Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"pKd"”.
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Untersuchungen zum Mechanismus der PKD-vermittelten EGF Rezeptor-Transmodulation
… einer dominant negativen Mutante der Effekt von PKD auf diesen Prozess nachgewiesen und ihre Rolle in der bereits durch (Bagowski et al., 1999) beschriebenen PDGF-vermittelten JNK-Inhibition verifiziert. Weiterhin wurde gezeigt, dass die Liganden Endothelin und LPA, die ihre Signale über …
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Exploring the Role of PKD Enzymes in the Innate and Adaptive cells of the Mammalian Immune System
Protein kinase D (PKD) enzymes are a family of serine/threonine kinases that belong to the calcium/calmodulin-dependent kinase superfamily. Recently, a role for PKD enzymes has been established in the adaptive immune system where murine PKD2 was shown to be essential for normal peripheral CD4+ and …
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Heart in Polycystic Kidney Disease is Characterized by Cardiac Dysfunction and Structural Deformation
… Autosomal dominant polycystic kidney disease (PKD) is a hereditary disorder affecting multiple organs, including the heart. PKD patients have been associated with arrhythmogenic remodeling in some clinical evaluations. However, the structural changes in myocardium and pathway analyses on the …
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Leveraging cellular models of polycystic kidney disease for mechanistic discovery and therapeutic development
Polycystic kidney disease (PKD) is a life-threatening disorder characterized by the progressive expansion of fluid-filled cysts originating from kidney tubules. As the leading monogenic cause of renal failure, PKD affects 1 in ~1,000 people with 50% of patients meeting criteria for end-stage renal …
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Investigating Feeding Omega-3 Polyunsaturated Fatty Acids and/or Soy Protein Isolate to Female pck Rats on Polycystic Kidney Disease and Related Complications
Polycystic kidney disease (PKD) is a genetic disorder characterized by multiple benign cysts along the epithelial lining of the kidneys. As PKD progresses, cyst growth increases kidney volume, decreases renal function, and may eventually lead to end stage renal disease. In addition to renal …
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The nanomechanics of polycystin-1: A kidney mechanosensor
… Autosomal Dominant Polycystic Kidney Disease (ADPKD), which is a leading cause of renal failure. The available evidence suggests that PC1 acts as a mechanosensor, receiving signals from the primary cilia, neighboring cells, and extracellular matrix. PC1 is a large membrane protein that has a long …
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Targeting Glutamine Metabolism in Kidney Development and Polycystic Kidney Disease
… renal failure. While the primary causes of PKD are genetic mutations in one of the polycystins that encode the PKD1 and PKD2 proteins, the age of onset and severity of PKD cases greatly varies, suggesting other genes/processes are involved. Lkb1 is a serine-threonine kinase involved in the …
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Development of Therapies to Treat Polycystic Kidney Disease
Polycystic kidney diseases (PKD) are genetic disorders characterized by fluid filled cysts in the kidney tubules and liver bile ducts. There are two forms of PKD, autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD). The focus of the studies …
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Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
… interested in the spatiotemporal activation of PKD and its functional role in regulation of HDAC5 translocation. HDAC5 is a transcriptional repressor whose dynamic shuttling between the nucleus and the cytosol determines the outcome of transcriptional control for MEF2-dependent genes. I use a …
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The Roles of Primary Cilia in Cardiovascular Diseases and Cancer
… cancer, ciliopathies polycystic kidney disease (PKD, liver disorders, mental retardation, and obesity to cardiovascular diseases. Dysfunction in endothelial cilia contributes to aberrant fluid-sensing and results in vascular disorders, such as hypertension, aneurysm, and atherosclerosis. In this …
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Molecular diagnosis in inherited polycystic kidney disease
Polycystic Kidney Disease (PKD) incorporates a number of genetically but not always phenotypically distinct inherited cystic kidney disorders. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most frequent, with an estimated prevalence of 1:1000. Though common, there are numerous …
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Targeting Primary Cilia Immune Receptor Proteins for the Treatment of Polycystic Kidney Disease Mechanisms
… the progression of polycystic kidney disease (PKD) which further leads to the inflammatory responses. We, therefore, investigated the role of Toll-like receptors 4 and 9 (TLR) in primary cilia towards PKD.</p> <p><strong>Purpose: </strong>The main purpose of the proposed study is to identify …
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The effect of mechanical vestibular stimulation on muscle tone and spasticity in individuals with neurological impairment
… (Biceps Femoris) muscles along with the PKD test. The activation of EMG during PKD can be understood in relationship to the flexion and extension of the lower leg. It is interesting that EMG activity for quadriceps is seen at every flexion cycle in the post stimulation data, while on the …
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Mutation detection for genotype/phenotype correlation studies in autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders (Gabow, 1993), with an estimated prevalence of 1 in 400 to 1 in 1000 (Dalgaard, 1957; Gabow, 1993). The disease is the fourth leading cause of renal failure with more than 10 million people affected …
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Engineering Complex Kidney Structures for Disease Modelling, Drug Testing, and Studying Kidney Development
… To model polycystic kidney disease (PKD), we pharmacologically induced cyst formation within engineered tubules. Next, we tested and quantified different compounds’ effect on cyst regression, identifying new potential pharmacological treatment; we showed that 2-deoxy-D-glucose is more …
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Can we predict when to start renal replacement therapy in chronic kidney disease patient by using 6 months clinical data?
… mellitus (DM), Polycystic kidney disease (PKD), serum albumin, serum hemoglobin, serum calcium, serum phosphorus, serum potassium, eGFR (MDRD), and urine protein) were included final risk prediction model (R2 = 0.403). The calculated risk index(RI) was –0.011 x age – 0.468 x albumin - 0.069 …
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Health Care Resource Utilization and Expenditures in Persons with Autosomal Dominant Polycystic Kidney Disease
… autosomal dominant polycystic kidney disease (ADPKD), to determine all-cause health care resource utilization and all-cause health care expenditures, to determine incremental health care resource utilization, and to determine incremental health care expenditures associated with ADPKD. An …
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Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
… Kinase C: nPKC) activates Protein Kinase D: PKD) to directly phosphorylate Par-1b on serine 400: S400), a residue that is conserved in all four mammalian Par-1 kinases as well as the fly ortholog. Phosphorylation of Par-1b on T595 and S400 causes Par-1b to relocate from membranes to the …
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Protein kinases that phosphorylate 14-3-3 isoforms
… in an isoform specific manner, for example SDK1 /PKD phosphorylates 14 -3 -3 11,13 and (, but not cs and T. Our laboratory has previously identified in vivo 14 -3 -3 phosphorylation sites, S185 and S233. Phosphorylation of S233 by the serine /threonine protein kinase Casein kinase la (CK1 a) was …
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Transforming growth factor beta 1 : Role in the progression of chronic renal failure.
… in patients with primary nephropathy (excluding PKD). Genotype at codon 25 was also associated with severity of proteinuria (p= 0.038), plasma TGF-B1 protein levels (p = 0,01), and the severity of glomerulosclerosis (p<0.05). Genotype at C-509T was associated with the level of renal tubular …
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