Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"pMHC"”.
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Type B Presentation from HEL Protein in the Context of Inflammation
… where multiple conformations of a given pMHC pair are allowed, generating both type A and B pMHC complexes. Protein traffics to the late endosomal compartment and is loaded onto nascent MHC II in the presence of the editor H2-DM where type A pMHC conformers are selectively formed, …
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Primary mental healthcare for older people in India: an analysis of policies and stakeholder interviews
… practice. Although primary mental healthcare (PMHC) approaches are particularly important for old age-inclusive and equitable approaches to mental healthcare, there is a lack of understanding of how the mental health needs of older people can be addressed in policies and practice. An in-depth …
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Understanding the effects of higher order sequence features on peptide MHC binding
… the factors that contribute to peptide-MHC (pMHC) affinity is critical for the study of immune responses and the development of novel therapeutics. In this thesis we propose the use of sequence feature representations as a means of capturing and categorizing these factors, and we develop the …
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Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands
… major histocompatibility complex (MHC) molecule (pMHC), which differ by as few as only one amino acid, and trigger different T cell responses. When T cell signaling was suppressed, TCR had similar affinity and kinetics for agonist and antagonist pMHC whose binding to CD8 was undetectable. TCR on …
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Combined experimental and modeling studies reveal new mechanisms in T cell antigen recognition
… loaded onto Major Histocompatibility Complex (pMHC) molecules through their T Cell Receptor (TCR). The recognition of antigenic pMHC by the TCR is an extremely sensitive and specific process, discriminating as few as a single antigenic pMHC from the self majority while remaining tolerant to …
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Recognition of hepatitis B epitopes by T cell receptors and T cell receptor-like antibodies
… recognize these viral peptide-MHC complexes (pMHC) can become activated and destroy the virus-infected cell. However, the immune system of many patients with chronic viruses has undergone a process of tolerance whereby the T cells are either non-existent or inactive. The ability to study the …
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High-throughput tools for decoding T cell receptor specificity
… presented by major histocompatibility complex (pMHC) proteins, driving immune responses in cancer, infection, and autoimmunity. Understanding how TCRs recognize antigens is crucial for developing cancer immunotherapies and identifying therapeutic targets in autoimmunity, infectious disease, and …
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Knowledge, attitudes and practices of health professionals in management of pain in aids patients at Polokwane/ Mankweng Hospital complex, Limpopo Province
… at Polokwane/Mankweng Hospital Complex (PMHC). This is the first part of the project, which involved a baseline study to assess the knowledge, attitude and practice of doctors working in the two hospitals in managing pain in HIV/AIDS patients. Admissions due to the AIDS epidemic have …
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Expanding Allergen-specific Tr-1 CD4+ T cells to treat Allergic Asthma
… of asthma in BALB/c mice, and found that the pMHC-NP therapy triggers allergen-specific Tr-1 cell formation and expansion that can suppress inflammation, promoting the resolution of airways hyper-responsiveness and airway remodeling. Asthma-relevant pMHC class II-coated NPs may therefore …
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The dependence of CD4 T cell development and activation on the kinetics of the TCR:pMHC interaction
… k<sub>on</sub>) between the TCR and the pMHC. The overall affinity of the complex must be sufficient for productive transmission of signals through the TCR to activate a T cell. However, the precise regulation of this event is not fully understood. Structural changes are thought to occur …
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The mechanobiology of the T-Cell Receptor: Structurally connecting catch bonds with ligand binding and triggering
… peptide-loaded major histocompatibility complex (pMHC) can be predicted a priori by using "in silico" biology and that catch bonds are required to effectively recognize epitopes. TCRs must rotate around the pMHC binding axes to form catch bonds and thus induce functional conformational states of …
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Stochastic and spatiotemporal effects in T-cell signaling
… cell receptors (TCR) and peptide-MHC complexes (pMHC), the second on the equilibrium affinity (KD). We study an extensive set of TCR-pMHC interactions in CD4+ T cells which have differential KD and kinetics of binding. The data indicate that ligands with short t1/2 can be highly stimulatory if …
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Visualizing Dendritic Cells In Vivo
… role of TCR affinity for MHC:peptide complexes (pMHC) in these interactions during tolerance induction. We observed that pMHC potency correlates with T cell proliferation, Ca<sup>2+</sup> flux and with early antigenspecific arrest; T cell anergy was induced by all ligands that activated T cells, …
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Binding, Thermodynamic and Structural Studies of High-Affinity T Cell Receptor-Peptide MHC Interactions
… may be useful in future studies of TCR-pMHC binding interactions.
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Engineering the T Cell Receptor to Protect Host Cells in Superantigen-Induced Septic Shock
… a class II major histocompatability complex (pMHC) product on the host cell surface, thus circumventing the normal recognition of intracellularly-processed antigens. Because SAgs can bind to many different TCRs, SAg engagement of T cells leads to polyclonal expansion of up to 20% of all T …
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The Initial Events of T-Cell Activation in Realistic Model Systems
… within the major histocompatibility complex (pMHC) on the surface of antigen presenting cells (APCs). Therefore, T-cell activation is crucially cell-cell contact dependent. The exact molecular mechanism that allows T cells to detect antigens with unprecedented selectivity and sensitivity …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… We identified allostimulatory peptide-MHC (pMHC) ligands (I-E<super>k</super> as the allogeneic MHC) for two LLO/I-A<super>b</super>-specific CD4+ T cells, LLO118 and 1G5.1. Both T cells recognized their allostimulatory ligand with a high degree of specificity and sensitivity for the …
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Expanding Antigen-specific Tr1 Cells to Treat Autoimmunity
… with disease-inducing epitopes. EAE-relevant pMHC II-NPs were not only effective in suppressing inflammation but also in promoting re-myelination. Thus this therapy provides a negative feedback loop that serves to counter autoimmune disease progression.
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Antigen Recognition by an Alloreactive T Lymphocyte Clone
… which improve the affinity of the TCR for pMHC. Finally, in chapter six we have examined the ability of 2C TCR transgenic mice on a RAG knockout background to recognize and eliminate tumors bearing the L$\sp{\rm d}$ alloantigen. We show that tumor rejection in this system occurs independent …
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Cell surface display in biomedical applications and biofuels production
… A virus genome. The production of peptide-MHC (pMHC) tetramer, especially class II pMHC tetramer, is very time-consuming and labor-intensive and often show low avidity, thus represents another challenge in the biomedical research area. To address these limitations, we sought to engineer MHC …
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