Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"pERK"”.
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PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model
… revealed that PPARγ and active ERK (pERK) associated in Tg2576 hippocampal extracts in vivo, and that PPARγ agonism facilitated recruitment of PPARγ to pERK during memory consolidation. Furthermore, the amount of PPARγ recruited to pERK correlated with cognitive reserve in humans with …
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Does Firm Performance Impact Perk Usage? Evidence From Flights of Corporate Jets
This paper studies the connection between a firm's stock returns and financial performance as it relates to corporate jet usage. I identify changes in corporate equities and financial ratios to look for a resulting shift in detailed flight activity. For firms that are considered large based on …
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Biochemical Studies of the ER Resident Kinase PERK and Implications for Local Translational Control
… R (PKR)-like endoplasmic reticulum kinase (PERK) is able to couple ER stress to translational repression and transcriptional reprogramming through phosphorylation of eIF2α. This is achieved through the recruitment of eIF2α by a unique cytoplasmic loop in PERK’s kinase domain. PERK signalling …
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Biochemical and Biophysical Studies of the UPR Kinase PERK and its Interactors in Health and Disease
… of endoplasmic reticulum (ER) stress. The PERK-eIF2α branch of the UPR is activated by the accumulation of misfolded proteins in the ER lumen. PERK, upon activation through autophosphorylation, recruits its substrate eIF2α for phosphorylation, initiating a transcriptional and translational …
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Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
… kinase R–like endoplasmic reticulum kinase (PERK), encoded by EIF2AK3, is a crucial part of the integrated stress response (ISR) that regulates cellular adaptation to viral and inflammatory stimuli. Genetic variations in EIF2AK3 are linked to increased PERK activity and susceptibility to …
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Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
… in fibrogenic HSCs, propagated by ATF6α, PERK, and IRE1α, but how activated HSCs manage elevated UPR signaling while remaining viable is not well understood. This gap in knowledge limits therapeutic development to limit fibrosis progression. We identified Protein Kinase R-like ER Kinase …
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… reticulum (ER) and triggering ER stress and PERK signaling. Further, our lab discovered that heterozygous missense mutations in ACTA2, which encodes smooth muscle-specific α-actin (SM α-actin), predispose to premature coronary artery disease (CAD).</p> <p>In this dissertation, I conducted an …
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Mechanisms Regulating Amyloid Processing Enzymes in HIV-Associated Neurotoxicity
… explored PKR-like Endoplasmic Reticulum Kinase (PERK), one of three effectors of the unfolded protein response (UPR), as a potential regulator of APP secretases as it has an established role in modulating BACE1. Using PERK inhibitors, we found that the ADAM10 decrease with HIV/MDMs was not …
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Targeting protein kinases to manage or prevent Alzheimer’s disease
… kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta (Aβ) levels is also possible through development of protein kinase C-epsilon (PKC-ϵ) activators to recover α-secretase levels and decrease toxic Aβ levels, thereby restoring synaptogenesis and …
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Molecular Mechanisms of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
… found that the PRRSV-induced SGs are formed in a PERK-dependent manner. PERK is an important sensor of ER stress and activator of the unfolded protein response (UPR). Further investigation into the PERK signaling pathway revealed that PRRSV induces a significant amount of ER stress upon the cell …
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Analisi dell’espressione della fosfoERK quale strumento di indagine per la caratterizzazione della sensibilità alle sostanze d’abuso in linee di ratti geneticamente selezionati
… 1) that morphine significantly decreased Acb pERK expression, as determined by counting the number of pERK positive cells/area, in RLA, Sprague-Dawley and Wistar rats, 2) failed to either decrease or increase this measure in Acb of RHA rats and 3) significantly increased pERK expression in …
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The effect of exercise on spatial learning and hippocampal proteins in maternally separated adult rats
… signal-regulated protein kinase (pERK) in the hippocampus of non-separated-exercised rats. In the current study, the same MS technique and three-week voluntary exercise regimen were tested to determine their effect on spatial learning in young adult Sprague-Dawley (SD) rats. A …
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The role of organelle crosstalk in a Drosophila model of Parkinson’s disease
… is the protein kinase RNA (PKR)-like ER kinase (PERK). PERK activation leads to translational repression via phosphorylation of eukaryotic translation initiation factor-2 α (eIF2α) as well as activation of activating transcription factor 4 (ATF4). This triggers a transcriptional response, …
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PPARγ agonism attenuates cocaine seeking behavior via association with ERK MAPK
… abstinence prevented a decrease in a nuclear pERK/PPARγ protein complex after a cocaine cue reactivity test in the hippocampus and medial prefrontal cortex demonstrating a direct molecular mechanism for PPARy agonism action on pERK dependent plasticity. Our results demonstrate that PPARγ …
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Juvenile pilocytic astrocytomas: A search for prognostic markers
… fluorescence in-situ hybridisation and p16 and pERK by immunohistochemistry. Our findings were considered statistically significant if P < 0.05. Results: There were no specific light microscopic findings present in those cases associated with disease progression and recurrence. BRAF …
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Expression der CRFR-Gene in Antwort auf Stress und Lernen
… im Gyrus dentatus wird eine Aufregulation des pErk-1/2 und pElk-1 Gehalt 30 min nach Furchtkonditionierung aber nicht in entsprechenden Kontrollgruppen beobachtet. pErk-1/2 und pElk-1 sind in den hippokampalen Moosfaser assoziiert und in vitro phosphoryliert pErk-1/2 Elk-1. Umgekehrt erhöht …
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Rhabdomerorganisation und –morphogenese im Komplexauge von Drosophila
… in ihrer aktivierten (= phosphorylierten) Form (pERK bzw. pJNK) eine asymmetrische Verteilung an der Stielmembran aufweisen vergleichbar der Markierung mit anti-PY. Weiterhin wurde diese asymmetrische Verteilung von pERK und pJNK ebenso wie die von PY erst kurz vor Schlupf der Fliegen (bei ca. …
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Mechanism of Rare Variant In Acta2, P.Arg149Cys, Driving Diverse Vascular Disease
… SMCs assume a mSMC phenotype. Blocking the UPR Perk pathway abolishes SMC modulation <em>in vitro</em> and deletion of <em>Perk</em> prevents up to 80% of atherosclerotic plaque burden in hyperlipidemic mice. We sought to determine how <em>ACTA2 </em>p.Arg149Cys causes early-onset CAD.<strong> …
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Regulation of the unfolded protein response by GADD34 and CReP
… kinase RNA like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring ER-to-nucleus signal kinase 1 (IRE1). PERK activation leads to the phosphorylation of the α-subunit of the translation initiation factor eIF2α on Serine 51 in activating its …
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PRECLINICAL PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION OF NEW ANTICANCER AGENTS FOR BRAIN TUMOR CHEMOTHERAPY
… in vitro identified phosphorylated-ERK (pERK) as a PD marker. To assess time-dependent PK/PD characteristics, mice bearing intracerebral U87 glioma were administered ON013105 at 100 mg/kg intravenously and plasma, brain and brain tumor concentrations of ON013105 and its active form, …
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