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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"pH sensitive"”.
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pH-sensitive core-shell nanoparticles for intracellular drug delivery
… can only be taken up by cells via endocytosis or phagocytosis. Such drug molecules are thus confined in endolysosomes, where reduced pH and degradative enzymes may destroy them without therapeutic gain. Efficient escape of drug molecules to the cytosol before destruction in endolysosomes is a …
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An Ultra-pH-Sensitive Logic Decodes Cancer Imaging and Immunotherapy
Pages 186-213 are misnumbered as pages 219-246.
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Trans-2-aminocyclohexanol as a pH-sensitive conformation switch in liposomes
<p>Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads specifically at the low-pH target sites, such as in solid tumors, tissues with inflammation, and ischemia sites. Also, it helps drug/gene to escape endosome trapping and followed lysosome …
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Surface engineering using layer-by-layer assembly of pH-sensitive polymers and nanoparticles
… achieved by using layer-by-layer assembly of pH-sensitive polymers and nanoparticles. In the first part of this thesis, hydrogen-bonded multilayer coatings comprising poly(acrylic acid) and polyacrylamide were used to functionalize spherical colloidal particles. Multilayer-modified colloids …
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Poly ([beta]-amino ester)s as pH sensitive biomaterials for microparticulate genetic vaccine delivery
… particles protect their payload and target it to phagocytic, antigen-presenting immune cells. However, the biomaterial conventionally used in these microparticle formulations, an FDA-approved polyester called poly lactic-co-glycolic acid (PLGA), was not designed specifically to deliver DNA, takes …
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Molecular-thermodynamic theories of micellization of multicomponent surfactant mixtures and of pH-sensitive surfactants
… mixtures, and (2) the micellization of pH-sensitive (or amphoteric) surfactants. Surfactant formulations of practical utility typically consist of many surfactant components. In many practical applications, pH-sensitive surfactants are added as a secondary surfactant because they enhance …
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pH-sensitive resist materials for combined photolithographic patterning of proteins and fluid lipid bilayers
Photolithography of a pH-sensitive photoresist polymer was performed to pattern both lipid bilayers and proteins onto the same surface. The motivation behind this was to create a substrate mimicking an array of antigen- presenting cells. The substrate would consist of signaling ligand, biotin anti- …
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Design and development of stimuli-responsive materials: pH sensitive polymersomes and poly(olefin sulfone)s
… development in areas such as encapsulation, photoresists, sensors, self-healing materials, drug delivery, and transient electronic devices. A variety of chemical triggers can be employed to stimulate materials, for this work the focus has been on pH-responsive materials. Materials which can …
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Investigation of a fusogenic pH-sensitive liposomal system for tumour-targeted intracellular delivery of dinitrobenzamide mustard prodrugs
… characteristic of solid tumours, such as low pH, hypoxia and the leaky vasculature, may be exploited as triggers to improve therapeutic outcomes. Dinitrobenzamide mustard (DNBM) prodrugs, designed to be selectively activated under tumour hypoxia, were developed as a pharmacological approach …
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Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane
<p>As a promising pH-triggerable molecular switch, trans -2-aminocyclohexanol (TACH) has a variety of applications. By introducing two hydrocarbon tails, multiple TACH-based lipids (flipids) have been designed and studied that are able to perform a drastic conformational flip upon protonation, …
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Analysis of stimuli responsive molecules: exploring pH-sensitive acid generators and redox-active molecules for electrochemical CO2 capture
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Increased Utility of pH Sensitive Indicators as High Concentration CO2 Detectors Through the Use of Polyelectrolyte Complexes as Stabilizing Media
… dioxide (CO<sub>2</sub>) which can lower the pH of the packaging environment. This is similar to the CO<sub>2</sub> chemistry responsible for ocean acidification.<sup>3</sup> Dye molecules that are sensitive to environmental changes in pH (known as pH indicators) can be encapsulated in …
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Miniaturized Magnetostrictive Antennas for Wireless Sensing Applications
… MES antennas down to sub-mm sizes from the amorphous magnetostricive film Metglas 2826 MB and their advantages and disadvantages have been studied. Laser micromachining is shown to be a more versatile method compared to fabrication using Diesaw to fabricate antennas of different shapes easily. …
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Studies on the Proton Pumping Mechanism of Aa(3)-Type Cytochrome C Oxidase
… the F-to-O transition. Absorption change of the pH sensitive dye was monitored spectroscopically. Rapid proton release followed by slow proton uptake was observed. This result indicates that both the pumped protons and the protons required for chemistry at the active site might come from an …
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Development, manufacture and application of a solid-state pH sensor using ruthenium oxide
The measurement of pH is undertaken frequently in numerous settings for many applications. The common glass pH probe is almost ideal for measuring pH, and as such, it is used almost ubiquitously. However, glass is not ideal for all applications due to its relatively large size, fragility, need for …
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EXPANDING APPLICATIONS OF IRON OXIDE NANOPARTICLES BY SURFACE FUCNTIONALIZATION: FROM MAGNETIC RESONANCE IMAGING TO NANO-CATALYSIS
… onto SPION surfaces via this approach to develop pH-sensitive MRI contrast agents, specific-DNA MR probes and a biomimetic hydrolysis catalyst. Dendron-SPION conjugates (G1 to G3) have good aqueous solubilities and high transverse relaxivities (>300 s-1*mM-1). They also showed interesting strong …
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Drug Delivery to Solid Tumors via Polymeric Nanoparticles
… and be retained there. Currently, the phagocytic clearance of NPs is avoided by coating NP surface with Polyethylene glycol (PEG). Although successful in prolonging NPs circulation, PEG prevents proper interaction of NPs with the target cells, known as “PEG dilemma”. Low molecular …
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Zelluläre Aufnahme und intrazelluläres Schicksal von partikulären Drug Delivery Systemen
… für die partikuläre Aufnahme in die Zelle, wie Phagocytose, Makropinocytose, Caveolae-vermittelte Endozytose und so genannte Non-Clathrin-non-Caveolae vermittelte Endozytose. Von diesen Wegen erscheint die Internalisierung mittels Caveolae besonders viel versprechend für ein gezieltes Drug …
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Design, fabrication, and application of stimuli-responsive hydrogel actuators
… (BZ) gels. Then, inspired by the photosensitizing capability of Ru(bpy)32+ from the first project, we successfully used visible light to trigger macroscopic movements of polyacrylic acid (PAA) based pH sensitive hydrogels through a photo catalytic water-splitting reaction system, …
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