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Showing 1 to 12 of 12 for “"pH homeostasis"”.
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Examining the effect of anti-tumor lipid drugs on pH homeostasis and membrane structure in Saccharomyces cerevisiae
The lysophosphatidylcholine analogue, edelfosine is a potent anti-tumor lipid drug that is known to target cellular membranes. The underlying mechanisms leading to cell death remain largely controversial, although previous results obtained using yeast, have indicated that edelfosine associates with …
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Characterization of The Ato Gene Family In Alternative Carbon Metabolism
… of immunocompromised individuals. Macrophages are important innate immune cells that limit the niches in the human body in which <em>C. albicans </em>can persist through phagocytic removal. However, following phagocytosis <em>C. albicans</em> readily escapes from the immune cell by …
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Biological studies of organellar (Na⁺,K⁺)/H⁺ exchanger NHE7
Cellular pH homeostasis plays crucial roles in cellular functions, and it is now widely recognized that Na⁺/H⁺ exchangers are among the most prominent players in this process. Although recently described mammalian Na⁺/H⁺ exchanger NHE7 has attracted much attention, its biological functions remain …
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The role of respiration-dependent proton translocation in the acid tolerance of Gluconobacter oxydans
… cells were exposed to 0.1 M or 0.5 !vt NaCI at pH 3.20; subsequent alkalinization of the suspending solution suggested a NaCl-dependent flow of protons (H+) into the cells. Cells were then exposed to NaCI at pH 3.20 followed by the addition of glycerol to determine whether polyol oxidation …
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Engineering Hv1 Channel Mutations and Targeted Drug for Treatment of Hv1 Mutation Associated with Cancer
… channel Hv1 is crucial for maintaining cellular pH homeostasis by regulating proton movement across membranes, playing a vital role in acid extrusion and intracellular pH regulation. Dysregulation of Hv1 is associated with various diseases, including cancer, where it helps maintain an acidic …
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Theoretical and computational investigations into structure-function relationships of biomolecular machines at atomic resolution
… protein secretion and maintenance of pH homeostasis. Despite intense research efforts, the atomic-level mechanism transmitting other form of energy into mechanical force is still unclear. Molecular dynamics simulations, though capable of providing atomic details, are limited in the …
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Protein expression in Fusobacterium nucleatum ATCC 10953 biofilm cells induced by an alkaline environment.
… favour the growth of the organism. One of the physico-chemical changes that occurs in the diseased periodontal sulcus is an increased environmental pH, which may be as high as 8.5. In our laboratory, F. nucleatum subspecies polymorphum ATCC 10953 formed mono-culture biofilms at pH 8.2. The …
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Ion-regulatory proreins in neuronal development and communication
… function is critically dependent on the ionic homeostasis in both the extra- and intracellular compartment. The regulation of brain extracellular ionic composition mainly relies on active transport at blood brain and at blood cerebrospinal fluid interfaces whereas intracellular ion regulation …
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Recovery of rare earth elements (REE) from waste printed circuit boards (WPCBs) through heterotrophic bioleaching
… strains (e.g. Aspergillus niger) in the heterotrophic bioleaching of REE from WPCBs. Adjusting initial pH (7.5), providing low phosphate concentrations (0.1 mM), and excluding the use of a buffering agent in the bioleaching medium were identified as the most effective factors for maximizing …
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Transcriptomic characterization of soybean – sclerotinia sclerotiorum interaction at early infection stages
… programmed cell death (PCD) and autophagy was detected as a common reaction in both genotypes. It is speculated that, because S. sclerotiorum is a necrotrophic fungus that feeds on dead host cells, inhibiting host cell death could slow down its infection. Our expression data also …
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Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase
Regulation of intracellular pH is responsible for many cellular processes, such as metabolism, cell cycle progression, and apoptosis. Many chemotherapeutic agents work by inducing target cells to undergo apoptosis, a cell death process still poorly understood. Previous studies demonstrated that a …