Global ETD Search
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Showing 1 to 8 of 8 for “"pLGIC"”.
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Computational modeling and simulation of ligand-gated ion channels
The pentameric ligand-gated ion channel (pLGIC) superfamily, from bacteria to the brain, convert chemical signals into electric signals. These proteins are composed of two distinct domains; the extracellular domain (ECD), where the chemical compounds (ligands) bind, and the transmembrane domain …
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The Lipid-Facing M4 Helix of α4β2 nACh and 5-HT3A Receptors
Pentameric ligand-gated ion channels (pLGICs) are expressed throughout the human nervous system, and contribute to a range of muscle, gut, and neurological functions. Elucidating their mechanism of action and how it might be modulated would improve our understanding of the nervous system, and …
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The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
… junction. Extensive studies on the prototypic pLGIC, the Torpedo nicotinic acetylcholine receptor (nAChR) have revealed an exquisite lipid sensitivity, with the nAChR adopting a novel uncoupled conformation in membranes lacking activating anionic and neutral lipids. The lipid-exposed …
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The emerging role of the a4(+)a4(-) interface as a determinant of functional signatures of a4ß2 nicotinic acetylcholine receptors
… pentameric ligand-gated ion channels (pLGIC), a4p2 receptors are activated by binding of agonist to sites located at the a4( + )/P2( -) interfaces. These interfaces are present in both stoichiometries they are unlikely to contain structural differences conferring specific properties to …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
… in the pentameric ligand gated ion channel (pLGIC) family. In addition, the effector system for the potentiating effects of dFBr was also identified. The post-M4 region (C-terminal) and the Cys loop residues F167 and F170 of the α4 subunit play central roles in transducing dFBr binding to …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
… in the pentameric ligand gated ion channel (pLGIC) family. In addition the effector system for the potentiating effects of dFBr was also identified. The post-M4 region (C-termina1) and the Cys loop residues FI 67 and F170 of the a4 subunit play central roles in transducing dFBr binding to …
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Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
Pentameric ligand-gated ion channels (pLGICs) are a superfamily of neurotransmitter-gated ion channels, that includes (in vertebrates) the nicotinic Acetylcholine Receptor (AChR), Serotonin Receptor type 3 (5-HT3R), γ-Aminobutyric acid Receptor type A (GABAAR), and the Glycine Receptor (GlyR). All …
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Developing Antibody Tools against Glycine Receptors
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