Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 62 for “"pH-responsive"”.
-
PH-responsive polymeric materials for encapsulation and triggered release
… these challenges, scientists look to stimuli-responsive polymers as a solution because polymers can be designed with tailored properties thanks to advancement in polymer chemistry and engineering. This dissertation discloses a collaborative effort between the Zimmerman group and Dow Chemical …
-
Synthesis and rheology of pH-responsive particles with shape anisotropy
… produce large quantities of shape anisotropic, amphoteric particles in a size range of about 1 µm. Two different kinds of shape anisotropic particles are prepared for comparison to study the effects of incorporating pH-responsive groups on the properties of suspensions containing shape anisotropic …
-
Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles
… on the RAFT polymerization of a family of amphiphilic, cationic copolymers to be utilized for nucleic acid delivery. These copolymers are composed of a stabilizing hydrophilic block of oligo(ethylene glycol) methyl ether methacrylate (OEMGA) and a cationic, endosomolytic block of …
-
The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications
… to understand the structure of biocompatible pH responsive polymers and their interaction with the biological system in order to design more effective entities for biomedical applications. A systemic approach was used to study the structure and biological interaction of pH responsive …
-
pH-Responsive Polymers for Biosurfaces: An Investigation of Solution Properties and Surface Modifying Performance
… and adhesion was greater in solutions of higher pH, where greater charge density along the polymer backbone was expected. For films prepared via spin-coating onto mica surfaces, addition of surfactants to the solution resulted in film surfaces with more regular morphology and surface coverage. …
-
Development of Soft-Matter Delivery Systems: Coupling pH Responsive Polymers to Porous Silica Particles
… synthesized and characterized a unique dual hydrophilic pH responsive diblock copolymer, PEO-PAA. This hybrid polymeric-nanoparticle system drastically improves targeting and release capabilities through the modular ability to couple multiple different polymers. Furthermore, this work is supported …
-
Synthesis of pH-responsive core-shell nanoparticles of different sizes and with different shell compositions
The endosome-disrupting and pH-responsive poly(2-diethylamino ethyl methacrylate)-core/poly(2- aminoethyl methacrylate)-shell nanoparticles could potentially increase the efficacy of transcutaneous administered vaccines and facilitate the cytosolic delivery of a wide variety of therapeutic …
-
A technical and economic evaluation of novel pH-responsive core-shell nanoparticles : delivering innovation from laboratory to market
… of the Irvine laboratory have developed a novel pH-responsive core-shell nanoparticle system that can achieve efficient and non-cytotoxic drug delivery into the cytosol. Another advantage is that the shell can be easily modified to bind to different types of drug agents and incorporate ligands …
-
Synthesis and study of the micellization behavior of a dual temperature- and pH-responsive PAA-b-PNIPAM block copolymer
<p>Amphiphilic diblock copolymers are composed of hydrophilic and hydrophobic regions. When they are exposed to water, the hydrophobic blocks aggregate to form a hydrophobic core surrounded by hydrophilic regions outside to give a core-shell micelle. These micelles have many potential applications, …
-
Surface plasmon resonance study of the purple gold (AuAl₂) intermetallic, pH-responsive fluorescence gold nanoparticles, and gold nanosphere assembly
… emission of rhodamine green 110 fluorophores from Au NPs with tunable spacers. These spacers consist of polyelectrolyte multilayers (PEMs) consisting of poly(allylamine hydrochloride) and poly(styrene sulfonate) assembled at pH 8.4. The distance between Au NPs and fluorophores was …
-
Functional analyses of ζ-crystallin binding to the 3'-UTR of glutaminase (GA) mRNA
… of the GA mRNA. LLC-PK1- FBPase+ cells, a pH-responsive porcine kidney cell line, express four distinct GA mRNAs, that are ~2.5, 3.5, 4.5, and 5.0 kb in length. RNase H mapping indicated that three of the GA mRNAs are generated by the use of alternative polyadenylation sites and they are …
-
Synthesis of Polysaccharide-based Biomaterials for Drug Delivery
… for polysaccharide-protein conjugates, pH-responsive hydrogels, and amorphous solid dispersion (ASD) polymers were developed. Conjugating a polysaccharide to a protein drug via a covalent bond may improve its medical properties including solubility, stability, immunogenicity, circulation …
-
PH-gated porosity and reversible swelling transitions in polyelectrolyte multilayers
This thesis explores the design of novel pH-responsive polyelectrolyte multilayer (PEM) films. The discoveries of discontinuous pH-induced swelling transitions and concomitant conformational memory effects as well as pH-gated nano- and microporosity in PEMs, are described. The PEMs in this thesis …
-
Hydrogels for Biomacromolecule Immobilization and Sensing
… thesis centers on the development of stimuli-responsive hydrogels that have utility for pH-responsive valves, biomacromolecule sensing, irreversible biomacromolecule immobilization, and reversible biomacromolecule immobilization. Each system discussed has its function derived from a novel …
-
Polymer Dispersity Affects Conformation of Brushes Grafted on Nanoparticles
… partly due to uniform dispersion and/or morphology of polymer brushes with varying chain conformation. Polymer brush properties, such as grafting density \sigma and degree of polymerization N, can drastically affect conformation of neutral and pH-responsive PGNPs and further influence their …
-
Synthesis, physico-chemical properties and potential applications of colloidal gel particles
… solid surfaces to produce new environmental responsive surfaces. The mass of microgel particles deposited on glass pre-treated with acid, glass pre-treated with base, quartz, stainless steel, gold and Teflon at 25°C and 60°C was determined using fluorescence spectroscopy. The factors …
-
Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
… First, a novel acid-labile liquid polymer responsive to endogenous pH conditions was synthesized and characterized for releasing poorly soluble drugs as an injectable depot, a photo-crosslinked implantable matrix, temporarily stable nanodroplets and stable nanogels. Second, two acid-labile …
Page 1 of 4