Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"pDCs"”.
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Plasmacytoid Dendritic Cells Sense Skin Injury and Promote Wound Healing Through Type I Interferons
Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells, which selectively express intracellular Toll-like receptors (TLR)-7 and TLR-9 and have the capacity to produce large amounts of type I IFNs (IFN-a/b) in response to viruses or host derived nucleic acid containing …
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Interaktion des Frühsommer-Meningoenzephalitis- Virus mit antigenpräsentierenden Zellen
… plasmazytoiden dendritischen Zellen (mDCs und pDCs). Während die mDCs die potenteren APCs sind, können die pDCs in Antwort auf eine virale Infektion binnen kurzer Zeit große Mengen an Typ I Interferonen produzieren, die dazu beitragen durch Etablierung eines antiviralen Status die …
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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
… myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) play important roles in driving host responses to RSV infection. mDCs present antigens to help Th cells differentiate, and pDCs protect against viral infection through type I interferons (IFNs). Despite data demonstrating importance of mDCs …
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The Biology of Dendritic Cells in the Context of Autoimmunity
… Because plasmacytoid dendritic cells (pDCs) are the primary type I IFN producers, their role in SLE has long been suspected, with murine pDC depletion models successfully delaying the progression of murine lupus-like disease. However, the mechanism behind how exactly how pDCs contribute …
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Exploring Collaboration between Regional Planning and Public Health in Southwest Virginia
… between planning district commissions (PDCs) and health districts in the area. Using a case study approach, I collected data through in-depth, semi-structured interviews with the directors of four PDCs and four health districts of southwest Virginia. The results from this study reveal …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that stimulate the development of humoral …
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The Virginia Tech Phasor Data Concentrator Analysis & Testing System
… power systems, Phasor Data Concentrators (PDCs) play a crucial part in accurately relaying data from the point of measurement to the operators at the control center. The current Synchrophasor standard, IEEE C37.118-2005 covers adequately the steady state characterization of PMUs but does …
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Evaluation and Standardizing of Phasor Data Concentrators
… that PMU and PDC communication is seamless. PDCs are set up at multiple utilities and power authorities and also need to be able to communicate and send data to one another seamlessly to encompass analysis of large measurement systems. If these devices are not working similarly when …
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Assessing the Boundaries of Participatory Democracy within an Emancipatory Political Framework: The Case of Parish Development Committees in Jamaica
… of Jamaica's Parish Development Committees (PDCs). These groups offer an avenue for Jamaicans to inform government policy, and this analysis explored the extent to which supportive institutional, infrastructural and superstructural (referring to the society's culture and power configurations) …
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One-Carbon Bridge Stapling for use in Peptide-Drug Conjugates
… the synthesis of two peptide-drug conjugates (PDCs) using this methodology. 1.0 The Development of a One-Carbon Bridge Peptide Stapling Methodology Disulfide bonds are fundamental in many proteins and peptides; they are responsible for determining the tertiary and secondary structure …
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Historic and prehistoric volcanic activity on St Kitts and Nevis, West Indies: Controls on future hazard
… the nature of the pyroclastic density currents (PDCs) on St Kitts and Nevis. Pyroclastic density currents (PDCs) of pumice and ash flows, and surge deposits characterise the youngest products at both Mt Liamuiga and Nevis Peak, although subordinate lapilli fallout deposits also occur on St Kitts. …
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Treatment of Systemic Lupus Erythematosus by Nutrition and Dendritic Cell Targeting
… and adaptive immune systems. Plasmacytoid DCs (pDCs) as a candidate target have been demonstrated to be crucial for the initiation of lupus development by producing IFNα. However, we demonstrated that although pDCs produced a large amount of IFNα during disease initiation, those from late-stage …
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Characterization of crater morphometry on the Moon and Mercury from altimetry observations
… including 42 polar-deposit-hosting craters (PDCs) which host material that is bright to earth-based radar observations. A comparative analysis suggests that the radar-bright material forms a thin (< 20 m) layer emplaced preferentially in comparatively young craters, contradicting an earlier …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
… on the presence of plasmacytoid dendritic cells (pDCs), suggesting monocytes as the possible source of the interferon response. In the last study, we examined the responses of plasmacytoid dendritic cells (pDCs) to HIV and other stimuli in healthy and HIV-infected subjects. We observed induction …
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1, 2, and 3 Dimension Carbon/Silicon Carbon Nitride Ceramic Composites
Polymer-derived ceramics (PDCs) are exceptional ultra-high temperature and stable multifunctional class of materials that can be synthesized from a polymer precursor through thermal decomposition. The presented research focuses on 1-D nanofibers, 2-D films and 3-D bulk, carbon-rich silicon carbon …
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The Role and Regulation of Id2 In Dendritic Cells
… Prior work found <em>Id2</em> is induced in pDCs upon maturation, suggesting Id2 may be an important regulator of pDC function and that TLR agonist signaling directly regulates <em>Id2</em> gene expression. It also remains unknown whether TLR agonist-regulated Id2 is important in other DC …
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A GIS-Based Volcanic Hazard and Risk Assessment of Eruptions Sourced within Valles Caldera, New Mexico
… ash fallout, pyroclastic density currents (PDCs), and lava flows based on the Late Quaternary (~55 ka) eruptions from within Valles caldera. Simulated ash fall deposits originating from El Cajete crater are calibrated to isopach and lithic isopleth maps of the Lower and Upper El Cajete ash …
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Applications of PMUSimulator in PDC Testing
… to possess enough real PMUs to thoroughly test PDCs, thus a Real Time PMU Simulator is desired. It is possible to implement a UNIX based PMU simulator that can emulate the behavior of real PMUs, while also allowing the user to alter the Synchrophasor data to test the response of a PDC. GPS is …
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Targeting of specific developmental pathways to understand dendritic cell heterogeneity and function
… well understood. Plasmacytoid dendritic cells (PDCs) are a subset of dendritic cells that are specialized at the secretion of type I interferon. Through conditional targeting of E2-2, a transcription factor essential for the specification of the PDC lineage, we have demonstrated a vital role for …
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Perceptual depth cues in support of medical data visualisation
… it examines the use of perceptual depth cues (PDCs) and perceptual depth cue theory to create effective visualisations. Two visualisation systems are explored: one to display X-ray data and the other to display volumetric data. The systems are enhanced using stereoscopic and motion PDCs. The …
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