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Showing 1 to 10 of 10 for “"pIKK"”.
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PIKK-dependent activation of the DNA damage response by long wavelength ultraviolet radiation
Ultraviolet radiation (UV) is one of the main risk factors that increase a person’s chance of developing skin cancer. UV is divided into three subtypes, called UVA, UVB and UVC. UVA and UVB both have the ability to cause different types of DNA damage. Our understanding of UVA and its mechanism of …
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Cell cycle checkpoints and checkpoint kinases in the apicomplexan parasites Plasmodium and Toxoplasma
… Phosphatidylinositol 3-kinase-related kinases (PIKKs) are responsible for checkpoint control in model eukaryotes. Members of this protein family are missing in *Plasmodium*, but some remain in the close relative *Toxoplasma gondii*. A suite of experiments were conducted to investigate these …
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Identifying a role for Ciz1 in the DNA damage response
… 3-kinase-like protein kinases (PIKKs), which propagate DDR signalling by phosphorylating SQ/TQ motifs in substrate proteins. Ciz1 is a vertebrate protein previously shown to stimulate DNA replication initiation and facilitate cyclin exchange at pre-replication complexes. Ciz1 …
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Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis
… like serine/threonine kinases (PIKK) that collectively regulate the DDR network. Studies have demonstrated these kinases can phosphorylate many of the same substrates, suggesting a significant potential for functional redundancy. However, deficiencies in these kinases have been …
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Study of the segregation mechanism of the Bovine Papillomavirus Type 1
… E2 valgu juuresolekul olid võimelised rakkudes pikk aega säilima. See töö näitas, et PV vaikolekut tagav element on funktsionaalne ka koos teistest viirustest pärit elementidega. Praeguseks on selle töö tulemused ka patenteeritud ning leidnud tööstuslikku kasutamist. Väga paljud maailmas …
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The interaction of CtIP with DNA damage response proteins
… RPA70, signal transducer proteins such as the PIKK kinases ATM, ATR and SMG1 and the mediator proteins 53BP1 and MDC1. All of those proteins are involved in detecting and repairing double stranded or single stranded lesions. Moreover CtIP has a major influence on phosphorylation events induced …
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DNA damage responses in the context of the cell division cycle
… I show the identification of a consensus ‘SQ’ PIKK phosphorylation motif at the carboxyl end of the GINS complex subunit, Psf1. In Saccharomyces cerevisiae, switching the conserved serine to a glutamic acid is lethal, indicating that the site is crucial for the protein’s function. Moreover, in …
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Double-Strand Break Repair Mechanisms in Human Embryonic Stem Cells
… phosphatidyl-inositol-3’-kinase-related kinase (PIKK) family, including Ataxia Telangiectasia Mutated (ATM), Ataxia Telangiectasia Mutated and Rad3-related (ATR) and the DNA dependent protein kinase (DNA-PK). The aim of this study was to define the mechanisms and important proteins involved in …
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A Novel Phosphorylation Site in the Telomeric Protein TRF2 is Regulated by the ATR Kinase and Plays a Role in Relieving Replication Stress at the Telomere
<p>Phosphatidyl inositol 3-kinase-like kinases (PIKKs) have a well documented function at yeast telomeres. Although several lines of evidence suggest that members of the PIKK family also play a role in vertebrate telomere biology, little is known about their specific functions. We report that the …