Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"pH-sensitive liposomes"”.
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Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane
<p>As a promising pH-triggerable molecular switch, trans -2-aminocyclohexanol (TACH) has a variety of applications. By introducing two hydrocarbon tails, multiple TACH-based lipids (flipids) have been designed and studied that are able to perform a drastic conformational flip upon protonation, …
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Zelluläre Aufnahme und intrazelluläres Schicksal von partikulären Drug Delivery Systemen
… für die partikuläre Aufnahme in die Zelle, wie Phagocytose, Makropinocytose, Caveolae-vermittelte Endozytose und so genannte Non-Clathrin-non-Caveolae vermittelte Endozytose. Von diesen Wegen erscheint die Internalisierung mittels Caveolae besonders viel versprechend für ein gezieltes Drug …
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Development of Afatinib lipid nanoparticles targeting non small cell lung cancer
… therapeutic nanotechnologies. In this study, a sensitive and selective HPLC method was developed for the quantification of afatinib (AFT) in formulations. Novel drug delivery systems based on cationic (CL) and pH-sensitive liposomes (PSL) for AFT were developed, with different ratios of lipid to …
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Investigation of a fusogenic pH-sensitive liposomal system for tumour-targeted intracellular delivery of dinitrobenzamide mustard prodrugs
… characteristic of solid tumours, such as low pH, hypoxia and the leaky vasculature, may be exploited as triggers to improve therapeutic outcomes. Dinitrobenzamide mustard (DNBM) prodrugs, designed to be selectively activated under tumour hypoxia, were developed as a pharmacological approach …