targeted mouse model defective for interactions …
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Economic evaluation of burning bituminous and western PRB coals for power production based on select pollution control scenarios
… and western low-sulfur Powder River Basin (PRB) coals at pulverized coal (PC) power plants while meeting the air emission limitations in these regulations. Since power plants are one of the biggest emission sources of carbon dioxide (CO2) – a main greenhouse gas – and thus a target for …
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The role of the retinoblastoma protein in mitochondrial apoptosis
The retinoblastoma protein (pRB) tumor suppressor is deregulated in the vast majority of human tumors. pRB is a well-established transcriptional co-regulator that influences many fundamental cellular processes. It has been most well characterized in its ability to block cell proliferation by …
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Dissecting the molecular role of distinct binding interfaces on the retinoblastoma tumor suppressor in growth control and tumorigenesis.
The retinoblastoma tumor suppressor protein (pRB) functions to maintain proliferative control and act as a barrier to tumorigenesis. pRB is capable of regulating E2F transcription factors to mediate control of proliferation through transcriptional regulation of S-phase target gene expression. In …
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Functional investigation of the role of the retinoblastoma protein in genome stability
… been discovered that the retinoblastoma protein (pRB), typically known for its role in cell cycle regulation, also aids in the maintenance of genome stability. Intriguingly, mutations to the pRB gene, RB1, can arise late in tumorigenesis in cancer cells whose cell cycle regulation is already …
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Design Methodology for Permeable Reactive Barriers Combined With Monitored Natural Attenuation
Permeable reactive barrier (PRB) technology is increasingly considered for in situ treatment of contaminated groundwater; however, current design formulas for PRBs are limited and do not properly account for all major physical and attenuation processes driving remediation. This study focused on …
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The role of E2F4 in the growth suppressive properties of the retinoblastoma protein
… functions of the retinoblastoma protein (pRB), the first identified tumor suppressor, are considerably mediated through the repression of the E2F transcription factors. Functional inactivation of pRB, and subsequent deregulation of E2F activity, is a critical event in the formation of most …
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pRb's role in cell fate, lineage commitment, and tumorigenesis
The product of the retinoblastoma gene, pRB, was the first known and cloned tumor suppressor gene and it is functionally inactivated in most human cancers. pRB is thought to suppresses tumorigenesis by restraining cellular proliferation. pRB binds to the E2F family of transcription factors and …
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Identification of molecular signaling pathways underlying human endometrial stromal cell differentiation
… and progesterone receptor isoforms (PRA and PRB) in human decidualization. Previous studies established that HESC, when treated with the differentiation cocktail containing E, P, and a cyclic adenosine monophosphate (cAMP) analog, cease proliferation and undergo differentiation. In the …
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Microbial Reduction of Perchlorate in Fixed Bed Biofilm Reactors for Water Treatment
… biofilm model describing the competition between PRB and other heterotrophic bacteria and the effect of mass transfer was developed. Parameter estimation was performed using a modified Generalized Likelihood Uncertainty Estimation (GLUE) approach. The model is used to evaluate the influence of …
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Pocket protein family function in mesenchymal tissue development and tumorigenesis
pRB is a member of the pocket protein family, which includes the closely related proteins p107 and p130. The pocket proteins are critical regulators of the cell cycle and function to restrain proliferation by controlling the activity of the E2F family of transcription factors. The pocket proteins …
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Rigenerazione mediante irradiamento a microonde di carboni attivi saturi da contaminanti emergenti
… reattiva permeabile (Permeable reactive barrier, PRB), in cui il materiale reattivo di riempimento più utilizzato sono i carboni attivi. Il nuovo sistema di trattamento proposto nel presente studio prevede l’accoppiamento della PRB con l’irradiamento a microonde per la rigenerazione del GAC …
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The Utility of Foraminifera in Documenting Sediment Provenance for Overwash Deposits: A Case Study Using Sediments Deposited by Tropical Cyclone Pam In Vanuatu
… and a volcaniclastic beach (Port Resolution Bay; PRB). At Manuro, the TC Pam sediments were up to 10 cm thick and contained abundant foraminifera (955 to 2015 individuals per 5 cm<sup>3</sup>). At PRB, TC Pam sediments were up to 44 cm thick with lower abundances of foraminifera (27 to 206 …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
… targets of the retinoblastoma protein (pRB) pathway. A component of the pRB pathway is mutated in most human tumors resulting in deregulation of cell cycle control through the inappropriate release of E2Fs. E2F1, E2F2, and E2F3 are members of the "activating E2F" subfamily that is …
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Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells
… Barbacid 2001). The retinoblastoma protein (pRb), and its homologues pRb2/p130 and p107, comprise a gene family which is central in maintaining appropriate cell proliferation and differentiation. The RB proteins bind to and modulate the activity of E2F transcription factors, by way of a …
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E2F1 induction following DNA damage and oncogene activation
… E2F1, a critical target of the tumour suppressor pRb, is deregulated in most human cancers. Oncogenes have been shown to deregulate E2F1 through inhibition of pRB and deregulation of E2F1 is an event that occurs in most human cancers. The essential role of E2F1 in apoptosis is well documented and …
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Determining the endometrial phenotype of women with abnormal uterine bleeding
… assessed sex steroid receptors: PR, PRB, ESR, AR and candidate progesterone-regulated genes (FOXO1, HAND2, IL15, IGFBP1, HOXA10, 17ßHSD2 and FOXM1). Immunohistochemistry evaluated spatiotemporal immunolocalisation, on a selection of samples, of sex steroid receptors (PR, PRB, ERα, AR) …
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