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Showing 1 to 2 of 2 for “"pKa shift"”.
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Novel In-Vitro Approaches to Investigate Membrane Partitioning and pH-Dependent Passive Permeation of Small Molecule Drugs
… the acid/base nature and ionization constant (pKa) are very important for predicting their passive permeation across biological barriers. Depending on the pKa of ionizable groups, drug molecules may coexist in various biological fluids both their charged and uncharged forms to varying extents. …
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The Effects of Buried Ionizable Amino Acids on the Stability of Ribonuclease Sa
… pK of buried ionizable mutant side chains are shifted, there is an apparent positive correlation between the magnitude of the pK shift and the magnitude of the change in stability. Thus, the buried ionizable mutants that are the least likely to be charged at physiological pH were observed to …